Gene description for DPYSL4
Gene name dihydropyrimidinase-like 4
Gene symbol DPYSL4
Other names/aliases CRMP3
DRP-4
ULIP4
Species Homo sapiens
 Database cross references - DPYSL4
ExoCarta ExoCarta_10570
Vesiclepedia VP_10570
Entrez Gene 10570
HGNC 3016
MIM 608407
UniProt O14531  
 DPYSL4 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DPYSL4
Molecular Function
    dihydropyrimidinase activity GO:0004157 IBA
    protein binding GO:0005515 IPI
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0016812 IBA
    filamin binding GO:0031005 IPI
Biological Process
    pyrimidine nucleobase catabolic process GO:0006208 IBA
    nervous system development GO:0007399 TAS
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified DPYSL4 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DPYSL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 WDFY3 23001
Affinity Capture-MS Homo sapiens
2 TRIP13 9319
Two-hybrid Homo sapiens
3 MECP2 4204
Affinity Capture-MS Homo sapiens
4 DNAAF2  
Affinity Capture-MS Homo sapiens
5 NTRK1 4914
Affinity Capture-MS Homo sapiens
6 RBPMS 11030
Two-hybrid Homo sapiens
7 LIPH 200879
Affinity Capture-MS Homo sapiens
8 DOCK5 80005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TUBB 615087
Affinity Capture-Western Bos taurus
10 DPYSL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KLHL8  
Affinity Capture-MS Homo sapiens
12 GPM6A 2823
Affinity Capture-MS Homo sapiens
13 SH3GL1 6455
Two-hybrid Homo sapiens
14 CTAG1B  
Affinity Capture-MS Homo sapiens
15 KLHDC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LGALS7B 653499
Affinity Capture-MS Homo sapiens
17 ACTC1 70
Proximity Label-MS Homo sapiens
18 SKP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DGUOK  
Affinity Capture-MS Homo sapiens
20 DPYSL3 1809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DPYS 1807
Affinity Capture-MS Homo sapiens
22 LGALS7 3963
Affinity Capture-MS Homo sapiens
23 TUBA1A 404053
Affinity Capture-Western Bos taurus
24 MAP4K2  
Affinity Capture-MS Homo sapiens
25 TRIM54  
Two-hybrid Homo sapiens
26 TFCP2 7024
Affinity Capture-MS Homo sapiens
27 SH3GL3  
Two-hybrid Homo sapiens
28 S100A4 6275
Affinity Capture-MS Homo sapiens
29 ARHGAP25  
Affinity Capture-MS Homo sapiens
30 UBP1 7342
Affinity Capture-MS Homo sapiens
31 MMAB 326625
Affinity Capture-MS Homo sapiens
32 USP47 55031
Affinity Capture-MS Homo sapiens
33 SYNJ2BP 55333
Affinity Capture-MS Homo sapiens
34 DPYSL2 1808
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
35 CBWD3  
Affinity Capture-MS Homo sapiens
36 OLFM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 NUFIP1  
Affinity Capture-MS Homo sapiens
38 ATPAF2 91647
Affinity Capture-MS Homo sapiens
39 BICD2 23299
Proximity Label-MS Homo sapiens
40 F9 2158
Affinity Capture-MS Homo sapiens
41 HAX1  
Affinity Capture-MS Homo sapiens
42 PRDX2 7001
Affinity Capture-MS Homo sapiens
43 PLCG1 5335
Affinity Capture-MS Homo sapiens
44 DEF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PTPRO 5800
Two-hybrid Homo sapiens
47 SH3GL2  
Two-hybrid Homo sapiens
48 CRMP1 1400
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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