Gene description for OTUD6B
Gene name OTU domain containing 6B
Gene symbol OTUD6B
Other names/aliases CGI-77
DUBA-5
DUBA5
Species Homo sapiens
 Database cross references - OTUD6B
ExoCarta ExoCarta_51633
Vesiclepedia VP_51633
Entrez Gene 51633
HGNC 24281
MIM 612021
UniProt Q8N6M0  
 OTUD6B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for OTUD6B
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IBA
    cysteine-type deubiquitinase activity GO:0004843 IDA
    protein binding GO:0005515 IPI
Biological Process
    proteolysis GO:0006508 IEA
    cell population proliferation GO:0008283 IDA
    protein deubiquitination GO:0016579 IDA
    protein deubiquitination GO:0016579 IMP
    negative regulation of translation GO:0017148 IMP
    proteasome assembly GO:0043248 IMP
    positive regulation of translation GO:0045727 IMP
Subcellular Localization
    eukaryotic translation initiation factor 4F complex GO:0016281 IDA
 Experiment description of studies that identified OTUD6B in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for OTUD6B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MTDH 92140
Affinity Capture-MS Homo sapiens
2 ASCC3 10973
Affinity Capture-MS Homo sapiens
3 CHD3 1107
Co-fractionation Homo sapiens
4 FAS 355
Proximity Label-MS Homo sapiens
5 EIF4G1 1981
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 MYH14 79784
Co-fractionation Homo sapiens
7 DLD 1738
Co-fractionation Homo sapiens
8 LIMCH1 22998
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 Ttll12 223723
Affinity Capture-MS Mus musculus
10 Rmdn3  
Affinity Capture-MS Mus musculus
11 SPC24 147841
Co-fractionation Homo sapiens
12 Oxnad1  
Affinity Capture-MS Mus musculus
13 SMURF1 57154
Biochemical Activity Homo sapiens
14 EIF4A1 1973
Affinity Capture-Western Homo sapiens
15 UBC 7316
Reconstituted Complex Homo sapiens
16 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
17 VHL  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
18 SULT1A3 6818
Affinity Capture-MS Homo sapiens
19 PTK2 5747
Co-fractionation Homo sapiens
20 OTUB1 55611
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
21 BASP1 10409
Co-fractionation Homo sapiens
22 AP2M1 1173
Co-fractionation Homo sapiens
23 APEX1 328
Co-fractionation Homo sapiens
24 Syce2  
Affinity Capture-MS Mus musculus
25 BTBD2  
Affinity Capture-MS Homo sapiens
26 BTBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 Pip4k2c  
Affinity Capture-MS Mus musculus
28 CORO1B 57175
Co-fractionation Homo sapiens
29 EIF4E 1977
Affinity Capture-Western Homo sapiens
30 MYH9 4627
Co-fractionation Homo sapiens
31 HDDC2 51020
Co-fractionation Homo sapiens
32 AKAP5  
Affinity Capture-MS Homo sapiens
33 GALC 2581
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 Kif13b  
Affinity Capture-MS Mus musculus
35 SEC24C 9632
Co-fractionation Homo sapiens
36 METAP2 10988
Affinity Capture-MS Homo sapiens
37 TCEB2 6923
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
38 MCTS1 28985
Co-fractionation Homo sapiens
39 PARVA 55742
Co-fractionation Homo sapiens
40 RPF2 84154
Affinity Capture-MS Homo sapiens
41 SWAP70 23075
Co-fractionation Homo sapiens
42 CRMP1 1400
Co-fractionation Homo sapiens
43 EIF4B 1975
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which OTUD6B is involved
No pathways found





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