Gene description for BRE
Gene name brain and reproductive organ-expressed (TNFRSF1A modulator)
Gene symbol BRE
Other names/aliases BRCC4
BRCC45
Species Homo sapiens
 Database cross references - BRE
ExoCarta ExoCarta_9577
Entrez Gene 9577
HGNC 1106
MIM 610497
UniProt Q9NXR7  
 BRE identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for BRE
Molecular Function
    peroxisome targeting sequence binding GO:0000268 TAS
    tumor necrosis factor receptor binding GO:0005164 IDA
    protein binding GO:0005515 IPI
    polyubiquitin binding GO:0031593 IDA
Biological Process
    chromatin modification GO:0016568 IEA
    response to ionizing radiation GO:0010212 IMP
    G2 DNA damage checkpoint GO:0031572 IMP
    apoptotic process GO:0006915 IEA
    double-strand break repair GO:0006302 IMP
    positive regulation of DNA repair GO:0045739 IMP
    signal transduction GO:0007165 TAS
    cellular response to DNA damage stimulus GO:0006974 IEP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    BRCA1-A complex GO:0070531 IDA
    nuclear ubiquitin ligase complex GO:0000152 IDA
    nucleus GO:0005634 IDA
    BRISC complex GO:0070552 IDA
 Experiment description of studies that identified BRE in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BRE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BABAM1 29086
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 BRCA1 672
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
3 BRCA2 675
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
4 FAM175B 23172
Affinity Capture-MS Homo sapiens
5 BARD1 580
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
6 RAD51  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
7 CXorf53  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
8 TP53  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
9 UBE2D1  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which BRE is involved
No pathways found





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