Gene description for Lama5
Gene name laminin, alpha 5
Gene symbol Lama5
Other names/aliases AA408760
Species Mus musculus
 Database cross references - Lama5
ExoCarta ExoCarta_16776
Entrez Gene 16776
UniProt Q61001  
 Lama5 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Lama5
Molecular Function
    receptor binding GO:0005102 IEA
    integrin binding GO:0005178 ISO
    protein binding GO:0005515 IPI
Biological Process
    organ morphogenesis GO:0009887 IMP
    regulation of cell migration GO:0030334 IEA
    hair follicle development GO:0001942 IMP
    cell adhesion GO:0007155 IEA
    regulation of cell proliferation GO:0042127 IMP
    regulation of embryonic development GO:0045995 IEA
    cilium assembly GO:0042384 IMP
    muscle organ development GO:0007517 IMP
    cell migration GO:0016477 ISO
    morphogenesis of a polarized epithelium GO:0001738 IMP
    establishment of protein localization to plasma membrane GO:0090002 IMP
    integrin-mediated signaling pathway GO:0007229 ISO
    lung development GO:0030324 IMP
    morphogenesis of embryonic epithelium GO:0016331 IMP
    regulation of cell adhesion GO:0030155 IEA
    neural crest cell migration GO:0001755 IMP
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    branching involved in salivary gland morphogenesis GO:0060445 IMP
    odontogenesis of dentin-containing tooth GO:0042475 IMP
    branching involved in ureteric bud morphogenesis GO:0001658 IMP
    branching morphogenesis of an epithelial tube GO:0048754 IMP
Subcellular Localization
    laminin-10 complex GO:0043259 ISO
    basement membrane GO:0005604 ISO
    proteinaceous extracellular matrix GO:0005578 IDA
    nucleus GO:0005634 ISO
    basal lamina GO:0005605 IDA
    extracellular exosome GO:0070062 ISO
    laminin-5 complex GO:0005610 ISO
    extracellular space GO:0005615 ISO
    extracellular region GO:0005576 IEA
    extracellular matrix GO:0031012 ISO
 Experiment description of studies that identified Lama5 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Lama5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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