Gene description for JMJD6
Gene name jumonji domain containing 6
Gene symbol JMJD6
Other names/aliases PSR
PTDSR
PTDSR1
Species Homo sapiens
 Database cross references - JMJD6
ExoCarta ExoCarta_23210
Entrez Gene 23210
HGNC 19355
MIM 604914
UniProt Q6NYC1  
 JMJD6 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for JMJD6
Molecular Function
    receptor activity GO:0004872 IEA
    peptidyl-lysine 5-dioxygenase activity GO:0070815 IDA
    RNA binding GO:0003723 TAS
    protein binding GO:0005515 IPI
    iron ion binding GO:0005506 IDA
    single-stranded RNA binding GO:0003727 IDA
    histone demethylase activity (H3-R2 specific) GO:0033746 IDA
    identical protein binding GO:0042802 IPI
    histone demethylase activity (H4-R3 specific) GO:0033749 IDA
Biological Process
    histone H3-R2 demethylation GO:0070078 IDA
    oxidation-reduction process GO:0055114 IEA
    cell surface receptor signaling pathway GO:0007166 IEA
    mRNA processing GO:0006397 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    macrophage activation GO:0042116 IEA
    heart development GO:0007507 IEA
    regulation of mRNA splicing, via spliceosome GO:0048024 IMP
    transcription, DNA-templated GO:0006351 IEA
    retina development in camera-type eye GO:0060041 IEA
    RNA splicing GO:0008380 IEA
    erythrocyte development GO:0048821 IEA
    sprouting angiogenesis GO:0002040 ISS
    lung development GO:0030324 IEA
    histone H4-R3 demethylation GO:0070079 IDA
    T cell differentiation in thymus GO:0033077 IEA
    peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine GO:0018395 IDA
    recognition of apoptotic cell GO:0043654 IEA
    kidney development GO:0001822 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 IEA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified JMJD6 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for JMJD6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which JMJD6 is involved
No pathways found





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