Gene description for TBC1D2
Gene name TBC1 domain family, member 2
Gene symbol TBC1D2
Other names/aliases PARIS-1
PARIS1
TBC1D2A
Species Homo sapiens
 Database cross references - TBC1D2
ExoCarta ExoCarta_55357
Entrez Gene 55357
HGNC 18026
MIM 609871
UniProt Q9BYX2  
 TBC1D2 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for TBC1D2
Molecular Function
    cadherin binding GO:0045296 IPI
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of cilium assembly GO:1902017 IMP
    positive regulation of GTPase activity GO:0043547 IDA
Subcellular Localization
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    cell junction GO:0030054 IDA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified TBC1D2 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBC1D2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TBC1D2 is involved
No pathways found





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