Gene description for RTEL1
Gene name	regulator of telomere elongation helicase 1
Gene symbol	RTEL1
Other names/aliases	C20orf41 DKCA4 DKCB5 NHL RTEL
Species	Homo sapiens
Database cross references - RTEL1
ExoCarta	ExoCarta_51750
Vesiclepedia	VP_51750
Entrez Gene	51750
HGNC	15888
MIM	608833
UniProt	Q9NZ71
RTEL1 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723
Urine	21595033
Urine	21595033
Urine	21595033

Gene ontology annotations for RTEL1

Molecular Function     DNA binding GO:0003677 IEA     DNA helicase activity GO:0003678 IBA     DNA helicase activity GO:0003678 IMP     DNA helicase activity GO:0003678 ISS     DNA helicase activity GO:0003678 TAS     DNA clamp loader activity GO:0003689 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IBA     ATP binding GO:0005524 IMP     four-way junction helicase activity GO:0009378 IEA     isomerase activity GO:0016853 IEA     ATP hydrolysis activity GO:0016887 IEA     double-stranded DNA helicase activity GO:0036121 IEA     metal ion binding GO:0046872 IEA     4 iron, 4 sulfur cluster binding GO:0051539 IEA     forked DNA-dependent helicase activity GO:0061749 IEA     cohesin loader activity GO:0061775 IEA     DNA polymerase binding GO:0070182 IBA     chromatin extrusion motor activity GO:0140584 IEA     ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA     ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA     single-stranded 3'-5' DNA helicase activity GO:1990518 IEA Biological Process     telomere maintenance GO:0000723 IMP     telomere maintenance GO:0000723 ISS     DNA strand displacement GO:0000732 ISS     DNA strand displacement GO:0000732 TAS     DNA repair GO:0006281 IEA     chromatin remodeling GO:0006338 IEA     regulation of double-strand break repair via homologous recombination GO:0010569 IBA     regulation of double-strand break repair via homologous recombination GO:0010569 IMP     replication fork processing GO:0031297 ISS     positive regulation of telomere maintenance GO:0032206 ISS     DNA duplex unwinding GO:0032508 IBA     DNA duplex unwinding GO:0032508 ISS     telomere maintenance in response to DNA damage GO:0043247 ISS     negative regulation of DNA recombination GO:0045910 IBA     negative regulation of DNA recombination GO:0045910 ISS     telomeric loop disassembly GO:0090657 IBA     telomeric loop disassembly GO:0090657 IMP     telomeric loop disassembly GO:0090657 ISS     chromatin looping GO:0140588 IEA     mitotic telomere maintenance via semi-conservative replication GO:1902990 ISS     positive regulation of telomere capping GO:1904355 IMP     positive regulation of telomere maintenance via telomere lengthening GO:1904358 IMP     negative regulation of t-circle formation GO:1904430 IBA     negative regulation of t-circle formation GO:1904430 IMP     negative regulation of t-circle formation GO:1904430 ISS     negative regulation of t-circle formation GO:1904430 TAS     negative regulation of telomere maintenance in response to DNA damage GO:1904506 ISS     positive regulation of telomeric loop disassembly GO:1904535 ISS Subcellular Localization     chromosome, telomeric region GO:0000781 ISS     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     nuclear speck GO:0016607 IDA     nuclear membrane GO:0031965 IDA