Gene description for CRMP1
Gene name collapsin response mediator protein 1
Gene symbol CRMP1
Other names/aliases CRMP-1
DPYSL1
DRP-1
DRP1
ULIP-3
Species Homo sapiens
 Database cross references - CRMP1
ExoCarta ExoCarta_1400
Entrez Gene 1400
HGNC 2365
MIM 602462
UniProt Q14194  
 CRMP1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CRMP1
Molecular Function
    protein binding GO:0005515 IPI
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016810 IEA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IEA
    axon guidance GO:0007411 TAS
    nervous system development GO:0007399 TAS
    nucleobase-containing compound metabolic process GO:0006139 TAS
Subcellular Localization
    neuronal cell body GO:0043025 IEA
    spindle GO:0005819 IEA
    cytoplasm GO:0005737 IDA
    dendrite GO:0030425 IEA
    cytosol GO:0005829 TAS
    microtubule organizing center GO:0005815 IEA
 Experiment description of studies that identified CRMP1 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CRMP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Two-hybrid Homo sapiens
2 NDUFV2  
Two-hybrid Homo sapiens
3 RGL2  
Two-hybrid Homo sapiens
4 TRIP13 9319
Two-hybrid Homo sapiens
5 TFG 10342
Two-hybrid Homo sapiens
6 SAT  
Two-hybrid Homo sapiens
7 ZNF24  
Two-hybrid Homo sapiens
8 SNRPG 6637
Two-hybrid Homo sapiens
9 SEPHS1  
Two-hybrid Homo sapiens
10 NAT9  
Two-hybrid Homo sapiens
11 CCT7 10574
Two-hybrid Homo sapiens
12 TK1 7083
Two-hybrid Homo sapiens
13 MRPS12  
Two-hybrid Homo sapiens
14 HMGB1 3146
Two-hybrid Homo sapiens
15 FAS 355
Two-hybrid Homo sapiens
16 SERPINB9 5272
Two-hybrid Homo sapiens
17 KLHL20  
Two-hybrid Homo sapiens
18 AXIN1  
Two-hybrid Homo sapiens
19 PFN1 5216
Two-hybrid Homo sapiens
20 FXR1 8087
Two-hybrid Homo sapiens
21 RPA2 6118
Two-hybrid Homo sapiens
22 CDK5RAP2 55755
Two-hybrid Homo sapiens
23 ARL15 54622
Two-hybrid Homo sapiens
24 ALDH2 217
Two-hybrid Homo sapiens
25 HNRNPH3 3189
Two-hybrid Homo sapiens
26 HSU79303  
Two-hybrid Homo sapiens
27 EPN1  
Two-hybrid Homo sapiens
28 PSMD11 5717
Two-hybrid Homo sapiens
29 FTH1 2495
Two-hybrid Homo sapiens
30 EIF2S2 8894
Two-hybrid Homo sapiens
31 RTN4 57142
Two-hybrid Homo sapiens
32 PMF1  
Two-hybrid Homo sapiens
33 CCL18  
Two-hybrid Homo sapiens
34 BTBD2  
Two-hybrid Homo sapiens
35 PREI3  
Two-hybrid Homo sapiens
36 FUBP1 8880
Two-hybrid Homo sapiens
37 LRRC1 55227
Two-hybrid Homo sapiens
38 PAFAH1B3 5050
Two-hybrid Homo sapiens
39 DPYSL2 1808
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
40 EEF1D 1936
Two-hybrid Homo sapiens
41 CDK5RAP3  
Two-hybrid Homo sapiens
42 AGR2 10551
Two-hybrid Homo sapiens
43 HSPE1 3336
Two-hybrid Homo sapiens
44 HNRNPUL1 11100
Two-hybrid Homo sapiens
45 LSM2  
Two-hybrid Homo sapiens
46 RHOA 387
Phenotypic Suppression Homo sapiens
47 UBE2B 7320
Two-hybrid Homo sapiens
48 NVL  
Two-hybrid Homo sapiens
49 PPP1R8 5511
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CRMP1 is involved
PathwayEvidenceSource
CRMPs in Sema3A signaling TAS Reactome





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