Gene description for BRCA2
Gene name breast cancer 2, early onset
Gene symbol BRCA2
Other names/aliases BRCC2
BROVCA2
FACD
FAD
FAD1
FANCD
FANCD1
GLM3
PNCA2
XRCC11
Species Homo sapiens
 Database cross references - BRCA2
ExoCarta ExoCarta_675
Entrez Gene 675
HGNC 1101
MIM 600185
UniProt P51587  
 BRCA2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for BRCA2
Molecular Function
    single-stranded DNA binding GO:0003697 IDA
    H3 histone acetyltransferase activity GO:0010484 IDA
    protease binding GO:0002020 IPI
    protein binding GO:0005515 IPI
    H4 histone acetyltransferase activity GO:0010485 IDA
    histone acetyltransferase activity GO:0004402 IDA
    gamma-tubulin binding GO:0043015 IPI
Biological Process
    spermatogenesis GO:0007283 IEA
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 IEA
    chromosome organization GO:0051276 IBA
    brain development GO:0007420 IEA
    hemopoiesis GO:0030097 IEA
    cell aging GO:0007569 IEA
    response to gamma radiation GO:0010332 IEA
    female gonad development GO:0008585 IEA
    histone H4 acetylation GO:0043967 IDA
    oocyte maturation GO:0001556 IEA
    regulation of cytokinesis GO:0032465 IEA
    nucleotide-excision repair GO:0006289 IMP
    response to UV-C GO:0010225 IEA
    replication fork protection GO:0048478 IEA
    inner cell mass cell proliferation GO:0001833 IEA
    DNA repair GO:0006281 TAS
    double-strand break repair via homologous recombination GO:0000724 TAS
    double-strand break repair GO:0006302 TAS
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    centrosome duplication GO:0051298 IMP
    negative regulation of mammary gland epithelial cell proliferation GO:0033600 IDA
    cytokinesis GO:0000910 IDA
    positive regulation of mitotic cell cycle GO:0045931 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IEA
    response to X-ray GO:0010165 IEA
    male meiosis I GO:0007141 IEA
    histone H3 acetylation GO:0043966 IDA
Subcellular Localization
    secretory granule GO:0030141 IDA
    centrosome GO:0005813 IDA
    BRCA2-MAGE-D1 complex GO:0033593 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    protein complex GO:0043234 IDA
 Experiment description of studies that identified BRCA2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for BRCA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMG20B  
Invivo Homo sapiens
Invitro Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
2 ATR  
Protein-peptide Homo sapiens
3 FANCG  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 FANCD2  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
5 STAT5A 6776
Affinity Capture-Western Homo sapiens
6 RPA1 6117
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 BRCA1 672
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
8 SHFM1 7979
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
9 BUB1B  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
10 PCAF  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 PLK1 5347
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 BRE 9577
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
13 FANCE  
Affinity Capture-Western Homo sapiens
14 C11orf30  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
15 SMAD3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 ATM  
Reconstituted Complex Homo sapiens
17 BARD1 580
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
18 CXorf53  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
19 FLNA 2316
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
20 TP53  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
21 BCCIP 56647
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
22 SMAD2 4087
Affinity Capture-Western Homo sapiens
23 Rad51  
Two-hybrid Mus musculus
24 RAD51  
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
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