Gene description for PITPNM1
Gene name phosphatidylinositol transfer protein, membrane-associated 1
Gene symbol PITPNM1
Other names/aliases DRES9
NIR2
PITPNM
RDGB
RDGB1
RDGBA
RDGBA1
Rd9
Species Homo sapiens
 Database cross references - PITPNM1
ExoCarta ExoCarta_9600
Entrez Gene 9600
HGNC 9003
MIM 608794
UniProt O00562  
 PITPNM1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for PITPNM1
Molecular Function
    phosphatidylinositol transporter activity GO:0008526 TAS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    phototransduction GO:0007602 TAS
    protein transport GO:0015031 IEA
    brain development GO:0007420 TAS
    phospholipid transport GO:0015914 TAS
    lipid metabolic process GO:0006629 NAS
Subcellular Localization
    cleavage furrow GO:0032154 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    lipid particle GO:0005811 IEA
    cytoplasm GO:0005737 IDA
    midbody GO:0030496 IEA
    membrane GO:0016020 TAS
    Golgi cisterna membrane GO:0032580 IEA
 Experiment description of studies that identified PITPNM1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PITPNM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDK1 983
Affinity Capture-MS Homo sapiens
2 RHOA 387
Affinity Capture-MS Homo sapiens
3 PTK2B 2185
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 PLK1 5347
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PITPNM1 is involved
No pathways found





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