Gene description for SMYD2
Gene name SET and MYND domain containing 2
Gene symbol SMYD2
Other names/aliases HSKM-B
KMT3C
ZMYND14
Species Homo sapiens
 Database cross references - SMYD2
ExoCarta ExoCarta_56950
Vesiclepedia VP_56950
Entrez Gene 56950
HGNC 20982
MIM 610663
UniProt Q9NRG4  
 SMYD2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SMYD2
Molecular Function
    RNA polymerase II complex binding GO:0000993 ISS
    p53 binding GO:0002039 IPI
    protein binding GO:0005515 IPI
    lysine N-methyltransferase activity GO:0016278 TAS
    protein-lysine N-methyltransferase activity GO:0016279 IDA
    metal ion binding GO:0046872 IEA
    histone H3K36 methyltransferase activity GO:0046975 ISS
    histone H3 methyltransferase activity GO:0140938 TAS
    histone H3K4 trimethyltransferase activity GO:0140999 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    chromatin remodeling GO:0006338 IEA
    heart development GO:0007507 IEA
    negative regulation of cell population proliferation GO:0008285 ISS
    peptidyl-lysine monomethylation GO:0018026 IDA
    peptidyl-lysine dimethylation GO:0018027 ISS
    regulation of DNA damage response, signal transduction by p53 class mediator GO:0043516 IMP
    regulation of signal transduction by p53 class mediator GO:1901796 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISS
 Experiment description of studies that identified SMYD2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SMYD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GOLGA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SNX1 6642
Co-fractionation Homo sapiens
3 CCSER1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
5 ARL1 400
Affinity Capture-MS Homo sapiens
6 ICK  
Affinity Capture-MS Homo sapiens
7 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
8 MAD2L1 4085
Affinity Capture-MS Homo sapiens
9 FOXP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 NUBP2 10101
Affinity Capture-MS Homo sapiens
11 GSK3B 2932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TP53 7157
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
13 ESR1  
Biochemical Activity Homo sapiens
14 CLASP2 23122
Affinity Capture-MS Homo sapiens
15 HIST2H3C 126961
Biochemical Activity Homo sapiens
16 JPH4 84502
Affinity Capture-MS Homo sapiens
17 RB1 5925
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
18 EPB41L3 23136
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
19 BTF3 689
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
20 AKAP11 11215
Affinity Capture-MS Homo sapiens
21 NACA 4666
Affinity Capture-MS Homo sapiens
22 PRKAA2 5563
Affinity Capture-MS Homo sapiens
23 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 CELA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ZXDC  
Affinity Capture-MS Homo sapiens
26 BEX2  
Affinity Capture-MS Homo sapiens
27 CBWD2  
Affinity Capture-MS Homo sapiens
28 IRAK1  
Affinity Capture-MS Homo sapiens
29 PSMD4 5710
Affinity Capture-MS Homo sapiens
30 PELO 53918
Affinity Capture-MS Homo sapiens
31 RPP30 10556
Affinity Capture-MS Homo sapiens
32 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
33 AXIN1  
Affinity Capture-MS Homo sapiens
34 BTF3L4 91408
Two-hybrid Homo sapiens
35 NCKAP5  
Affinity Capture-MS Homo sapiens
36 TXNDC9 10190
Affinity Capture-MS Homo sapiens
37 NXF1 10482
Affinity Capture-RNA Homo sapiens
38 PRPS2 5634
Affinity Capture-MS Homo sapiens
39 DIMT1 27292
Affinity Capture-MS Homo sapiens
40 ZBTB3  
Affinity Capture-MS Homo sapiens
41 MOV10 4343
Affinity Capture-RNA Homo sapiens
42 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GFPT1 2673
Affinity Capture-MS Homo sapiens
44 PRKAG1 5571
Affinity Capture-MS Homo sapiens
45 CPSF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 BEX1  
Affinity Capture-MS Homo sapiens
47 RPS27L 51065
Affinity Capture-MS Homo sapiens
48 PTGES3 10728
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 HSPA4L 22824
Affinity Capture-MS Homo sapiens
50 SUCLG1 8802
Affinity Capture-MS Homo sapiens
51 RPS29 6235
Affinity Capture-MS Homo sapiens
52 C1orf115  
Affinity Capture-MS Homo sapiens
53 ZFC3H1 196441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 TRMT2A 27037
Affinity Capture-MS Homo sapiens
55 MORC4  
Affinity Capture-MS Homo sapiens
56 STIP1 10963
Affinity Capture-MS Homo sapiens
57 CDC37 11140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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