Gene description for NRG2
Gene name neuregulin 2
Gene symbol NRG2
Other names/aliases DON1
HRG2
NTAK
Species Homo sapiens
 Database cross references - NRG2
ExoCarta ExoCarta_9542
Vesiclepedia VP_9542
Entrez Gene 9542
HGNC 7998
MIM 603818
UniProt O14511  
 NRG2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for NRG2
Molecular Function
    signaling receptor binding GO:0005102 IBA
    growth factor activity GO:0008083 IEA
Biological Process
    signal transduction GO:0007165 TAS
    nervous system development GO:0007399 IEA
    intracellular signal transduction GO:0035556 IBA
    ERBB4 signaling pathway GO:0038130 IBA
    animal organ development GO:0048513 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified NRG2 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for NRG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERBB4 2066
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
2 ERBB3 2065
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
3 TSC22D2 9819
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NRG2 is involved
PathwayEvidenceSource
Constitutive Signaling by Aberrant PI3K in Cancer TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of ERBB2 signaling TAS Reactome
Downregulation of ERBB2:ERBB3 signaling TAS Reactome
ERBB2 Activates PTK6 Signaling TAS Reactome
ERBB2 Regulates Cell Motility TAS Reactome
GRB2 events in ERBB2 signaling TAS Reactome
GRB7 events in ERBB2 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nuclear signaling by ERBB4 IEA Reactome
PI3K events in ERBB2 signaling TAS Reactome
PI3K events in ERBB4 signaling TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
RAF/MAP kinase cascade TAS Reactome
SHC1 events in ERBB2 signaling IEA Reactome
SHC1 events in ERBB2 signaling TAS Reactome
SHC1 events in ERBB4 signaling TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB2 IEA Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB2 TMD/JMD mutants TAS Reactome
Signaling by ERBB4 TAS Reactome
Signaling by ERBB4 IEA Reactome
Signaling by Non-Receptor Tyrosine Kinases TAS Reactome
Signaling by PTK6 TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome





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