Gene description for NRG2
Gene name neuregulin 2
Gene symbol NRG2
Other names/aliases DON1
Species Homo sapiens
 Database cross references - NRG2
ExoCarta ExoCarta_9542
Entrez Gene 9542
HGNC 7998
MIM 603818
UniProt O14511  
 NRG2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for NRG2
Molecular Function
    receptor binding GO:0005102 TAS
    growth factor activity GO:0008083 IEA
Biological Process
    innate immune response GO:0045087 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    embryo development GO:0009790 IEA
    intracellular signal transduction GO:0035556 IBA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    organ development GO:0048513 IBA
    signal transduction GO:0007165 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
    intracellular GO:0005622 TAS
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified NRG2 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for NRG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERBB4 2066
Invivo Homo sapiens
Invitro Homo sapiens
2 ERBB3 2065
Invivo Homo sapiens
Invitro Homo sapiens
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