Gene description for CRYAA
Gene name crystallin, alpha A
Gene symbol CRYAA
Other names/aliases CRYA1
CTRCT9
HSPB4
Species Homo sapiens
 Database cross references - CRYAA
ExoCarta ExoCarta_1409
Vesiclepedia VP_1409
Entrez Gene 1409
HGNC 2388
MIM 123580
UniProt P02489  
 CRYAA identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CRYAA
Molecular Function
    structural molecule activity GO:0005198 IDA
    structural constituent of eye lens GO:0005212 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
    unfolded protein binding GO:0051082 IBA
    unfolded protein binding GO:0051082 IMP
    unfolded protein binding GO:0051082 IPI
Biological Process
    lens development in camera-type eye GO:0002088 IBA
    visual perception GO:0007601 IMP
    response to heat GO:0009408 IBA
    negative regulation of intracellular transport GO:0032387 IDA
    protein refolding GO:0042026 IBA
    protein refolding GO:0042026 ISS
    negative regulation of apoptotic process GO:0043066 IBA
    negative regulation of apoptotic process GO:0043066 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    protein stabilization GO:0050821 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified CRYAA in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CRYAA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMG20B  
Affinity Capture-MS Homo sapiens
2 CRYGD  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
3 ZMYM4  
Affinity Capture-MS Homo sapiens
4 LOC102724652 102724652
Two-hybrid Homo sapiens
5 NSF 4905
Affinity Capture-MS Homo sapiens
6 RCOR2 283248
Affinity Capture-MS Homo sapiens
7 NUF2  
Affinity Capture-MS Homo sapiens
8 ZDHHC16  
Affinity Capture-MS Homo sapiens
9 GTF3C3 9330
Affinity Capture-MS Homo sapiens
10 SDCBP 6386
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 VAMP3 9341
Affinity Capture-MS Homo sapiens
12 HSPB2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
13 STARD7 56910
Affinity Capture-MS Homo sapiens
14 MIP  
FRET Homo sapiens
15 BAX 581
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 CRYGC  
Reconstituted Complex Bos taurus
17 SAP130  
Affinity Capture-MS Homo sapiens
18 BAG3 9531
Affinity Capture-MS Homo sapiens
19 DCP1B  
Affinity Capture-MS Homo sapiens
20 CRYGC  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 ALMS1  
Affinity Capture-MS Homo sapiens
22 CRYBA1  
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
23 TRRAP 8295
Affinity Capture-MS Homo sapiens
24 CRYBB2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 LETM1 3954
Affinity Capture-MS Homo sapiens
26 EDC4 23644
Affinity Capture-MS Homo sapiens
27 CRYAB 1410
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
28 CRYAA 1409
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
29 IQGAP3 128239
Affinity Capture-MS Homo sapiens
30 SPG21 51324
Two-hybrid Homo sapiens
31 TRIM7  
Affinity Capture-MS Homo sapiens
32 ATF7IP 55729
Affinity Capture-MS Homo sapiens
33 SMG7  
Affinity Capture-MS Homo sapiens
34 GSE1 23199
Affinity Capture-MS Homo sapiens
35 TRIM33 51592
Affinity Capture-MS Homo sapiens
36 MED6  
Affinity Capture-MS Homo sapiens
37 NFRKB  
Affinity Capture-MS Homo sapiens
38 HSPB1 3315
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
39 PRELID1  
Affinity Capture-MS Homo sapiens
40 ADNP 23394
Affinity Capture-MS Homo sapiens
41 FAM83H 286077
Affinity Capture-MS Homo sapiens
42 SETDB1  
Affinity Capture-MS Homo sapiens
43 TRAPPC3 27095
Affinity Capture-MS Homo sapiens
44 DECR1 1666
Affinity Capture-MS Homo sapiens
45 SATB2  
Affinity Capture-MS Homo sapiens
46 RCOR1  
Affinity Capture-MS Homo sapiens
47 TRIM24  
Affinity Capture-MS Homo sapiens
48 UBB 7314
Affinity Capture-MS Homo sapiens
49 BRCA2 675
Affinity Capture-MS Homo sapiens
50 KDM1A 23028
Affinity Capture-MS Homo sapiens
51 ZMYM6  
Affinity Capture-MS Homo sapiens
52 C15orf39  
Affinity Capture-MS Homo sapiens
53 BCL2L1 598
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
54 CNOT8  
Affinity Capture-MS Homo sapiens
55 WDYHV1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
56 ARHGEF5  
Affinity Capture-MS Homo sapiens
57 EDC3 80153
Affinity Capture-MS Homo sapiens
58 CCDC85B  
Affinity Capture-MS Homo sapiens
59 GORASP2 26003
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
60 FAM83D 81610
Affinity Capture-MS Homo sapiens
61 MED17  
Affinity Capture-MS Homo sapiens
62 STX8 9482
Affinity Capture-MS Homo sapiens
63 NAPG 8774
Affinity Capture-MS Homo sapiens
64 CEP85  
Affinity Capture-MS Homo sapiens
65 NYNRIN  
Affinity Capture-MS Homo sapiens
66 RCOR3  
Affinity Capture-MS Homo sapiens
67 HMG20A  
Affinity Capture-MS Homo sapiens
68 ZNF318 24149
Affinity Capture-MS Homo sapiens
69 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
70 ZMYM2  
Affinity Capture-MS Homo sapiens
71 CC2D1A 54862
Affinity Capture-MS Homo sapiens
72 BCOR  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CRYAA is involved
No pathways found





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