Gene description for CRMP1
Gene name collapsin response mediator protein 1
Gene symbol CRMP1
Other names/aliases CRMP-1
DPYSL1
DRP-1
DRP1
ULIP-3
Species Homo sapiens
 Database cross references - CRMP1
ExoCarta ExoCarta_1400
Vesiclepedia VP_1400
Entrez Gene 1400
HGNC 2365
MIM 602462
UniProt Q14194  
 CRMP1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CRMP1
Molecular Function
    protein binding GO:0005515 IPI
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016810 IEA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IEA
    axon guidance GO:0007411 TAS
    nervous system development GO:0007399 TAS
    nucleobase-containing compound metabolic process GO:0006139 TAS
Subcellular Localization
    neuronal cell body GO:0043025 IEA
    spindle GO:0005819 IEA
    cytoplasm GO:0005737 IDA
    dendrite GO:0030425 IEA
    cytosol GO:0005829 TAS
    microtubule organizing center GO:0005815 IEA
 Experiment description of studies that identified CRMP1 in exosomes
1
Experiment ID 224
MISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101|CD63|CD81
EV Enriched markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CRMP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Two-hybrid Homo sapiens
2 TRIP13 9319
Two-hybrid Homo sapiens
3 TFG 10342
Two-hybrid Homo sapiens
4 SAT  
Two-hybrid Homo sapiens
5 ZNF24  
Two-hybrid Homo sapiens
6 TK1 7083
Two-hybrid Homo sapiens
7 SNRPG 6637
Two-hybrid Homo sapiens
8 NAT9  
Two-hybrid Homo sapiens
9 CCT7 10574
Two-hybrid Homo sapiens
10 RGL2 5863
Two-hybrid Homo sapiens
11 MRPS12  
Two-hybrid Homo sapiens
12 HMGB1 3146
Two-hybrid Homo sapiens
13 FAS 355
Two-hybrid Homo sapiens
14 SERPINB9 5272
Two-hybrid Homo sapiens
15 KLHL20  
Two-hybrid Homo sapiens
16 AXIN1  
Two-hybrid Homo sapiens
17 PFN1 5216
Two-hybrid Homo sapiens
18 FXR1 8087
Two-hybrid Homo sapiens
19 RPA2 6118
Two-hybrid Homo sapiens
20 CDK5RAP2 55755
Two-hybrid Homo sapiens
21 ARL15 54622
Two-hybrid Homo sapiens
22 RHOA 387
Phenotypic Suppression Homo sapiens
23 ALDH2 217
Two-hybrid Homo sapiens
24 HNRNPH3 3189
Two-hybrid Homo sapiens
25 HSU79303  
Two-hybrid Homo sapiens
26 MOB4 25843
Two-hybrid Homo sapiens
27 PSMD11 5717
Two-hybrid Homo sapiens
28 FTH1 2495
Two-hybrid Homo sapiens
29 HNRNPUL1 11100
Two-hybrid Homo sapiens
30 RTN4 57142
Two-hybrid Homo sapiens
31 PMF1  
Two-hybrid Homo sapiens
32 CCL18  
Two-hybrid Homo sapiens
33 BTBD2  
Two-hybrid Homo sapiens
34 FUBP1 8880
Two-hybrid Homo sapiens
35 LRRC1 55227
Two-hybrid Homo sapiens
36 PAFAH1B3 5050
Two-hybrid Homo sapiens
37 DPYSL2 1808
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
38 EEF1D 1936
Two-hybrid Homo sapiens
39 EPN1 29924
Two-hybrid Homo sapiens
40 CDK5RAP3 80279
Two-hybrid Homo sapiens
41 AGR2 10551
Two-hybrid Homo sapiens
42 HSPE1 3336
Two-hybrid Homo sapiens
43 EIF2S2 8894
Two-hybrid Homo sapiens
44 LSM2  
Two-hybrid Homo sapiens
45 NDUFV2 4729
Two-hybrid Homo sapiens
46 UBE2B 7320
Two-hybrid Homo sapiens
47 NVL  
Two-hybrid Homo sapiens
48 SEPHS1 22929
Two-hybrid Homo sapiens
49 PPP1R8 5511
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CRMP1 is involved
PathwayEvidenceSource
CRMPs in Sema3A signaling TAS Reactome





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