Gene description for CCNL2
Gene name cyclin L2
Gene symbol CCNL2
Other names/aliases ANIA-6B
Species Homo sapiens
 Database cross references - CCNL2
ExoCarta ExoCarta_81669
Entrez Gene 81669
HGNC 20570
MIM 613482
UniProt Q96S94  
 CCNL2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CCNL2
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    nuclear speck GO:0016607 IEA
    nucleus GO:0005634 IDA
    cell junction GO:0030054 IDA
    nucleoplasm GO:0005654 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified CCNL2 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CCNL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2A 5430
Affinity Capture-Western Homo sapiens
2 DYRK1A  
Biochemical Activity Homo sapiens
3 CDK11A  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CCNL2 is involved
No pathways found

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