Gene description for SON
Gene name SON DNA binding protein
Gene symbol SON
Other names/aliases BASS1
C21orf50
DBP-5
NREBP
SON3
Species Homo sapiens
 Database cross references - SON
ExoCarta ExoCarta_6651
Entrez Gene 6651
HGNC 11183
MIM 182465
UniProt P18583  
 SON identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Thymus 23844026    
 Gene ontology annotations for SON
Molecular Function
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 IDA
    poly(A) RNA binding GO:0044822 IDA
    nucleic acid binding GO:0003676 TAS
    protein binding GO:0005515 IPI
    RS domain binding GO:0050733 IEA
Biological Process
    mRNA processing GO:0006397 IDA
    regulation of cell cycle GO:0051726 IMP
    cytokinesis GO:0000910 IMP
    regulation of RNA splicing GO:0043484 IDA
    RNA splicing GO:0008380 IEA
    microtubule cytoskeleton organization GO:0000226 IMP
    negative regulation of apoptotic process GO:0043066 IDA
Subcellular Localization
    nuclear speck GO:0016607 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified SON in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SON
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAG 7532
Affinity Capture-MS Homo sapiens
2 TRIP6  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SON is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here