Gene description for SYAP1
Gene name synapse associated protein 1
Gene symbol SYAP1
Other names/aliases PRO3113
Species Homo sapiens
 Database cross references - SYAP1
ExoCarta ExoCarta_94056
Vesiclepedia VP_94056
Entrez Gene 94056
HGNC 16273
UniProt Q96A49  
 SYAP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for SYAP1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell differentiation GO:0030154 IEA
    cellular response to insulin stimulus GO:0032869 IMP
    cellular response to platelet-derived growth factor stimulus GO:0036120 IMP
    TORC2 signaling GO:0038203 IBA
    TORC2 signaling GO:0038203 IMP
    positive regulation of fat cell differentiation GO:0045600 IMP
    regulation of short-term neuronal synaptic plasticity GO:0048172 IBA
    cellular response to epidermal growth factor stimulus GO:0071364 IMP
    positive regulation of protein serine/threonine kinase activity GO:0071902 IMP
    cellular response to insulin-like growth factor stimulus GO:1990314 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    growth cone GO:0030426 ISS
    presynaptic membrane GO:0042734 ISS
    perikaryon GO:0043204 ISS
    synapse GO:0045202 IBA
    postsynaptic membrane GO:0045211 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SYAP1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SYAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATAD1 84896
Affinity Capture-MS Homo sapiens
2 REEP5 7905
Proximity Label-MS Homo sapiens
3 POT1  
Two-hybrid Homo sapiens
4 RAB9A 9367
Proximity Label-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 SCYL3 57147
Affinity Capture-MS Homo sapiens
7 EBAG9 9166
Proximity Label-MS Homo sapiens
8 MIP  
Two-hybrid Homo sapiens
9 LAMP2 3920
Proximity Label-MS Homo sapiens
10 RPN2 6185
Proximity Label-MS Homo sapiens
11 GPR107 57720
Affinity Capture-MS Homo sapiens
12 TAS2R41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PSMD6 9861
Co-fractionation Homo sapiens
14 LAMTOR1 55004
Proximity Label-MS Homo sapiens
15 METTL7A 25840
Proximity Label-MS Homo sapiens
16 ZFPL1 7542
Two-hybrid Homo sapiens
17 XPO1 7514
Affinity Capture-MS Homo sapiens
18 LAMP3  
Proximity Label-MS Homo sapiens
19 KIAA1715 80856
Proximity Label-MS Homo sapiens
20 SQSTM1 8878
Proximity Label-MS Homo sapiens
21 PIN1 5300
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 LRRC59 55379
Proximity Label-MS Homo sapiens
23 PSMB7 5695
Co-fractionation Homo sapiens
24 MFN1 55669
Affinity Capture-MS Homo sapiens
25 MTCH2 23788
Proximity Label-MS Homo sapiens
26 NUBP1 4682
Affinity Capture-MS Homo sapiens
27 BCAP31 10134
Proximity Label-MS Homo sapiens
28 HSD3B7 80270
Proximity Label-MS Homo sapiens
29 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PSMB4 5692
Co-fractionation Homo sapiens
31 STIM1 6786
Proximity Label-MS Homo sapiens
32 HSD17B11 51170
Proximity Label-MS Homo sapiens
33 EMD 2010
Proximity Label-MS Homo sapiens
34 CYP1A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ETF1 2107
Co-fractionation Homo sapiens
36 PTPN1 5770
Proximity Label-MS Homo sapiens
37 BAG2 9532
Affinity Capture-MS Homo sapiens
38 STX4 6810
Proximity Label-MS Homo sapiens
39 SLC39A1 27173
Affinity Capture-MS Homo sapiens
40 TM9SF2 9375
Affinity Capture-MS Homo sapiens
41 OCIAD1 54940
Proximity Label-MS Homo sapiens
42 Ecd  
Affinity Capture-MS Mus musculus
43 THRA  
Two-hybrid Homo sapiens
44 RAB3B 5865
Proximity Label-MS Homo sapiens
45 CBX3 11335
Co-fractionation Homo sapiens
46 ERGIC2 51290
Proximity Label-MS Homo sapiens
47 MAPK6  
Affinity Capture-MS Homo sapiens
48 MED25  
Affinity Capture-MS Homo sapiens
49 FIS1 51024
Proximity Label-MS Homo sapiens
50 ADIPOQ 9370
Two-hybrid Homo sapiens
51 CDH1 999
Proximity Label-MS Homo sapiens
52 PSMA5 5686
Co-fractionation Homo sapiens
53 USP47 55031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 ATP2A1 487
Proximity Label-MS Homo sapiens
55 RNF43  
Proximity Label-MS Homo sapiens
56 OGT 8473
Reconstituted Complex Homo sapiens
57 RAB11A 8766
Proximity Label-MS Homo sapiens
58 B3GAT1  
Proximity Label-MS Homo sapiens
59 RPL35A 6165
Affinity Capture-MS Homo sapiens
60 SERPINB2 5055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CALD1 800
Cross-Linking-MS (XL-MS) Homo sapiens
62 PEX14 5195
Proximity Label-MS Homo sapiens
63 AKAP1 8165
Proximity Label-MS Homo sapiens
64 RPA4  
Proximity Label-MS Homo sapiens
65 RPN1 6184
Proximity Label-MS Homo sapiens
66 KRAS 3845
Proximity Label-MS Homo sapiens
67 SNRNP27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 TNFRSF10C  
Two-hybrid Homo sapiens
69 SSR1 6745
Proximity Label-MS Homo sapiens
70 CKAP4 10970
Proximity Label-MS Homo sapiens
71 SEC62 7095
Proximity Label-MS Homo sapiens
72 PRPS2 5634
Affinity Capture-MS Homo sapiens
73 ELOVL5 60481
Proximity Label-MS Homo sapiens
74 RAB5A 5868
Proximity Label-MS Homo sapiens
75 MIRLET7A1  
Affinity Capture-RNA Homo sapiens
76 SEC61B 10952
Proximity Label-MS Homo sapiens
77 STX6 10228
Proximity Label-MS Homo sapiens
78 CERS2 29956
Affinity Capture-MS Homo sapiens
79 DERL1 79139
Proximity Label-MS Homo sapiens
80 SLC25A46 91137
Proximity Label-MS Homo sapiens
81 RPA3 6119
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SYAP1 is involved
No pathways found





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