Gene description for DNM3
Gene name dynamin 3
Gene symbol DNM3
Other names/aliases Dyna III
Species Homo sapiens
 Database cross references - DNM3
ExoCarta ExoCarta_26052
Entrez Gene 26052
HGNC 29125
MIM 611445
UniProt Q9UQ16  
 DNM3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for DNM3
Molecular Function
    GTPase activity GO:0003924 ISS
    GTP binding GO:0005525 IEA
    protein binding GO:0005515 IPI
Biological Process
    metabolic process GO:0008152 ISS
    synapse assembly GO:0007416 ISS
    endocytosis GO:0006897 ISS
    filopodium assembly GO:0046847 ISS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISS
    mitochondrion GO:0005739 IEA
    dendritic spine GO:0043197 ISS
    extracellular exosome GO:0070062 IDA
    postsynaptic density GO:0014069 ISS
    microtubule GO:0005874 IEA
 Experiment description of studies that identified DNM3 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for DNM3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HOMER1  
Invitro Homo sapiens
2 FER  
Co-fractionation Homo sapiens
View the network image/svg+xml



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