Gene description for FER
Gene name fer (fps/fes related) tyrosine kinase
Gene symbol FER
Other names/aliases PPP1R74
TYK3
p94-Fer
Species Homo sapiens
 Database cross references - FER
ExoCarta ExoCarta_2241
Vesiclepedia VP_2241
Entrez Gene 2241
HGNC 3655
MIM 176942
UniProt P16591  
 FER identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FER
Molecular Function
    protein binding GO:0005515 IPI
    protein phosphatase 1 binding GO:0008157 IEA
    Rab GTPase binding GO:0017137 IEA
    ATP binding GO:0005524 IEA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    actin binding GO:0003779 IEA
    gamma-catenin binding GO:0045295 IEA
    epidermal growth factor receptor binding GO:0005154 IDA
    protein tyrosine kinase activity GO:0004713 TAS
    cadherin binding GO:0045296 IEA
    lipid binding GO:0008289 IDA
    protein kinase binding GO:0019901 IEA
Biological Process
    platelet-derived growth factor receptor signaling pathway GO:0048008 TAS
    regulation of lamellipodium assembly GO:0010591 IDA
    innate immune response GO:0045087 IBA
    positive regulation of cell migration GO:0030335 IMP
    Kit signaling pathway GO:0038109 ISS
    cell adhesion GO:0007155 IBA
    positive regulation of cell proliferation GO:0008284 TAS
    negative regulation of mast cell activation involved in immune response GO:0033007 ISS
    diapedesis GO:0050904 ISS
    protein phosphorylation GO:0006468 TAS
    cell proliferation GO:0008283 IMP
    insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028 ISS
    positive regulation of actin filament polymerization GO:0030838 IMP
    intracellular signal transduction GO:0035556 TAS
    chemotaxis GO:0006935 IBA
    microtubule cytoskeleton organization GO:0000226 IMP
    cytokine-mediated signaling pathway GO:0019221 IMP
    interleukin-6-mediated signaling pathway GO:0070102 IMP
    protein autophosphorylation GO:0046777 IDA
    regulation of fibroblast migration GO:0010762 IEA
    response to platelet-derived growth factor GO:0036119 ISS
    response to lipopolysaccharide GO:0032496 ISS
    regulation of protein phosphorylation GO:0001932 ISS
    cell-cell adhesion mediated by cadherin GO:0044331 ISS
    peptidyl-tyrosine autophosphorylation GO:0038083 IBA
    cellular response to insulin stimulus GO:0032869 ISS
    cell migration GO:0016477 IBA
    substrate adhesion-dependent cell spreading GO:0034446 ISS
    cell differentiation GO:0030154 IBA
    cellular response to macrophage colony-stimulating factor stimulus GO:0036006 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    actin cytoskeleton reorganization GO:0031532 ISS
    Fc-epsilon receptor signaling pathway GO:0038095 ISS
    cellular response to reactive oxygen species GO:0034614 ISS
    extracellular matrix-cell signaling GO:0035426 ISS
    mitotic cell cycle GO:0000278 IMP
    tyrosine phosphorylation of Stat3 protein GO:0042503 IDA
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    regulation of mast cell degranulation GO:0043304 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA
    cytoplasm GO:0005737 IDA
    lamellipodium GO:0030027 IDA
    cell cortex GO:0005938 IEA
    cell junction GO:0030054 IDA
    actin cytoskeleton GO:0015629 IDA
    microtubule cytoskeleton GO:0015630 IDA
    nuclear chromatin GO:0000790 IDA
 Experiment description of studies that identified FER in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FER
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTNNB1 1499
Biochemical Activity Homo sapiens
2 DNM1 1759
Co-fractionation Homo sapiens
3 DNM2 1785
Co-fractionation Homo sapiens
4 FER 2241
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
5 CDH1 999
Reconstituted Complex Homo sapiens
6 CTTN 2017
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
7 EGFR 1956
Invivo Homo sapiens
8 DNM3 26052
Co-fractionation Homo sapiens
9 TMF1 7110
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FER is involved
PathwayEvidenceSource
Signaling by SCF-KIT TAS Reactome





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