Gene description for LPXN
Gene name leupaxin
Gene symbol LPXN
Other names/aliases LDPL
Species Homo sapiens
 Database cross references - LPXN
ExoCarta ExoCarta_9404
Vesiclepedia VP_9404
Entrez Gene 9404
HGNC 14061
MIM 605390
UniProt O60711  
 LPXN identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LPXN
Molecular Function
    transcription coregulator activity GO:0003712 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    cell adhesion GO:0007155 NAS
    negative regulation of cell adhesion GO:0007162 IDA
    signal transduction GO:0007165 TAS
    transforming growth factor beta receptor signaling pathway GO:0007179 IBA
    regulation of cell adhesion mediated by integrin GO:0033628 IEA
    substrate adhesion-dependent cell spreading GO:0034446 IBA
    endothelial cell migration GO:0043542 IBA
    negative regulation of B cell receptor signaling pathway GO:0050859 IBA
    negative regulation of B cell receptor signaling pathway GO:0050859 IDA
    protein-containing complex assembly GO:0065003 TAS
Subcellular Localization
    podosome GO:0002102 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    focal adhesion GO:0005925 IDA
    membrane GO:0016020 HDA
    nuclear speck GO:0016607 IDA
    cell projection GO:0042995 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified LPXN in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LPXN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Two-hybrid Homo sapiens
2 PLEKHH2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZNF175  
Two-hybrid Homo sapiens
4 BTK 695
Affinity Capture-MS Homo sapiens
5 TRIP6 7205
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PDLIM7 9260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 NUP54 53371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 KIF1B 23095
Affinity Capture-MS Homo sapiens
9 SPECC1L 23384
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ARHGEF7 8874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 AGXT  
Two-hybrid Homo sapiens
12 CCDC6 8030
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DCP1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CEP68 23177
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ATXN2 6311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 IKBKG 8517
Reconstituted Complex Homo sapiens
17 ZYX 7791
Affinity Capture-MS Homo sapiens
18 HDAC6 10013
Two-hybrid Homo sapiens
19 AQP1 358
Two-hybrid Homo sapiens
20 TXLNB  
Two-hybrid Homo sapiens
21 LIMS1 3987
Two-hybrid Homo sapiens
22 MIB1 57534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PAK1 5058
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 POM121  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
25 RBMS1 5937
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PTK2 5747
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 EDC3 80153
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PLEKHH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 HOXA1 3198
Two-hybrid Homo sapiens
30 ZNF426  
Two-hybrid Homo sapiens
31 TNS2 23371
Two-hybrid Homo sapiens
32 Hoxa1  
Two-hybrid Mus musculus
PCA Mus musculus
Affinity Capture-Western Mus musculus
33 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 RUNX1T1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
35 MAPK6  
Two-hybrid Homo sapiens
36 RNF214  
Two-hybrid Homo sapiens
37 HOXC9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 MIOS 54468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PCNT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 VCL 7414
Two-hybrid Homo sapiens
41 GIT2 9815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PSTPIP2 9050
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 TGFB1 7040
Two-hybrid Homo sapiens
44 PTPN12 5782
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PTK2B 2185
Affinity Capture-Western Homo sapiens
46 PHF21A  
Two-hybrid Homo sapiens
47 IMP3 55272
Two-hybrid Homo sapiens
48 LIMD1 8994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ZNF281  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ARHGEF6 9459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PARVA 55742
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 LMO1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
53 PCM1 5108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 QRICH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PLEKHN1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
56 LPP 4026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 RBCK1  
Co-fractionation Homo sapiens
58 NDN 4692
Two-hybrid Homo sapiens
59 PAK2 5062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SFI1 9814
Two-hybrid Homo sapiens
61 GIT1 28964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 PLSCR4  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LPXN is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here