Gene description for CDC37
Gene name cell division cycle 37
Gene symbol CDC37
Other names/aliases P50CDC37
Species Homo sapiens
 Database cross references - CDC37
ExoCarta ExoCarta_11140
Vesiclepedia VP_11140
Entrez Gene 11140
HGNC 1735
MIM 605065
UniProt Q16543  
 CDC37 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for CDC37
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase regulator activity GO:0019887 IEA
    kinase binding GO:0019900 IPI
    protein kinase binding GO:0019901 IEA
    heat shock protein binding GO:0031072 IBA
    heat shock protein binding GO:0031072 IPI
    unfolded protein binding GO:0051082 IBA
    protein-folding chaperone binding GO:0051087 IBA
    Hsp90 protein binding GO:0051879 IEA
    scaffold protein binding GO:0097110 IPI
Biological Process
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 TAS
    protein folding GO:0006457 IBA
    protein targeting GO:0006605 TAS
    post-transcriptional regulation of gene expression GO:0010608 IEA
    protein stabilization GO:0050821 IBA
    regulation of type II interferon-mediated signaling pathway GO:0060334 IMP
    regulation of type I interferon-mediated signaling pathway GO:0060338 IMP
    positive regulation of type 2 mitophagy GO:1905091 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 HDA
    protein folding chaperone complex GO:0101031 IDA
    HSP90-CDC37 chaperone complex GO:1990565 IDA
 Experiment description of studies that identified CDC37 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
8
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
9
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
13
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
14
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
24
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
35
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
38
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
40
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
41
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
42
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDC37
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HDAC4  
Affinity Capture-MS Homo sapiens
2 WDR6 11180
Affinity Capture-MS Homo sapiens
3 MYLK4  
Affinity Capture-MS Homo sapiens
4 PRPF8 10594
Proximity Label-MS Homo sapiens
5 PKM 5315
Affinity Capture-MS Homo sapiens
6 DDX17 10521
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 EIF2AK1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
8 GAK 2580
Affinity Capture-MS Homo sapiens
9 APOE 348
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
10 AKT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
12 LOXL4 84171
Two-hybrid Homo sapiens
13 STK32A  
Two-hybrid Homo sapiens
14 TNIP1 10318
Two-hybrid Homo sapiens
15 FGFR3 2261
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
16 APEX1 328
Affinity Capture-RNA Homo sapiens
17 RIPK3 11035
Affinity Capture-MS Homo sapiens
18 FBXW4 6468
Two-hybrid Homo sapiens
19 ULK3 25989
Affinity Capture-MS Homo sapiens
20 STX1A 6804
Two-hybrid Homo sapiens
21 NRIP3  
Two-hybrid Homo sapiens
22 SMYD3 64754
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
23 CCDC138  
Two-hybrid Homo sapiens
24 SRC 6714
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
25 DNAJB1 3337
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
26 CHORDC1 26973
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
27 Rpl35 66489
Affinity Capture-MS Mus musculus
28 RSG1  
Affinity Capture-MS Homo sapiens
