Gene description for PARVA
Gene name parvin, alpha
Gene symbol PARVA
Other names/aliases CH-ILKBP
MXRA2
Species Homo sapiens
 Database cross references - PARVA
ExoCarta ExoCarta_55742
Entrez Gene 55742
HGNC 14652
MIM 608120
UniProt Q9NVD7  
 PARVA identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PARVA
Molecular Function
    protein binding GO:0005515 IPI
    actin binding GO:0003779 IEA
Biological Process
    outflow tract septum morphogenesis GO:0003148 ISS
    actin-mediated cell contraction GO:0070252 ISS
    cell junction assembly GO:0034329 TAS
    regulation of cell shape GO:0008360 IEA
    smooth muscle cell chemotaxis GO:0071670 ISS
    establishment or maintenance of cell polarity GO:0007163 ISS
    substrate adhesion-dependent cell spreading GO:0034446 IMP
    cilium morphogenesis GO:0060271 IMP
    sprouting angiogenesis GO:0002040 ISS
    actin cytoskeleton reorganization GO:0031532 IEA
    heterotypic cell-cell adhesion GO:0034113 ISS
Subcellular Localization
    actin cytoskeleton GO:0015629 IDA
    focal adhesion GO:0005925 IDA
    plasma membrane GO:0005886 IEA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    Z disc GO:0030018 IEA
 Experiment description of studies that identified PARVA in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PARVA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DHX36 170506
Affinity Capture-MS Homo sapiens
2 ILK 3611
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here