Gene description for SOCS3
Gene name	suppressor of cytokine signaling 3
Gene symbol	SOCS3
Other names/aliases	ATOD4 CIS3 Cish3 SOCS-3 SSI-3 SSI3
Species	Homo sapiens
Database cross references - SOCS3
ExoCarta	ExoCarta_9021
Vesiclepedia	VP_9021
Entrez Gene	9021
HGNC	19391
MIM	604176
UniProt	O14543
SOCS3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for SOCS3

Molecular Function     protein kinase inhibitor activity GO:0004860 TAS     protein binding GO:0005515 IPI Biological Process     spongiotrophoblast differentiation GO:0060708 IEA     branching involved in labyrinthine layer morphogenesis GO:0060670 IEA     negative regulation of protein kinase activity GO:0006469 TAS     type I interferon signaling pathway GO:0060337 TAS     regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     regulation of growth GO:0040008 IEA     negative regulation of JAK-STAT cascade GO:0046426 IBA     negative regulation of inflammatory response GO:0050728 IEA     protein ubiquitination GO:0016567 IEA     trophoblast giant cell differentiation GO:0060707 IEA     negative regulation of apoptotic process GO:0043066 IEA     regulation of type I interferon-mediated signaling pathway GO:0060338 TAS     cytokine-mediated signaling pathway GO:0019221 TAS     positive regulation of cell differentiation GO:0045597 IEA     placenta blood vessel development GO:0060674 IEA     interferon-gamma-mediated signaling pathway GO:0060333 TAS     negative regulation of insulin receptor signaling pathway GO:0046627 IBA     JAK-STAT cascade GO:0007259 TAS Subcellular Localization     cytoplasm GO:0005737 IBA     cytosol GO:0005829 TAS