29 PPP6R3 55291
Co-fractionation Homo sapiens
30 FKBPL  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
31 EEF1A1 1915
Affinity Capture-MS Homo sapiens
32 RAD23A 5886
Two-hybrid Homo sapiens
33 ACTG1 71
Two-hybrid Homo sapiens
34 UNC45A 55898
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
35 RABGEF1 27342
Two-hybrid Homo sapiens
36 AURKA 6790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 HSP90AB4P 664618
Affinity Capture-MS Homo sapiens
38 RHOBTB2  
Affinity Capture-MS Homo sapiens
39 IFIT5 24138
Two-hybrid Homo sapiens
40 CDKN2B 1030
Affinity Capture-MS Homo sapiens
41 PSME1 5720
Two-hybrid Homo sapiens
42 Vav2  
Affinity Capture-MS Mus musculus
43 ESRRB  
Affinity Capture-MS Homo sapiens
44 FYN 2534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 MAP4K2  
Affinity Capture-MS Homo sapiens
46 OGT 8473
Reconstituted Complex Homo sapiens
47 YWHAQ 10971
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
48 Coro1c 23790
Affinity Capture-MS Mus musculus
49 PRKAR1B  
Two-hybrid Homo sapiens
50 STK32C  
Affinity Capture-MS Homo sapiens
51 SLC25A5 292
Affinity Capture-MS Homo sapiens
52 MAP2K7 5609
Affinity Capture-MS Homo sapiens
53 PHLPP1  
Proximity Label-MS Homo sapiens
54 HSPA5 3309
Affinity Capture-MS Homo sapiens
55 AHCYL1 10768
Co-fractionation Homo sapiens
56 NT5C1A  
Two-hybrid Homo sapiens
57 LMNB1 4001
Co-fractionation Homo sapiens
58 PRKCZ 5590
Affinity Capture-MS Homo sapiens
59 CUL3 8452
Affinity Capture-MS Homo sapiens
60 PRR20D  
Two-hybrid Homo sapiens
61 MAP2K5  
Affinity Capture-MS Homo sapiens
62 FKBP8 23770
Affinity Capture-MS Homo sapiens
63 TARS2 80222
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
64 PPHLN1  
Two-hybrid Homo sapiens
65 PRR20B  
Two-hybrid Homo sapiens
66 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
67 LUC7L2 51631
Two-hybrid Homo sapiens
68 PCBP1 5093
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 MID1 4281
Two-hybrid Homo sapiens
70 RPA3 6119
Proximity Label-MS Homo sapiens
71 PSKH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 HSPA1A 3303
Affinity Capture-MS Homo sapiens
73 HSPA4 3308
Co-fractionation Homo sapiens
74 CYP2C9  
Two-hybrid Homo sapiens
75 PDZK1 5174
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
76 AKT1 207
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
77 CAMK2G 818
Two-hybrid Homo sapiens
78 SNX5 27131
Two-hybrid Homo sapiens
79 STUB1 10273
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
80 CT45A1  
Two-hybrid Homo sapiens
81 BRAF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 GRK5 2869
Affinity Capture-MS Homo sapiens
83 ZNF235  
Two-hybrid Homo sapiens
84 DEAF1 10522
Two-hybrid Homo sapiens
85 CDC37 11140
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
86 SKP1 6500
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
87 CDK15  
Affinity Capture-MS Homo sapiens
88 JRK  
Two-hybrid Homo sapiens
89 HSP90AA1 3320
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
90 STK38L 23012
Affinity Capture-MS Homo sapiens
91 SGK2  
Affinity Capture-MS Homo sapiens
92 TBK1 29110
Affinity Capture-MS Homo sapiens
93 TCF4  
Two-hybrid Homo sapiens
94 ZNF205 7755
Two-hybrid Homo sapiens
95 CDK4 1019
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 DDR1 780
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 CRYM 1428
Two-hybrid Homo sapiens
98 EPHA2 1969
Affinity Capture-MS Homo sapiens
99 PTGES3 10728
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
100 CUL7 9820
Affinity Capture-MS Homo sapiens
101 SNX29  
