Gene description for LPXN
Gene name leupaxin
Gene symbol LPXN
Other names/aliases LDPL
Species Homo sapiens
 Database cross references - LPXN
ExoCarta ExoCarta_9404
Vesiclepedia VP_9404
Entrez Gene 9404
HGNC 14061
MIM 605390
UniProt O60711  
 LPXN identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LPXN
Molecular Function
    transcription cofactor activity GO:0003712 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    regulation of cell adhesion mediated by integrin GO:0033628 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription, DNA-templated GO:0006351 IEA
    protein complex assembly GO:0006461 TAS
    negative regulation of cell adhesion GO:0007162 IDA
    negative regulation of B cell receptor signaling pathway GO:0050859 IDA
    cell adhesion GO:0007155 IEA
    signal transduction GO:0007165 TAS
Subcellular Localization
    cell projection GO:0042995 IEA
    membrane GO:0016020 IDA
    podosome GO:0002102 IDA
    focal adhesion GO:0005925 IDA
    cytoplasm GO:0005737 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified LPXN in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LPXN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF426  
Two-hybrid Homo sapiens
2 LIMS1 3987
Two-hybrid Homo sapiens
3 POM121  
Two-hybrid Homo sapiens
4 HOXA1 3198
Two-hybrid Homo sapiens
5 PTK2B 2185
Affinity Capture-Western Homo sapiens
6 PHF21A  
Two-hybrid Homo sapiens
7 IMP3 55272
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LPXN is involved
No pathways found





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