Gene description for DERL1
Gene name derlin 1
Gene symbol DERL1
Other names/aliases DER-1
DER1
Species Homo sapiens
 Database cross references - DERL1
ExoCarta ExoCarta_79139
Entrez Gene 79139
HGNC 28454
MIM 608813
UniProt Q9BUN8  
 DERL1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for DERL1
Molecular Function
    protease binding GO:0002020 IPI
    receptor activity GO:0004872 NAS
    protein binding GO:0005515 IPI
    MHC class I protein binding GO:0042288 IDA
    ATPase binding GO:0051117 IPI
Biological Process
    positive regulation of protein ubiquitination GO:0031398 IDA
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 TAS
    ER-associated misfolded protein catabolic process GO:0071712 IMP
    endoplasmic reticulum unfolded protein response GO:0030968 IDA
    response to unfolded protein GO:0006986 IMP
    establishment of protein localization GO:0045184 TAS
    intracellular transport of viral protein in host cell GO:0019060 TAS
    retrograde protein transport, ER to cytosol GO:0030970 IMP
    positive regulation of protein binding GO:0032092 IMP
    protein homooligomerization GO:0051260 IDA
    protein destabilization GO:0031648 IMP
Subcellular Localization
    VCP-NPL4-UFD1 AAA ATPase complex GO:0034098 TAS
    late endosome GO:0005770 IEA
    host cell GO:0043657 TAS
    integral component of membrane GO:0016021 IDA
    early endosome GO:0005769 IEA
    endoplasmic reticulum GO:0005783 IMP
    Hrd1p ubiquitin ligase complex GO:0000836 IDA
    integral component of endoplasmic reticulum membrane GO:0030176 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified DERL1 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DERL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SELS  
Affinity Capture-Western Homo sapiens
2 HLA-A  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which DERL1 is involved
No pathways found





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