Affinity Capture-MS Homo sapiens
102 RPS6KA6 27330
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
103 IL1B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
104 CDCA5  
Affinity Capture-MS Homo sapiens
105 HSP90AB2P 391634
Affinity Capture-MS Homo sapiens
106 PRKAA1 5562
Affinity Capture-MS Homo sapiens
107 LCK 3932
Proximity Label-MS Homo sapiens
108 RPA2 6118
Proximity Label-MS Homo sapiens
109 ENOX2  
Two-hybrid Homo sapiens
110 ZNF667  
Two-hybrid Homo sapiens
111 GFAP 2670
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
112 HSP90AB1 3326
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 SAFB 6294
Two-hybrid Homo sapiens
114 ELAVL3  
Two-hybrid Homo sapiens
115 ZNF266  
Two-hybrid Homo sapiens
116 INSRR 3645
Affinity Capture-MS Homo sapiens
117 CDK11B 984
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 ACTR1A 10121
Proximity Label-MS Homo sapiens
119 FER 2241
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 PRDX2 7001
Two-hybrid Homo sapiens
121 DNAJC7 7266
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
122 LIMK1 3984
Affinity Capture-MS Homo sapiens
123 RPS6KA2  
Affinity Capture-MS Homo sapiens
124 FTSJ1 24140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 USP7 7874
Co-fractionation Homo sapiens
126 FGFR1 2260
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
127 GCA 25801
Affinity Capture-MS Homo sapiens
128 LMAN1 3998
Proximity Label-MS Homo sapiens
129 VRK3 51231
Affinity Capture-MS Homo sapiens
130 KCTD9  
Two-hybrid Homo sapiens
131 PPP5C 5536
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
132 TTC4  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
133 CEP55 55165
Two-hybrid Homo sapiens
134 RNF32  
Two-hybrid Homo sapiens
135 RPL4 6124
Co-fractionation Homo sapiens
136 CDK5 1020
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
137 PSMD14 10213
Co-fractionation Homo sapiens
138 TUBA1C 84790
Affinity Capture-MS Homo sapiens
139 OGFR 11054
Co-fractionation Homo sapiens
140 BTBD3  
Two-hybrid Homo sapiens
141 BEND7 222389
Two-hybrid Homo sapiens
142 PATL1 219988
Co-fractionation Homo sapiens
143 TTC9C 283237
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
144 Ksr1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
145 PRKCE 5581
Affinity Capture-MS Homo sapiens
146 CGGBP1 8545
Two-hybrid Homo sapiens
147 TUBB 203068
Affinity Capture-MS Homo sapiens
148 TRIO 7204
Affinity Capture-MS Homo sapiens
149 RPS2 6187
Affinity Capture-MS Homo sapiens
150 EIF6 3692
Proximity Label-MS Homo sapiens
151 MGME1  
Affinity Capture-MS Homo sapiens
152 IKZF3  
Two-hybrid Homo sapiens
153 MRPL9 65005
Two-hybrid Homo sapiens
154 SPTBN4 57731
Two-hybrid Homo sapiens
155 EGFR 1956
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
156 SYCE2  
Two-hybrid Homo sapiens
157 PTK2 5747
Proximity Label-MS Homo sapiens
158 HSP90AA5P 730211
Affinity Capture-MS Homo sapiens
159 CKS1B  
Reconstituted Complex Homo sapiens
160 RIPK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 Stk11  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
162 RPS27 6232
Affinity Capture-MS Homo sapiens
163 CDC25C  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 TPM1 7168
Co-fractionation Homo sapiens
165 MYC  
Affinity Capture-MS Homo sapiens
166 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
167 PRPF4 9128
Affinity Capture-MS Homo sapiens
168 EEF1A2 1917
Affinity Capture-MS Homo sapiens
169 SLC12A6 9990
Affinity Capture-MS Homo sapiens
170 STAMBPL1  
Two-hybrid Homo sapiens
171 CDK10  
