Gene description for VAV2
Gene name vav 2 guanine nucleotide exchange factor
Gene symbol VAV2
Other names/aliases VAV-2
Species Homo sapiens
 Database cross references - VAV2
ExoCarta ExoCarta_7410
Vesiclepedia VP_7410
Entrez Gene 7410
HGNC 12658
MIM 600428
UniProt P52735  
 VAV2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for VAV2
Molecular Function
    phosphotyrosine residue binding GO:0001784 IPI
    guanyl-nucleotide exchange factor activity GO:0005085 EXP
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    epidermal growth factor receptor binding GO:0005154 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    angiogenesis GO:0001525 IEA
    immune response-regulating cell surface receptor signaling pathway GO:0002768 IBA
    signal transduction GO:0007165 TAS
    small GTPase-mediated signal transduction GO:0007264 IBA
    regulation of cell size GO:0008361 IGI
    regulation of cell size GO:0008361 IGI
    cell migration GO:0016477 IBA
    lamellipodium assembly GO:0030032 IEA
    platelet activation GO:0030168 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    regulation of GTPase activity GO:0043087 IGI
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IBA
    cellular response to xenobiotic stimulus GO:0071466 TAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified VAV2 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for VAV2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCNO  
Two-hybrid Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 Mbp 17196
Protein-peptide Mus musculus
4 TTN 7273
Two-hybrid Homo sapiens
5 PRRG4  
Reconstituted Complex Homo sapiens
6 RBBP6 5930
Two-hybrid Homo sapiens
7 Cct4 12464
Affinity Capture-MS Mus musculus
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 CBLB 868
Two-hybrid Homo sapiens
10 STK24 8428
Two-hybrid Homo sapiens
11 CHMP3 51652
Two-hybrid Homo sapiens
12 Tubg1 103733
Affinity Capture-MS Mus musculus
13 ERBB2 2064
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
14 CCT3 7203
Two-hybrid Homo sapiens
15 DNAJC21  
Two-hybrid Homo sapiens
16 BRDT  
Two-hybrid Homo sapiens
17 GRB2 2885
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
18 RAD23A 5886
Two-hybrid Homo sapiens
19 HSPH1 10808
Two-hybrid Homo sapiens
20 Espl1  
Affinity Capture-MS Mus musculus
21 UBE2H 7328
Affinity Capture-MS Homo sapiens
22 TPD52L2 7165
Co-fractionation Homo sapiens
23 SRPK2 6733
Two-hybrid Homo sapiens
24 ERBB4 2066
Reconstituted Complex Homo sapiens
25 PPM1B 5495
Two-hybrid Homo sapiens
26 POGZ 23126
Two-hybrid Homo sapiens
27 BOD1L1 259282
Two-hybrid Homo sapiens
28 THOP1 7064
Co-fractionation Homo sapiens
29 EIF4G3 8672
Two-hybrid Homo sapiens
30 Ccdc12  
Affinity Capture-MS Mus musculus
31 MARCH7  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
32 SOCS1  
Affinity Capture-Western Homo sapiens
33 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
34 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
35 CCT2 10576
Two-hybrid Homo sapiens
36 PNMA1 9240
Two-hybrid Homo sapiens
37 FNTA 2339
Two-hybrid Homo sapiens
38 PDGFRB 5159
Affinity Capture-Western Homo sapiens
39 ERBB3 2065
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
40 PRKAR2B 5577
Affinity Capture-MS Homo sapiens
41 A2M 2
Co-fractionation Homo sapiens
42 GAB1  
Reconstituted Complex Homo sapiens
43 MED21  
Two-hybrid Homo sapiens
44 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
45 SRRT 51593
Two-hybrid Homo sapiens
46 BIRC6 57448
Two-hybrid Homo sapiens
47 MRGBP  
Two-hybrid Homo sapiens
48 ARIH1 25820
Two-hybrid Homo sapiens
49 SF3A3 10946
