Gene description for VAV2
Gene name vav 2 guanine nucleotide exchange factor
Gene symbol VAV2
Other names/aliases VAV-2
Species Homo sapiens
 Database cross references - VAV2
ExoCarta ExoCarta_7410
Vesiclepedia VP_7410
Entrez Gene 7410
HGNC 12658
MIM 600428
UniProt P52735  
 VAV2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for VAV2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    protein binding GO:0005515 IPI
    epidermal growth factor receptor binding GO:0005154 IEA
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    cell migration GO:0016477 IEA
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    signal transduction GO:0007165 TAS
    regulation of gene expression GO:0010468 IMP
    lamellipodium assembly GO:0030032 IEA
    positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IEA
    regulation of blood coagulation GO:0030193 IMP
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    positive regulation of apoptotic process GO:0043065 TAS
    ephrin receptor signaling pathway GO:0048013 TAS
    platelet activation GO:0030168 TAS
    positive regulation of GTPase activity GO:0043547 IEA
    apoptotic signaling pathway GO:0097190 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    small GTPase mediated signal transduction GO:0007264 TAS
    blood coagulation GO:0007596 TAS
    angiogenesis GO:0001525 IEA
    axon guidance GO:0007411 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    innate immune response GO:0045087 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified VAV2 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VAV2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBL 867
Invivo Homo sapiens
2 CD44 960
Affinity Capture-Western Homo sapiens
3 SOCS1  
Affinity Capture-Western Homo sapiens
4 EGFR 1956
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
5 GRB2 2885
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
6 PDGFRB 5159
Affinity Capture-Western Homo sapiens
7 CD19 930
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml



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