Gene description for MMS19
Gene name MMS19 nucleotide excision repair homolog (S. cerevisiae)
Gene symbol MMS19
Other names/aliases MET18
MMS19L
hMMS19
Species Homo sapiens
 Database cross references - MMS19
ExoCarta ExoCarta_64210
Entrez Gene 64210
HGNC 13824
MIM 614777
UniProt Q96T76  
 MMS19 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for MMS19
Molecular Function
    receptor signaling complex scaffold activity GO:0030159 NAS
    estrogen receptor binding GO:0030331 IPI
    protein binding, bridging GO:0030674 NAS
    transcription coactivator activity GO:0003713 IMP
    protein binding GO:0005515 IPI
Biological Process
    response to hormone GO:0009725 NAS
    phosphorelay signal transduction system GO:0000160 NAS
    iron-sulfur cluster assembly GO:0016226 IMP
    chromosome segregation GO:0007059 IMP
    DNA metabolic process GO:0006259 IMP
    DNA repair GO:0006281 IMP
    cellular response to DNA damage stimulus GO:0006974 IMP
    transcription, DNA-templated GO:0006351 NAS
    small molecule metabolic process GO:0044281 TAS
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    nucleotide-excision repair GO:0006289 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    nucleus GO:0005634 TAS
    MMXD complex GO:0071817 IDA
    holo TFIIH complex GO:0005675 NAS
    CIA complex GO:0097361 IDA
    cytoplasm GO:0005737 IDA
    spindle GO:0005819 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified MMS19 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MMS19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PHB2 11331
Affinity Capture-MS Homo sapiens
2 ILK 3611
Affinity Capture-MS Homo sapiens
3 PTP4A3  
Affinity Capture-MS Homo sapiens
4 GIPC1 10755
Affinity Capture-MS Homo sapiens
5 MLF2 8079
Affinity Capture-MS Homo sapiens
6 PHLDA3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MMS19 is involved
PathwayEvidenceSource
Cytosolic iron-sulfur cluster assembly IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here