Gene description for TSC22D2
Gene name TSC22 domain family, member 2
Gene symbol TSC22D2
Other names/aliases TILZ4a
TILZ4b
TILZ4c
Species Homo sapiens
 Database cross references - TSC22D2
ExoCarta ExoCarta_9819
Vesiclepedia VP_9819
Entrez Gene 9819
HGNC 29095
UniProt O75157  
 TSC22D2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TSC22D2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    response to osmotic stress GO:0006970 IEA
    negative regulation of cell cycle GO:0045786 IMP
 Experiment description of studies that identified TSC22D2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TSC22D2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REV1  
Two-hybrid Homo sapiens
2 PSMA8 143471
Two-hybrid Homo sapiens
3 TTN 7273
Two-hybrid Homo sapiens
4 SPEF2 79925
Two-hybrid Homo sapiens
5 PRMT3 10196
Two-hybrid Homo sapiens
6 HSPA5 3309
Cross-Linking-MS (XL-MS) Homo sapiens
7 FASN 2194
Positive Genetic Homo sapiens
8 SNX3 8724
Two-hybrid Homo sapiens
9 LRRC6  
Two-hybrid Homo sapiens
10 ARID2  
Two-hybrid Homo sapiens
11 WDR77 79084
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
12 MTIF2 4528
Two-hybrid Homo sapiens
13 TMA7 51372
Two-hybrid Homo sapiens
14 ENOPH1 58478
Two-hybrid Homo sapiens
15 EPCAM 4072
Two-hybrid Homo sapiens
16 ANAPC10  
Two-hybrid Homo sapiens
17 KEAP1 9817
Affinity Capture-Western Homo sapiens
18 STK39 27347
Two-hybrid Homo sapiens
19 MGARP  
Affinity Capture-MS Homo sapiens
20 ZNF143  
Two-hybrid Homo sapiens
21 NRG2 9542
Affinity Capture-MS Homo sapiens
22 SCEL 8796
Two-hybrid Homo sapiens
23 LOC254896  
Affinity Capture-MS Homo sapiens
24 MSH3 4437
Two-hybrid Homo sapiens
25 ANKRD36 375248
Two-hybrid Homo sapiens
26 ADAM19 8728
Affinity Capture-MS Homo sapiens
27 LOXHD1  
Two-hybrid Homo sapiens
28 ITGA2 3673
Two-hybrid Homo sapiens
29 NRBP1 29959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
30 MED13 9969
Two-hybrid Homo sapiens
31 WNK3  
Two-hybrid Homo sapiens
32 KIAA0586  
Two-hybrid Homo sapiens
33 FLNB 2317
Two-hybrid Homo sapiens
34 SEC31A 22872
Two-hybrid Homo sapiens
35 PSMA7 5688
Two-hybrid Homo sapiens
36 FAM117B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 DNM3 26052
Affinity Capture-MS Homo sapiens
38 TSC22D4 81628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
40 F8 2157
Two-hybrid Homo sapiens
41 NGRN  
Two-hybrid Homo sapiens
42 ATP1B1 481
Two-hybrid Homo sapiens
43 TCEB2 6923
Affinity Capture-MS Homo sapiens
44 CLIP1 6249
Two-hybrid Homo sapiens
45 RNF2  
Two-hybrid Homo sapiens
46 RBL1  
Two-hybrid Homo sapiens
47 SPANXN2  
Affinity Capture-MS Homo sapiens
48 ZNF251  
Two-hybrid Homo sapiens
49 LPL 4023
Two-hybrid Homo sapiens
50 SAP18 10284
Two-hybrid Homo sapiens
51 TSC22D3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CCDC144A  
Two-hybrid Homo sapiens
53 ZMYM2  
Two-hybrid Homo sapiens
54 MPDZ  
Two-hybrid Homo sapiens
55 OSBPL1A 114876
Two-hybrid Homo sapiens
56 GPBP1  
Two-hybrid Homo sapiens
57 UFM1 51569
Two-hybrid Homo sapiens
58 C1QL3  
Affinity Capture-MS Homo sapiens
59 CCDC141  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TSC22D2 is involved
No pathways found





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