Gene description for TMX4
Gene name thioredoxin-related transmembrane protein 4
Gene symbol TMX4
Other names/aliases DJ971N18.2
PDIA14
TXNDC13
Species Homo sapiens
 Database cross references - TMX4
ExoCarta ExoCarta_56255
Vesiclepedia VP_56255
Entrez Gene 56255
HGNC 25237
UniProt Q9H1E5  
 TMX4 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TMX4
Molecular Function
    disulfide oxidoreductase activity GO:0015036 IBA
Subcellular Localization
    nuclear inner membrane GO:0005637 ISS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    endomembrane system GO:0012505 IBA
 Experiment description of studies that identified TMX4 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMX4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH13 1012
Affinity Capture-MS Homo sapiens
2 ADAM18  
Affinity Capture-MS Homo sapiens
3 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TMEM106A  
Affinity Capture-MS Homo sapiens
7 HSD3B7 80270
Proximity Label-MS Homo sapiens
8 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CHRNA4  
Affinity Capture-MS Homo sapiens
10 RPN2 6185
Proximity Label-MS Homo sapiens
11 CKAP4 10970
Proximity Label-MS Homo sapiens
12 HSD11B1 3290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 METTL7A 25840
Proximity Label-MS Homo sapiens
14 LRRC59 55379
Proximity Label-MS Homo sapiens
15 LDLRAD1  
Affinity Capture-MS Homo sapiens
16 DUOXA2  
Affinity Capture-MS Homo sapiens
17 SMIM5  
Affinity Capture-MS Homo sapiens
18 TYROBP  
Affinity Capture-MS Homo sapiens
19 HPN  
Affinity Capture-MS Homo sapiens
20 MCOLN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 IL9R  
Affinity Capture-MS Homo sapiens
23 BCAP31 10134
Proximity Label-MS Homo sapiens
24 ATP1B4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 C9orf78 51759
Affinity Capture-MS Homo sapiens
26 STIM1 6786
Proximity Label-MS Homo sapiens
27 HSD17B11 51170
Proximity Label-MS Homo sapiens
28 EMD 2010
Proximity Label-MS Homo sapiens
29 PARK2  
Affinity Capture-MS Homo sapiens
30 GPR114  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PTPN1 5770
Proximity Label-MS Homo sapiens
32 STX4 6810
Proximity Label-MS Homo sapiens
33 ELOVL5 60481
Proximity Label-MS Homo sapiens
34 IFNLR1  
Affinity Capture-MS Homo sapiens
35 KIAA1467 57613
Affinity Capture-MS Homo sapiens
36 TOMM22 56993
Co-fractionation Homo sapiens
37 CD226 10666
Affinity Capture-MS Homo sapiens
38 EREG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 KRTCAP3 200634
Affinity Capture-MS Homo sapiens
40 B3GAT1  
Proximity Label-MS Homo sapiens
41 ST14 6768
Affinity Capture-MS Homo sapiens
42 SEC61B 10952
Proximity Label-MS Homo sapiens
43 BTN2A1 11120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SEC62 7095
Proximity Label-MS Homo sapiens
45 ATP1B3 483
Affinity Capture-MS Homo sapiens
46 IGSF8 93185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 IL27RA 9466
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RPN1 6184
Proximity Label-MS Homo sapiens
49 DNAJC1 64215
Proximity Label-MS Homo sapiens
50 SSR1 6745
Proximity Label-MS Homo sapiens
51 VASN 114990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TEX29  
Affinity Capture-MS Homo sapiens
53 PTPRO 5800
Affinity Capture-MS Homo sapiens
54 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 CHST5  
Affinity Capture-MS Homo sapiens
56 FUT1  
Affinity Capture-MS Homo sapiens
57 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 DERL1 79139
Proximity Label-MS Homo sapiens
59 CCDC47 57003
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMX4 is involved
No pathways found





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