Gene description for JPH4
Gene name junctophilin 4
Gene symbol JPH4
Other names/aliases JP4
JPHL1
Species Homo sapiens
 Database cross references - JPH4
ExoCarta ExoCarta_84502
Vesiclepedia VP_84502
Entrez Gene 84502
HGNC 20156
UniProt Q96JJ6  
 JPH4 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for JPH4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    regulation of cytokine production GO:0001817 IEA
    learning GO:0007612 IEA
    regulation of synaptic plasticity GO:0048167 IBA
    neuromuscular process controlling balance GO:0050885 IEA
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 TAS
    calcium ion transport into cytosol GO:0060402 TAS
    regulation of store-operated calcium entry GO:2001256 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    smooth endoplasmic reticulum GO:0005790 IEA
    plasma membrane GO:0005886 IBA
    junctional sarcoplasmic reticulum membrane GO:0014701 TAS
    junctional membrane complex GO:0030314 IBA
    dendritic shaft GO:0043198 IEA
 Experiment description of studies that identified JPH4 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for JPH4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PAXBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ZC3H18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 YPEL5 51646
Affinity Capture-MS Homo sapiens
4 FAM171A2 284069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CSNK2B 1460
Affinity Capture-MS Homo sapiens
6 UBE2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MKLN1  
Affinity Capture-MS Homo sapiens
8 MPRIP 23164
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MICAL2 9645
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 GID4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 JPH3 57338
Affinity Capture-MS Homo sapiens
12 MAEA 10296
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 WBP11  
Affinity Capture-MS Homo sapiens
14 ARMC8 25852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 RYR2 6262
FRET Homo sapiens
16 SCML1  
Affinity Capture-MS Homo sapiens
17 PRRC2C 23215
Affinity Capture-MS Homo sapiens
18 OSBPL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 VAMP3 9341
Affinity Capture-MS Homo sapiens
20 ZNF638 27332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 WDR26 80232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 UACA 55075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 PRRC2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CCDC14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 AGAP3 116988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 VANGL1 81839
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 VANGL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 OSBPL3 26031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CDK13 8621
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ARHGAP29 9411
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TJP2 9414
Affinity Capture-MS Homo sapiens
33 GCC1 79571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 IFT74 80173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 CLASRP  
Affinity Capture-MS Homo sapiens
36 MYO10 4651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 RANBP10 57610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 BCR 613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RAD18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CACNA1D  
FRET Homo sapiens
43 CLK2 1196
Affinity Capture-MS Homo sapiens
44 TRIOBP 11078
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 RBMX2  
Affinity Capture-MS Homo sapiens
46 C1QBP 708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 RMND5A 64795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 GPATCH8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 KCNN4 3783
FRET Homo sapiens
50 CACTIN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SMYD2 56950
Affinity Capture-MS Homo sapiens
52 OBSL1 23363
Affinity Capture-MS Homo sapiens
53 KBTBD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 GID8 54994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 POM121  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 IFT81 28981
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 MALSU1  
Affinity Capture-MS Homo sapiens
58 ZSWIM8 23053
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 MRS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 TMED1 11018
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 PPP1R12C 54776
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 IFT22 64792
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 DNAJC13 23317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PTPN14 5784
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JPH4 is involved
No pathways found





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