Affinity Capture-MS Homo sapiens
172 RAE1 8480
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 CKS2  
Reconstituted Complex Homo sapiens
174 MAP2K2 5605
Affinity Capture-MS Homo sapiens
175 IRAK2  
Affinity Capture-MS Homo sapiens
176 TERF2  
Affinity Capture-MS Homo sapiens
177 TRAF2 7186
Two-hybrid Homo sapiens
178 PARP1 142
Proximity Label-MS Homo sapiens
179 BHLHB9 80823
Two-hybrid Homo sapiens
180 NEK6 10783
Affinity Capture-MS Homo sapiens
181 ZBTB8A  
Two-hybrid Homo sapiens
182 CTAG1B  
Two-hybrid Homo sapiens
183 PRKCI 5584
Affinity Capture-MS Homo sapiens
184 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 ZBTB26  
Two-hybrid Homo sapiens
186 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
187 ATG101  
Affinity Capture-MS Homo sapiens
188 FKBP4 2288
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
189 CDK6 1021
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
190 PRKACA 5566
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 PDE9A  
Two-hybrid Homo sapiens
192 CDK1 983
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
193 PRAM1  
Two-hybrid Homo sapiens
194 ESR1  
Affinity Capture-MS Homo sapiens
195 EEF1A1P5 158078
Affinity Capture-MS Homo sapiens
196 AMOTL2 51421
Two-hybrid Homo sapiens
197 KRAS 3845
Negative Genetic Homo sapiens
198 MIPOL1  
Two-hybrid Homo sapiens
199 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
200 PTRF 284119
Two-hybrid Homo sapiens
201 IKBKB 3551
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 PRMT1 3276
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
203 CC2D1A 54862
Two-hybrid Homo sapiens
204 KRT76 51350
Two-hybrid Homo sapiens
205 FLCN 201163
Affinity Capture-Western Homo sapiens
206 CDKN2C  
Affinity Capture-MS Homo sapiens
207 CHGA  
Two-hybrid Homo sapiens
208 RIT1 6016
Negative Genetic Homo sapiens
209 ANKK1  
Affinity Capture-MS Homo sapiens
210 YWHAE 7531
Affinity Capture-MS Homo sapiens
211 SPERT  
Two-hybrid Homo sapiens
212 FAM9B  
Two-hybrid Homo sapiens
213 PRPH 5630
Two-hybrid Homo sapiens
214 MDFI  
Two-hybrid Homo sapiens
215 RPS6KA4 8986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
216 GAS8  
Two-hybrid Homo sapiens
217 SSB 6741
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
218 SYNE2 23224
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
219 STK36  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
220 RPS6KB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
221 TRIM54  
Two-hybrid Homo sapiens
222 AMHR2  
Affinity Capture-MS Homo sapiens
223 SYCP3  
Two-hybrid Homo sapiens
224 CAPZB 832
Affinity Capture-MS Homo sapiens
225 TRIM28 10155
Affinity Capture-MS Homo sapiens
226 EIF3B 8662
Affinity Capture-MS Homo sapiens
227 MFN2 9927
Proximity Label-MS Homo sapiens
228 MAP3K3 4215
Affinity Capture-MS Homo sapiens
229 IKBKE 9641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
230 CYLD  
Affinity Capture-MS Homo sapiens
231 BTBD10 84280
Two-hybrid Homo sapiens
232 PRR20C  
Two-hybrid Homo sapiens
233 NECAB1  
Two-hybrid Homo sapiens
234 HSPA8 3312
Affinity Capture-MS Homo sapiens
235 GOLGA6L9  
Two-hybrid Homo sapiens
236 PXMP2  
Proximity Label-MS Homo sapiens
237 EIF2AK2 5610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
238 DLD 1738
Affinity Capture-MS Homo sapiens
239 SAMM50 25813
Proximity Label-MS Homo sapiens
240 IRAK1  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
241 FKBP6  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
242 PARK2  
Affinity Capture-MS Homo sapiens
243 IGF1R 3480
Affinity Capture-MS Homo sapiens