Two-hybrid Homo sapiens
50 UBE4B 10277
Two-hybrid Homo sapiens
51 FYN 2534
Two-hybrid Homo sapiens
52 CEP170 9859
Two-hybrid Homo sapiens
53 CRCP  
Two-hybrid Homo sapiens
54 IPO4 79711
Two-hybrid Homo sapiens
55 NTRK1 4914
Affinity Capture-MS Homo sapiens
56 GAPVD1 26130
Two-hybrid Homo sapiens
57 FUCA1 2517
Two-hybrid Homo sapiens
58 SMAD3 4088
Affinity Capture-MS Homo sapiens
59 TARBP2  
Two-hybrid Homo sapiens
60 HNRNPF 3185
Two-hybrid Homo sapiens
61 CCDC14  
Proximity Label-MS Homo sapiens
62 MET 4233
Reconstituted Complex Homo sapiens
63 SERBP1 26135
Two-hybrid Homo sapiens
64 DCUN1D4  
Two-hybrid Homo sapiens
65 SNW1 22938
Two-hybrid Homo sapiens
66 SLC12A6 9990
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
67 CD44 960
Affinity Capture-Western Homo sapiens
68 AR 367
Reconstituted Complex Homo sapiens
69 SYK 6850
Two-hybrid Homo sapiens
70 PHF10  
Two-hybrid Homo sapiens
71 VCPIP1 80124
Two-hybrid Homo sapiens
72 CAV1 857
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
73 USP38 84640
Two-hybrid Homo sapiens
74 TOM1L1 10040
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
75 TCP11  
Two-hybrid Homo sapiens
76 CD19 930
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
77 CUL4A 8451
Affinity Capture-MS Homo sapiens
78 NCKAP5  
Two-hybrid Homo sapiens
79 BZW1 9689
Two-hybrid Homo sapiens
80 ST13 6767
Two-hybrid Homo sapiens
81 RTEL1 51750
Affinity Capture-MS Homo sapiens
82 SHC2 25759
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which VAV2 is involved
PathwayEvidenceSource
Axon guidance TAS Reactome
Azathioprine ADME TAS Reactome
CDC42 GTPase cycle TAS Reactome
Cell death signalling via NRAGE, NRIF and NADE TAS Reactome
DAP12 interactions TAS Reactome
DAP12 signaling TAS Reactome
Death Receptor Signaling TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Drug ADME TAS Reactome
EPH-ephrin mediated repulsion of cells TAS Reactome
EPH-Ephrin signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
FCERI mediated Ca+2 mobilization TAS Reactome
FCERI mediated MAPK activation TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
FCGR3A-mediated phagocytosis IEA Reactome
G alpha (12/13) signalling events TAS Reactome
GPCR downstream signalling TAS Reactome
GPVI-mediated activation cascade TAS Reactome
GPVI-mediated activation cascade IEA Reactome
Hemostasis TAS Reactome
Hemostasis IEA Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
L1CAM interactions TAS Reactome
Leishmania infection TAS Reactome
Leishmania infection IEA Reactome
Leishmania phagocytosis TAS Reactome
Leishmania phagocytosis IEA Reactome
Nervous system development TAS Reactome
NRAGE signals death through JNK TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
Parasite infection TAS Reactome
Parasite infection IEA Reactome
Parasitic Infection Pathways TAS Reactome
Parasitic Infection Pathways IEA Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet activation, signaling and aggregation IEA Reactome
RAC1 GTPase cycle TAS Reactome
RAC2 GTPase cycle TAS Reactome
RAC3 GTPase cycle TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
RHO GTPase cycle TAS Reactome
RHOA GTPase cycle TAS Reactome
RHOB GTPase cycle TAS Reactome
RHOC GTPase cycle TAS Reactome
RHOG GTPase cycle TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signal transduction by L1 TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by VEGF TAS Reactome
Signaling by VEGF IEA Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFR2 mediated vascular permeability TAS Reactome





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