Gene description for ERBB4
Gene name erb-b2 receptor tyrosine kinase 4
Gene symbol ERBB4
Other names/aliases ALS19
HER4
p180erbB4
Species Homo sapiens
 Database cross references - ERBB4
ExoCarta ExoCarta_2066
Entrez Gene 2066
HGNC 3432
MIM 600543
UniProt Q15303  
 ERBB4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ERBB4
Molecular Function
    epidermal growth factor receptor binding GO:0005154 IPI
    protein homodimerization activity GO:0042803 IPI
    transcription regulatory region DNA binding GO:0044212 IMP
    protein binding GO:0005515 IPI
    receptor signaling protein tyrosine kinase activity GO:0004716 IEA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA
    ATP binding GO:0005524 IEA
    protein tyrosine kinase activity GO:0004713 IDA
Biological Process
    protein autophosphorylation GO:0046777 IDA
    mammary gland alveolus development GO:0060749 ISS
    positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 IMP
    signal transduction GO:0007165 IDA
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    cell fate commitment GO:0045165 IEA
    embryonic pattern specification GO:0009880 ISS
    positive regulation of cell proliferation GO:0008284 IMP
    positive regulation of protein phosphorylation GO:0001934 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    heart development GO:0007507 ISS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    positive regulation of STAT protein import into nucleus GO:2000366 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    signal transduction by protein phosphorylation GO:0023014 IEA
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IDA
    innate immune response GO:0045087 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    nervous system development GO:0007399 ISS
    lactation GO:0007595 IMP
    mammary gland epithelial cell differentiation GO:0060644 ISS
    negative regulation of apoptotic process GO:0043066 IMP
    central nervous system morphogenesis GO:0021551 ISS
    mitochondrial fragmentation involved in apoptotic process GO:0043653 IMP
    cell proliferation GO:0008283 TAS
    regulation of cell migration GO:0030334 ISS
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    olfactory bulb interneuron differentiation GO:0021889 ISS
    negative regulation of cell proliferation GO:0008285 IMP
    positive regulation of cardiac muscle cell proliferation GO:0060045 ISS
    cardiac muscle tissue regeneration GO:0061026 ISS
    cell migration GO:0016477 IDA
    neural crest cell migration GO:0001755 ISS
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    receptor complex GO:0043235 IDA
    basolateral plasma membrane GO:0016323 IDA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
    extracellular region GO:0005576 TAS
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    mitochondrion GO:0005739 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified ERBB4 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ERBB4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NRG2 9542
Invivo Homo sapiens
Invitro Homo sapiens
2 DLG2 1740
Two-hybrid Homo sapiens
3 CRK 1398
Affinity Capture-MS Homo sapiens
4 MUC1 4582
Invivo Homo sapiens
5 EREG  
Invivo Homo sapiens
6 DLG1 1739
Invivo Homo sapiens
7 CD44 960
Affinity Capture-Western Homo sapiens
8 RNF41  
Reconstituted Complex Homo sapiens
9 PTPN11 5781
Affinity Capture-MS Homo sapiens
10 SNTB2 6645
Two-hybrid Homo sapiens
11 NCK1 4690
Affinity Capture-MS Homo sapiens
12 GRB2 2885
Affinity Capture-MS Homo sapiens
13 SHC1 6464
Affinity Capture-MS Homo sapiens
14 YAP1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
15 DLG4  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 ERBB2 2064
Affinity Capture-Western Homo sapiens
17 DLG3 1741
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 STAT5A 6776
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
19 PIK3R2  
Affinity Capture-MS Homo sapiens
20 BTC  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which ERBB4 is involved
No pathways found





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