Gene description for PTPRO
Gene name protein tyrosine phosphatase, receptor type, O
Gene symbol PTPRO
Other names/aliases GLEPP1
NPHS6
PTP-OC
PTP-U2
PTPROT
PTPU2
R-PTP-O
Species Homo sapiens
 Database cross references - PTPRO
ExoCarta ExoCarta_5800
Entrez Gene 5800
HGNC 9678
MIM 600579
UniProt Q16827  
 PTPRO identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for PTPRO
Molecular Function
    phosphatase activity GO:0016791 ISS
    protein binding GO:0005515 IPI
    transmembrane receptor protein tyrosine phosphatase activity GO:0005001 NAS
    Wnt-protein binding GO:0017147 ISS
    protein tyrosine phosphatase activity GO:0004725 TAS
    protein homodimerization activity GO:0042803 ISS
Biological Process
    peptidyl-tyrosine dephosphorylation GO:0035335 IMP
    regulation of glomerular filtration GO:0003093 ISS
    protein dephosphorylation GO:0006470 TAS
    glomerular visceral epithelial cell differentiation GO:0072112 ISS
    cell morphogenesis GO:0000902 ISS
    lamellipodium assembly GO:0030032 ISS
    negative regulation of retinal ganglion cell axon guidance GO:0090260 ISS
    negative regulation of neuron projection development GO:0010977 ISS
    glomerulus development GO:0032835 IMP
    monocyte chemotaxis GO:0002548 IMP
    negative regulation of cell-substrate adhesion GO:0010812 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISS
    negative regulation of glomerular filtration GO:0003105 ISS
    axon guidance GO:0007411 ISS
    slit diaphragm assembly GO:0036060 NAS
Subcellular Localization
    axon GO:0030424 ISS
    dendritic spine GO:0043197 ISS
    lateral plasma membrane GO:0016328 ISS
    integral component of plasma membrane GO:0005887 NAS
    neuron projection GO:0043005 ISS
    integral component of membrane GO:0016021 TAS
    extracellular exosome GO:0070062 IDA
    lamellipodium GO:0030027 ISS
    plasma membrane GO:0005886 ISS
    apical plasma membrane GO:0016324 ISS
    growth cone GO:0030426 ISS
 Experiment description of studies that identified PTPRO in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPRO
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KIT 3815
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which PTPRO is involved
No pathways found





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