Gene description for JAK3
Gene name	Janus kinase 3
Gene symbol	JAK3
Other names/aliases	JAK-3 JAK3_HUMAN JAKL L-JAK LJAK
Species	Homo sapiens
Database cross references - JAK3
ExoCarta	ExoCarta_3718
Entrez Gene	3718
HGNC	6193
MIM	600173
UniProt	P52333
JAK3 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for JAK3

Molecular Function     protein binding GO:0005515 IPI     protein phosphatase binding GO:0019903 IPI     protein tyrosine kinase activity GO:0004713 TAS     hormone receptor binding GO:0051427 IBA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA     ATP binding GO:0005524 IEA Biological Process     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     positive regulation of dendritic cell apoptotic process GO:2000670 IEA     positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IEA     T cell homeostasis GO:0043029 TAS     STAT protein import into nucleus GO:0007262 TAS     response to interleukin-15 GO:0070672 TAS     intracellular signal transduction GO:0035556 ISS     regulation of apoptotic process GO:0042981 IBA     cell migration GO:0016477 IBA     response to interleukin-4 GO:0070670 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     B cell differentiation GO:0030183 ISS     negative regulation of T cell activation GO:0050868 ISS     protein phosphorylation GO:0006468 TAS     negative regulation of dendritic cell cytokine production GO:0002731 ISS     innate immune response GO:0045087 IBA     tyrosine phosphorylation of STAT protein GO:0007260 TAS     interleukin-4-mediated signaling pathway GO:0035771 IDA     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     enzyme linked receptor protein signaling pathway GO:0007167 ISS     response to interleukin-9 GO:0071104 TAS     negative regulation of thymocyte apoptotic process GO:0070244 ISS     response to interleukin-2 GO:0070669 TAS     regulation of T cell apoptotic process GO:0070232 ISS     negative regulation of interleukin-12 production GO:0032695 ISS     erythrocyte differentiation GO:0030218 IBA     negative regulation of interleukin-10 production GO:0032693 ISS     negative regulation of T-helper 1 cell differentiation GO:0045626 ISS     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     negative regulation of FasL biosynthetic process GO:0045221 ISS     peptidyl-tyrosine phosphorylation GO:0018108 ISS     positive regulation of T cell proliferation GO:0042102 IBA Subcellular Localization     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     cytosol GO:0005829 TAS     endomembrane system GO:0012505 IEA     cytoskeleton GO:0005856 IEA