Gene description for CLK2
Gene name CDC-like kinase 2
Gene symbol CLK2
Other names/aliases -
Species Homo sapiens
 Database cross references - CLK2
ExoCarta ExoCarta_1196
Entrez Gene 1196
HGNC 2069
MIM 602989
UniProt P49760  
 CLK2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CLK2
Molecular Function
    protein tyrosine kinase activity GO:0004713 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 IEA
    protein serine/threonine kinase activity GO:0004674 IDA
Biological Process
    protein autophosphorylation GO:0046777 ISS
    regulation of RNA splicing GO:0043484 IDA
    response to ionizing radiation GO:0010212 IMP
    response to retinoic acid GO:0032526 IEA
    protein phosphorylation GO:0006468 IDA
    negative regulation of gluconeogenesis GO:0045721 ISS
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    nuclear speck GO:0016607 IEA
 Experiment description of studies that identified CLK2 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CLK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLK3  
Two-hybrid Homo sapiens
2 UBL5  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CLK2 is involved
No pathways found





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