Gene description for MMP3
Gene name matrix metallopeptidase 3
Gene symbol MMP3
Other names/aliases CHDS6
MMP-3
SL-1
STMY
STMY1
STR1
Species Homo sapiens
 Database cross references - MMP3
ExoCarta ExoCarta_4314
Entrez Gene 4314
HGNC 7173
MIM 185250
UniProt P08254  
 MMP3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MMP3
Molecular Function
    endopeptidase activity GO:0004175 IDA
    zinc ion binding GO:0008270 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    metalloendopeptidase activity GO:0004222 IEA
Biological Process
    collagen catabolic process GO:0030574 TAS
    extracellular matrix organization GO:0030198 TAS
    positive regulation of oxidative stress-induced cell death GO:1903209 ISS
    negative regulation of hydrogen peroxide metabolic process GO:0010727 IDA
    cellular response to nitric oxide GO:0071732 TAS
    proteolysis GO:0006508 IDA
    positive regulation of protein oligomerization GO:0032461 IDA
    extracellular matrix disassembly GO:0022617 TAS
Subcellular Localization
    extracellular space GO:0005615 TAS
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified MMP3 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MMP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPOCK3  
Invivo Homo sapiens
2 TIMP1 7076
Co-crystal Structure Homo sapiens
3 TIMP3 7078
Invivo Homo sapiens
Invitro Homo sapiens
4 BCAN  
Biochemical Activity Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here