Gene description for MMP10
Gene name matrix metallopeptidase 10
Gene symbol MMP10
Other names/aliases SL-2
STMY2
Species Homo sapiens
 Database cross references - MMP10
ExoCarta ExoCarta_4319
Vesiclepedia VP_4319
Entrez Gene 4319
HGNC 7156
MIM 185260
UniProt P09238  
 MMP10 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MMP10
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 TAS
    serine-type endopeptidase activity GO:0004252 TAS
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 IEA
    extracellular matrix disassembly GO:0022617 TAS
    extracellular matrix organization GO:0030198 IBA
    collagen catabolic process GO:0030574 IBA
    collagen catabolic process GO:0030574 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular matrix GO:0031012 IEA
 Experiment description of studies that identified MMP10 in exosomes
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MMP10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 B4GALT1 2683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 BMP4 652
Affinity Capture-MS Homo sapiens
3 PCSK1N  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 HS3ST1  
Affinity Capture-MS Homo sapiens
5 LTBP1 4052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 NPTX1  
Affinity Capture-MS Homo sapiens
7 BRCA2 675
Affinity Capture-MS Homo sapiens
8 BCAN  
Biochemical Activity Homo sapiens
9 APOE 348
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TIMP1 7076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NMU  
Affinity Capture-MS Homo sapiens
12 ITIH2 3698
Affinity Capture-MS Homo sapiens
13 GAL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NUCB1 4924
Affinity Capture-MS Homo sapiens
15 EMILIN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 NPW  
Affinity Capture-MS Homo sapiens
17 MMP3 4314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MAN1A1 4121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TNFSF9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 TRAF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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