244 COPE 11316
Affinity Capture-MS Homo sapiens
245 GOLGA2 2801
Two-hybrid Homo sapiens
246 POU6F2  
Two-hybrid Homo sapiens
247 MAPT  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
248 TUBA1B 10376
Affinity Capture-MS Homo sapiens
249 DIRAS3  
Proximity Label-MS Homo sapiens
250 NTRK1 4914
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
251 PLCE1 51196
Affinity Capture-MS Homo sapiens
252 ZNF837  
Two-hybrid Homo sapiens
253 CCDC152  
Two-hybrid Homo sapiens
254 U2AF2 11338
Affinity Capture-MS Homo sapiens
255 ZNF655  
Two-hybrid Homo sapiens
256 DHFRL1  
Proximity Label-MS Homo sapiens
257 DNM1L 10059
Affinity Capture-MS Homo sapiens
258 ZBED1  
Two-hybrid Homo sapiens
259 GSDMD 79792
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
260 ZAK 51776
Affinity Capture-MS Homo sapiens
261 KATNBL1  
Two-hybrid Homo sapiens
262 PPM1M  
Affinity Capture-MS Homo sapiens
263 ARHGAP10 79658
Affinity Capture-MS Homo sapiens
264 MASP1 5648
Affinity Capture-MS Homo sapiens
265 PPID 5481
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
266 LMNB2 84823
Two-hybrid Homo sapiens
267 MZT2B 80097
Two-hybrid Homo sapiens
268 HSP90AB3P 3327
Affinity Capture-MS Homo sapiens
269 FBXO6 26270
Affinity Capture-MS Homo sapiens
270 MAP3K7  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
271 CDKL2  
Affinity Capture-MS Homo sapiens
272 THAP1  
Two-hybrid Homo sapiens
273 LRRK1 79705
Affinity Capture-MS Homo sapiens
274 SSNA1 8636
Two-hybrid Homo sapiens
275 MTOR 2475
Two-hybrid Homo sapiens
276 RAF1 5894
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
277 SGK1  
Affinity Capture-MS Homo sapiens
278 STK4 6789
Affinity Capture-MS Homo sapiens
279 MSN 4478
Co-fractionation Homo sapiens
280 ARAF 369
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
281 CHUK 1147
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
282 AKAP1 8165
Proximity Label-MS Homo sapiens
283 REEP6  
Two-hybrid Homo sapiens
284 IMMT 10989
Two-hybrid Homo sapiens
285 AHSA1 10598
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
286 EIF2S1 1965
Reconstituted Complex Homo sapiens
287 RASSF3 283349
Affinity Capture-MS Homo sapiens
288 MAP2K6 5608
Affinity Capture-MS Homo sapiens
289 SLC25A6 293
Affinity Capture-MS Homo sapiens
290 LONP1 9361
Two-hybrid Homo sapiens
291 BLZF1  
Two-hybrid Homo sapiens
292 CCHCR1  
Two-hybrid Homo sapiens
293 IKBKG 8517
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
294 ZNF276 92822
Two-hybrid Homo sapiens
295 HNRNPM 4670
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
296 FNIP2  
Affinity Capture-Western Homo sapiens
297 PDZD8 118987
Affinity Capture-MS Homo sapiens
298 GRAMD3  
Two-hybrid Homo sapiens
299 CDK13 8621
Affinity Capture-MS Homo sapiens
300 PRR20E  
Two-hybrid Homo sapiens
301 PDIK1L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
302 LRRK2 120892
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
303 TCF20  
Affinity Capture-MS Homo sapiens
304 STK11 6794
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
305 RPS27L 51065
Affinity Capture-MS Homo sapiens
306 SERBP1 26135
Affinity Capture-MS Homo sapiens
307 AR 367
Reconstituted Complex Homo sapiens
308 SGK3 23678
Affinity Capture-MS Homo sapiens
309 CDK11A 728642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
310 CDKN2A 1029
Affinity Capture-MS Homo sapiens
311 UBE2H 7328
Affinity Capture-MS Homo sapiens
312 AURKC  
Affinity Capture-MS Homo sapiens
313 PRIM2 5558
Co-fractionation Homo sapiens
314 ACTR2 10097
Proximity Label-MS Homo sapiens
