Gene description for PTK2B
Gene name	protein tyrosine kinase 2 beta
Gene symbol	PTK2B
Other names/aliases	CADTK CAKB FADK2 FAK2 PKB PTK PYK2 RAFTK
Species	Homo sapiens
Database cross references - PTK2B
ExoCarta	ExoCarta_2185
Vesiclepedia	VP_2185
Entrez Gene	2185
HGNC	9612
MIM	601212
UniProt	Q14289
PTK2B identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for PTK2B

Molecular Function     non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA     calmodulin-dependent protein kinase activity GO:0004683 ISS     protein complex binding GO:0032403 IEA     protein tyrosine kinase activity GO:0004713 TAS     signal transducer activity GO:0004871 NAS     receptor binding GO:0005102 IBA     3-phosphoinositide-dependent protein kinase binding GO:0043423 IEA     N-methyl-D-aspartate selective glutamate receptor activity GO:0004972 ISS     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA Biological Process     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISS     cellular defense response GO:0006968 ISS     regulation of inositol trisphosphate biosynthetic process GO:0032960 ISS     positive regulation of nitric-oxide synthase activity GO:0051000 IEA     positive regulation of actin filament polymerization GO:0030838 IMP     response to hypoxia GO:0001666 IEA     positive regulation of translation GO:0045727 IEA     regulation of macrophage chemotaxis GO:0010758 ISS     positive regulation of JNK cascade GO:0046330 IMP     positive regulation of cell-matrix adhesion GO:0001954 IMP     negative regulation of muscle cell apoptotic process GO:0010656 IEA     positive regulation of JUN kinase activity GO:0043507 IEA     positive regulation of protein kinase activity GO:0045860 IMP     peptidyl-tyrosine autophosphorylation GO:0038083 ISS     positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 IEA     response to lithium ion GO:0010226 IEA     positive regulation of cytosolic calcium ion concentration GO:0007204 IEA     response to immobilization stress GO:0035902 IEA     response to drug GO:0042493 IEA     negative regulation of bone mineralization GO:0030502 ISS     innate immune response GO:0045087 IBA     positive regulation of cell proliferation GO:0008284 IMP     regulation of calcium-mediated signaling GO:0050848 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     marginal zone B cell differentiation GO:0002315 ISS     activation of Janus kinase activity GO:0042976 IMP     neuron projection development GO:0031175 IEA     positive regulation of B cell chemotaxis GO:2000538 ISS     regulation of actin cytoskeleton reorganization GO:2000249 ISS     blood vessel endothelial cell migration GO:0043534 IEA     positive regulation of endothelial cell migration GO:0010595 IDA     positive regulation of cell growth GO:0030307 IEA     ionotropic glutamate receptor signaling pathway GO:0035235 ISS     response to calcium ion GO:0051592 IEA     response to cocaine GO:0042220 IEA     angiogenesis GO:0001525 IBA     protein phosphorylation GO:0006468 TAS     cell migration GO:0016477 IBA     signal transduction GO:0007165 TAS     signal complex assembly GO:0007172 IEA     protein autophosphorylation GO:0046777 TAS     regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000310 ISS     sprouting angiogenesis GO:0002040 ISS     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISS     negative regulation of potassium ion transport GO:0043267 IDA     response to hormone GO:0009725 IEA     cytoskeleton organization GO:0007010 IBA     regulation of nitric oxide biosynthetic process GO:0045428 IEA     apoptotic process GO:0006915 TAS     response to osmotic stress GO:0006970 IEA     chemokine-mediated signaling pathway GO:0070098 ISS     regulation of cell adhesion GO:0030155 IMP     negative regulation of cell proliferation GO:0008285 IMP     regulation of cGMP biosynthetic process GO:0030826 IEA     long-term synaptic potentiation GO:0060291 ISS     response to glucose GO:0009749 IEA     response to cAMP GO:0051591 IEA     tumor necrosis factor-mediated signaling pathway GO:0033209 IMP     response to ethanol GO:0045471 IEA     focal adhesion assembly GO:0048041 IEA     response to mechanical stimulus GO:0009612 IEA     oocyte maturation GO:0001556 IEA     cell differentiation GO:0030154 IBA     bone resorption GO:0045453 ISS     protein complex assembly GO:0006461 TAS     response to hydrogen peroxide GO:0042542 IEA     negative regulation of apoptotic process GO:0043066 IMP     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     integrin-mediated signaling pathway GO:0007229 IMP     response to stress GO:0006950 TAS     positive regulation of reactive oxygen species metabolic process GO:2000379 IEA     regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000058 IDA     cell adhesion GO:0007155 IBA     regulation of release of sequestered calcium ion into cytosol GO:0051279 ISS     positive regulation of neuron projection development GO:0010976 IMP     epidermal growth factor receptor signaling pathway GO:0007173 IBA     cell surface receptor signaling pathway GO:0007166 IMP     MAPK cascade GO:0000165 IEA     negative regulation of myeloid cell differentiation GO:0045638 IMP     positive regulation of excitatory postsynaptic membrane potential GO:2000463 ISS     regulation of cGMP-mediated signaling GO:0010752 IEA     cellular response to retinoic acid GO:0071300 IMP     regulation of establishment of cell polarity GO:2000114 ISS     positive regulation of cell migration GO:0030335 IMP     regulation of cell shape GO:0008360 IMP     positive regulation of angiogenesis GO:0045766 IEA     stress fiber assembly GO:0043149 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     negative regulation of neuron apoptotic process GO:0043524 ISS     glial cell proliferation GO:0014009 IEA Subcellular Localization     lamellipodium GO:0030027 IDA     nucleoplasm GO:0005654 IDA     neuronal cell body GO:0043025 ISS     cytosol GO:0005829 TAS     membrane raft GO:0045121 IEA     dendrite GO:0030425 ISS     nucleus GO:0005634 IDA     axon GO:0030424 IEA     cell cortex GO:0005938 IEA     cytoskeleton GO:0005856 IEA     perinuclear region of cytoplasm GO:0048471 IDA     N-methyl-D-aspartate selective glutamate receptor complex GO:0017146 ISS     cytoplasm GO:0005737 IDA     growth cone GO:0030426 ISS     cell body GO:0044297 ISS     apical dendrite GO:0097440 ISS     focal adhesion GO:0005925 IDA     postsynaptic density GO:0014069 ISS     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA