Gene description for FAM83D
Gene name family with sequence similarity 83, member D
Gene symbol FAM83D
Other names/aliases C20orf129
CHICA
dJ616B8.3
Species Homo sapiens
 Database cross references - FAM83D
ExoCarta ExoCarta_81610
Vesiclepedia VP_81610
Entrez Gene 81610
HGNC 16122
UniProt Q9H4H8  
 FAM83D identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for FAM83D
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IDA
    kinesin binding GO:0019894 IPI
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IPI
Biological Process
    epithelial to mesenchymal transition GO:0001837 IDA
    signal transduction GO:0007165 IBA
    cell population proliferation GO:0008283 IDA
    cell migration GO:0016477 IDA
    regulation of TOR signaling GO:0032006 IBA
    regulation of TOR signaling GO:0032006 IDA
    regulation of protein catabolic process GO:0042176 IDA
    cell division GO:0051301 IEA
    metaphase chromosome alignment GO:0051310 IMP
    regulation of ERK1 and ERK2 cascade GO:0070372 IBA
    regulation of ERK1 and ERK2 cascade GO:0070372 IMP
    protein localization to mitotic spindle GO:1902480 IBA
    protein localization to mitotic spindle GO:1902480 IMP
    positive regulation of cell cycle G1/S phase transition GO:1902808 IBA
    positive regulation of cell cycle G1/S phase transition GO:1902808 IMP
Subcellular Localization
    cytoplasm GO:0005737 IC
    cytoplasm GO:0005737 IDA
    spindle GO:0005819 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    microtubule cytoskeleton GO:0015630 IDA
    intercellular bridge GO:0045171 IDA
    mitotic spindle GO:0072686 IDA
    mitotic spindle pole GO:0097431 IBA
    mitotic spindle pole GO:0097431 IDA
 Experiment description of studies that identified FAM83D in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for FAM83D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TTC30B  
Affinity Capture-MS Homo sapiens
2 KRT83  
Affinity Capture-MS Homo sapiens
3 LRRC48  
Affinity Capture-MS Homo sapiens
4 SLX1A  
Affinity Capture-MS Homo sapiens
5 MAP2K2 5605
Affinity Capture-MS Homo sapiens
6 TRAK2 66008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 AVIL  
Affinity Capture-MS Homo sapiens
8 CSNK1D 1453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GMNN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 S100P 6286
Affinity Capture-MS Homo sapiens
11 TP53 7157
Affinity Capture-MS Homo sapiens
12 FTL 2512
Affinity Capture-MS Homo sapiens
13 PSMC3 5702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TBC1D2 55357
Affinity Capture-MS Homo sapiens
15 GSK3B 2932
Two-hybrid Homo sapiens
16 KIF14 9928
Affinity Capture-MS Homo sapiens
17 BACH1 571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 NRSN1  
Affinity Capture-MS Homo sapiens
19 PRMT1 3276
Two-hybrid Homo sapiens
20 MAPK1 5594
Affinity Capture-MS Homo sapiens
21 NCAPH2  
Affinity Capture-MS Homo sapiens
22 GADD45A  
Two-hybrid Homo sapiens
23 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CRYAB 1410
Affinity Capture-MS Homo sapiens
25 CRYAA 1409
Affinity Capture-MS Homo sapiens
26 TUBB4B 10383
Affinity Capture-MS Homo sapiens
27 POLR1E  
Affinity Capture-MS Homo sapiens
28 DYNC1I1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 MAP4 4134
Affinity Capture-MS Homo sapiens
30 KIF20A 10112
Affinity Capture-MS Homo sapiens
31 NHLRC2 374354
Affinity Capture-MS Homo sapiens
32 CUL3 8452
Affinity Capture-MS Homo sapiens
33 KRT81  
Affinity Capture-MS Homo sapiens
34 PRELID2  
Affinity Capture-MS Homo sapiens
35 KLHL34  
Affinity Capture-MS Homo sapiens
36 DUSP16  
Affinity Capture-MS Homo sapiens
37 MKI67  
Affinity Capture-MS Homo sapiens
38 Bach1 12013
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
39 ZAR1L  
Affinity Capture-MS Homo sapiens
40 HMMR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 C6orf141  
Affinity Capture-MS Homo sapiens
42 KCNE3  
Affinity Capture-MS Homo sapiens
43 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CDC16 8881
Affinity Capture-MS Homo sapiens
45 TUBB 203068
Affinity Capture-MS Homo sapiens
46 Sidt2  
Affinity Capture-MS Mus musculus
47 DNAI2  
Affinity Capture-MS Homo sapiens
48 SOHLH1  
Affinity Capture-MS Homo sapiens
49 NPAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 SEC16A 9919
Affinity Capture-MS Homo sapiens
51 RFXANK  
Affinity Capture-MS Homo sapiens
52 FBXW7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 NMD3 51068
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 HDAC6 10013
Affinity Capture-MS Homo sapiens
55 CSNK1E 1454
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
56 Dynll1 56455
Affinity Capture-MS Mus musculus
57 AR 367
Affinity Capture-MS Homo sapiens
58 KRAS 3845
Affinity Capture-MS Homo sapiens
59 CCDC96  
Affinity Capture-MS Homo sapiens
60 DYNLL2 140735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CCDC40  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 RPA3 6119
Proximity Label-MS Homo sapiens
63 PRPS2 5634
Affinity Capture-MS Homo sapiens
64 ATG7 10533
Affinity Capture-MS Homo sapiens
65 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 PIPSL 266971
Affinity Capture-MS Homo sapiens
67 POTEB3 102724631
Affinity Capture-MS Homo sapiens
68 CSNK1A1L 122011
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM83D is involved
PathwayEvidenceSource
Signal Transduction TAS Reactome
Signaling by EGFR TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome





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