315 ABL2  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
316 NECAB2  
Two-hybrid Homo sapiens
317 CPOX 1371
Co-fractionation Homo sapiens
318 KIFC3 3801
Two-hybrid Homo sapiens
319 CCDC91 55297
Two-hybrid Homo sapiens
320 TSSK6 83983
Affinity Capture-MS Homo sapiens
321 CARD9 64170
Two-hybrid Homo sapiens
322 NFYC 4802
Proximity Label-MS Homo sapiens
323 PAICS 10606
Two-hybrid Homo sapiens
324 DISC1 27185
Two-hybrid Homo sapiens
325 TAB1 10454
Affinity Capture-MS Homo sapiens
326 APP 351
Two-hybrid Homo sapiens
327 RPS6KA3 6197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
328 TOP2A 7153
Affinity Capture-MS Homo sapiens
329 CEP70  
Two-hybrid Homo sapiens
330 TGFB1 7040
Affinity Capture-MS Homo sapiens
331 YES1 7525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
332 NCOA5  
Two-hybrid Homo sapiens
333 AK2 204
Affinity Capture-MS Homo sapiens
334 ACVR2B  
Affinity Capture-MS Homo sapiens
335 MAP3K6  
Affinity Capture-MS Homo sapiens
336 IFIT3 3437
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
337 ERBB2 2064
Affinity Capture-MS Homo sapiens
338 ADSS 159
Affinity Capture-MS Homo sapiens
339 KCTD13 253980
Two-hybrid Homo sapiens
340 LAMTOR1 55004
Proximity Label-MS Homo sapiens
341 PRR20A  
Two-hybrid Homo sapiens
342 C19orf44  
Two-hybrid Homo sapiens
343 EMD 2010
Affinity Capture-MS Homo sapiens
344 HCK 3055
Affinity Capture-Western Homo sapiens
345 ERBB3 2065
Affinity Capture-MS Homo sapiens
346 HSP90B1 7184
Co-fractionation Homo sapiens
347 A2M 2
Two-hybrid Homo sapiens
348 GCH1  
Two-hybrid Homo sapiens
349 VCP 7415
Affinity Capture-MS Homo sapiens
350 DDX5 1655
Affinity Capture-MS Homo sapiens
351 KRT75 9119
Two-hybrid Homo sapiens
352 CHEK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
353 PNMA2  
Two-hybrid Homo sapiens
354 DCTN1 1639
Two-hybrid Homo sapiens
355 ULK1  
Affinity Capture-MS Homo sapiens
356 AIP 9049
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
357 ITK 3702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
358 BTK 695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
359 CDK9 1025
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
360 DNAJB5  
Proximity Label-MS Homo sapiens
361 RPS15A 6210
Two-hybrid Homo sapiens
362 CAMKK2 10645
Affinity Capture-MS Homo sapiens
363 RPS6KA1 6195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
364 CTAG1A  
Two-hybrid Homo sapiens
365 UBE2I 7329
Biochemical Activity Homo sapiens
366 FNIP1  
Affinity Capture-Western Homo sapiens
367 TOMM34 10953
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
368 PSEN1 5663
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
369 CDK7 1022
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
370 PXN 5829
Proximity Label-MS Homo sapiens
371 CLK3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
372 PANX1 24145
Affinity Capture-MS Homo sapiens
373 NOS3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
374 CTNNB1 1499
Affinity Capture-MS Homo sapiens
375 GCDH 2639
Two-hybrid Homo sapiens
376 CDKL1  
Affinity Capture-MS Homo sapiens
377 SRRM4  
Two-hybrid Homo sapiens
378 CTTN 2017
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
379 MAP3K1 4214
Affinity Capture-MS Homo sapiens
380 TRAF3 7187
Two-hybrid Homo sapiens
381 FBXL12 54850
Two-hybrid Homo sapiens
382 NXF1 10482
Affinity Capture-RNA Homo sapiens
383 AURKB 9212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
384 SLC35B2 347734
Affinity Capture-MS Homo sapiens
385 FKBP5 2289
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
