Gene description for JAK3
Gene name Janus kinase 3
Gene symbol JAK3
Other names/aliases JAK-3
JAK3_HUMAN
JAKL
L-JAK
LJAK
Species Homo sapiens
 Database cross references - JAK3
ExoCarta ExoCarta_3718
Entrez Gene 3718
HGNC 6193
MIM 600173
UniProt P52333  
 JAK3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for JAK3
Molecular Function
    protein binding GO:0005515 IPI
    protein phosphatase binding GO:0019903 IPI
    protein tyrosine kinase activity GO:0004713 TAS
    hormone receptor binding GO:0051427 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    ATP binding GO:0005524 IEA
Biological Process
    JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS
    positive regulation of dendritic cell apoptotic process GO:2000670 IEA
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IEA
    T cell homeostasis GO:0043029 TAS
    STAT protein import into nucleus GO:0007262 TAS
    response to interleukin-15 GO:0070672 TAS
    intracellular signal transduction GO:0035556 ISS
    regulation of apoptotic process GO:0042981 IBA
    cell migration GO:0016477 IBA
    response to interleukin-4 GO:0070670 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    B cell differentiation GO:0030183 ISS
    negative regulation of T cell activation GO:0050868 ISS
    protein phosphorylation GO:0006468 TAS
    negative regulation of dendritic cell cytokine production GO:0002731 ISS
    innate immune response GO:0045087 IBA
    tyrosine phosphorylation of STAT protein GO:0007260 TAS
    interleukin-4-mediated signaling pathway GO:0035771 IDA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    enzyme linked receptor protein signaling pathway GO:0007167 ISS
    response to interleukin-9 GO:0071104 TAS
    negative regulation of thymocyte apoptotic process GO:0070244 ISS
    response to interleukin-2 GO:0070669 TAS
    regulation of T cell apoptotic process GO:0070232 ISS
    negative regulation of interleukin-12 production GO:0032695 ISS
    erythrocyte differentiation GO:0030218 IBA
    negative regulation of interleukin-10 production GO:0032693 ISS
    negative regulation of T-helper 1 cell differentiation GO:0045626 ISS
    peptidyl-tyrosine autophosphorylation GO:0038083 IBA
    negative regulation of FasL biosynthetic process GO:0045221 ISS
    peptidyl-tyrosine phosphorylation GO:0018108 ISS
    positive regulation of T cell proliferation GO:0042102 IBA
Subcellular Localization
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA
    cytosol GO:0005829 TAS
    endomembrane system GO:0012505 IEA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified JAK3 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for JAK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD247 919
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
2 PTK2B 2185
Affinity Capture-Western Homo sapiens
3 IL2RB  
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
4 IL4R  
Invivo Homo sapiens
5 IL2RG  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 STAT3 6774
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
7 PRMT5 10419
Reconstituted Complex Homo sapiens
8 LEPR 3953
Affinity Capture-Western Homo sapiens
9 LCK 3932
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
10 STAT5A 6776
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
11 TIAF1  
Invivo Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
12 STAM2 10254
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
13 CXCR4 7852
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
14 JAK1 3716
Invivo Homo sapiens
15 STAT5B 6777
Two-hybrid Homo sapiens
16 PTPRC 5788
Invitro Homo sapiens
17 ALK 238
Affinity Capture-Western Homo sapiens
18 SHB  
Reconstituted Complex Homo sapiens
19 STAM 8027
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
20 IRS1 3667
Affinity Capture-Western Homo sapiens
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