Gene description for CRYAA
Gene name crystallin, alpha A
Gene symbol CRYAA
Other names/aliases CRYA1
CTRCT9
HSPB4
Species Homo sapiens
 Database cross references - CRYAA
ExoCarta ExoCarta_1409
Entrez Gene 1409
HGNC 2388
MIM 123580
UniProt P02489  
 CRYAA identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CRYAA
Molecular Function
    structural constituent of eye lens GO:0005212 IEA
    metal ion binding GO:0046872 IEA
    unfolded protein binding GO:0051082 IPI
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
Biological Process
    response to stimulus GO:0050896 IEA
    protein refolding GO:0042026 ISS
    negative regulation of apoptotic process GO:0043066 IMP
    visual perception GO:0007601 IMP
    protein homooligomerization GO:0051260 IDA
    negative regulation of intracellular transport GO:0032387 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified CRYAA in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CRYAA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MIP  
Invitro Homo sapiens
2 HSPB1 3315
Invivo Homo sapiens
Invitro Homo sapiens
3 LALBA  
Invitro Homo sapiens
4 ALB 213
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CRYAA is involved
No pathways found





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