Gene description for Ambra1
Gene name	autophagy/beclin 1 regulator 1
Gene symbol	Ambra1
Other names/aliases	2310079H06Rik A130023A14 AA474864 AV021921 D030051N19Rik mKIAA1736
Species	Mus musculus
Database cross references - Ambra1
ExoCarta	ExoCarta_228361
Vesiclepedia	VP_228361
Entrez Gene	228361
UniProt	A2AH22
Ambra1 identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Ambra1

Molecular Function     protein binding GO:0005515 IPI     protein phosphatase binding GO:0019903 IEA     protein phosphatase binding GO:0019903 ISO     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     GTPase binding GO:0051020 IEA     GTPase binding GO:0051020 ISO     protein phosphatase activator activity GO:0072542 ISS     ubiquitin-like ligase-substrate adaptor activity GO:1990756 IBA     ubiquitin-like ligase-substrate adaptor activity GO:1990756 ISO     ubiquitin-like ligase-substrate adaptor activity GO:1990756 ISS Biological Process     autophagosome assembly GO:0000045 IBA     autophagosome assembly GO:0000045 ISO     autophagosome assembly GO:0000045 ISS     protein polyubiquitination GO:0000209 ISO     protein polyubiquitination GO:0000209 ISS     mitophagy GO:0000423 IBA     mitophagy GO:0000423 IEA     mitophagy GO:0000423 ISO     regulation of transcription by RNA polymerase II GO:0006357 IDA     autophagy GO:0006914 IMP     negative regulation of cell population proliferation GO:0008285 IMP     cellular response to starvation GO:0009267 IEA     embryo development GO:0009790 IMP     positive regulation of autophagy GO:0010508 IDA     positive regulation of autophagy GO:0010508 ISO     negative regulation of cardiac muscle cell apoptotic process GO:0010667 IEA     negative regulation of cardiac muscle cell apoptotic process GO:0010667 ISO     neural tube development GO:0021915 IMP     cell differentiation GO:0030154 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO     negative regulation of neuron apoptotic process GO:0043524 IMP     positive regulation of regulatory T cell differentiation GO:0045591 IMP     positive regulation of regulatory T cell differentiation GO:0045591 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     response to mitochondrial depolarisation GO:0098780 IEA     response to mitochondrial depolarisation GO:0098780 ISO     positive regulation of mitophagy GO:1901526 ISO     positive regulation of mitophagy GO:1901526 ISS     positive regulation of free ubiquitin chain polymerization GO:1904544 ISO     positive regulation of free ubiquitin chain polymerization GO:1904544 ISS     regulation of G1/S transition of mitotic cell cycle GO:2000045 ISO     regulation of G1/S transition of mitotic cell cycle GO:2000045 ISS Subcellular Localization     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 ISO     mitochondrion GO:0005739 ISO     mitochondrion GO:0005739 ISO     autophagosome GO:0005776 IEA     endoplasmic reticulum GO:0005783 IEA     cytosol GO:0005829 IDA     cytosol GO:0005829 ISO     cytoskeleton GO:0005856 ISO     focal adhesion GO:0005925 IEA     axoneme GO:0005930 IDA     intracellular membrane-bounded organelle GO:0043231 IBA     phagocytic vesicle GO:0045335 IDA     Cul4-RING E3 ubiquitin ligase complex GO:0080008 IBA     Cul4-RING E3 ubiquitin ligase complex GO:0080008 ISO     Cul4-RING E3 ubiquitin ligase complex GO:0080008 ISS