386 STK35  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
387 USP19 10869
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
388 RPAP3 79657
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
389 CUTC  
Two-hybrid Homo sapiens
390 USHBP1  
Two-hybrid Homo sapiens
391 CDKN2D  
Affinity Capture-MS Homo sapiens
392 FATE1  
Two-hybrid Homo sapiens
393 MGEA5 10724
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
394 FARP1 10160
Affinity Capture-MS Homo sapiens
395 KLHL2 11275
Two-hybrid Homo sapiens
396 TXLNA 200081
Co-fractionation Homo sapiens
397 TNK2 10188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
398 GSK3B 2932
Affinity Capture-MS Homo sapiens
399 ZRANB2 9406
Co-fractionation Homo sapiens
400 TNFAIP1 7126
Two-hybrid Homo sapiens
401 GLMN 11146
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
402 CDK18 5129
Affinity Capture-MS Homo sapiens
403 YWHAB 7529
Co-fractionation Homo sapiens
404 DMWD  
Affinity Capture-MS Homo sapiens
405 NUP98 4928
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
406 THAP7  
Two-hybrid Homo sapiens
407 TXN 7295
Co-fractionation Homo sapiens
408 TERF1 7013
Affinity Capture-MS Homo sapiens
409 MOV10 4343
Affinity Capture-RNA Homo sapiens
410 SMYD2 56950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
411 CAD 790
Affinity Capture-MS Homo sapiens
412 STK33  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
413 UPF1 5976
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
414 PINK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
415 CDC37L1  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
416 SRMS  
Affinity Capture-MS Homo sapiens
417 HSF2BP  
Two-hybrid Homo sapiens
418 LIMK2 3985
Affinity Capture-MS Homo sapiens
419 EXOSC1 51013
Two-hybrid Homo sapiens
420 ECSIT 51295
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CDC37 is involved
PathwayEvidenceSource
Constitutive Signaling by EGFRvIII TAS Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants TAS Reactome
Constitutive Signaling by Overexpressed ERBB2 TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of ERBB2 signaling TAS Reactome
Drug resistance in ERBB2 KD mutants TAS Reactome
Drug resistance in ERBB2 TMD/JMD mutants TAS Reactome
Drug-mediated inhibition of ERBB2 signaling TAS Reactome
Programmed Cell Death TAS Reactome
Regulated Necrosis TAS Reactome
Regulation of necroptotic cell death TAS Reactome
Resistance of ERBB2 KD mutants to AEE788 TAS Reactome
Resistance of ERBB2 KD mutants to afatinib TAS Reactome
Resistance of ERBB2 KD mutants to lapatinib TAS Reactome
Resistance of ERBB2 KD mutants to neratinib TAS Reactome
Resistance of ERBB2 KD mutants to osimertinib TAS Reactome
Resistance of ERBB2 KD mutants to sapitinib TAS Reactome
Resistance of ERBB2 KD mutants to tesevatinib TAS Reactome
Resistance of ERBB2 KD mutants to trastuzumab TAS Reactome
RHO GTPase cycle TAS Reactome
RHOBTB GTPase Cycle TAS Reactome
RHOBTB2 GTPase cycle TAS Reactome
RIPK1-mediated regulated necrosis TAS Reactome
Signal Transduction TAS Reactome
Signaling by EGFR in Cancer TAS Reactome
Signaling by EGFRvIII in Cancer TAS Reactome
Signaling by ERBB2 TAS Reactome
Signaling by ERBB2 ECD mutants TAS Reactome
Signaling by ERBB2 in Cancer TAS Reactome
Signaling by ERBB2 KD Mutants TAS Reactome
Signaling by ERBB2 TMD/JMD mutants TAS Reactome
Signaling by Ligand-Responsive EGFR Variants in Cancer TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome





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