Gene description for SLC25A46
Gene name solute carrier family 25, member 46
Gene symbol SLC25A46
Other names/aliases -
Species Homo sapiens
 Database cross references - SLC25A46
ExoCarta ExoCarta_91137
Vesiclepedia VP_91137
Entrez Gene 91137
HGNC 25198
MIM 610826
UniProt Q96AG3  
 SLC25A46 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC25A46
Molecular Function
    protein binding GO:0005515 IPI
    protein-containing complex binding GO:0044877 IDA
Biological Process
    mitochondrial fission GO:0000266 IBA
    mitochondrial fission GO:0000266 IDA
    mitochondrial fission GO:0000266 IMP
    mitochondrial fission GO:0000266 IMP
    autophagy of mitochondrion GO:0000422 IEA
    mitochondrial transport GO:0006839 IEA
    synapse assembly GO:0007416 IEA
    respiratory chain complex IV assembly GO:0008535 IMP
    dendrite development GO:0016358 IEA
    optic nerve development GO:0021554 IEA
    cerebellar Purkinje cell differentiation GO:0021702 IEA
    myelination in peripheral nervous system GO:0022011 IEA
    locomotion involved in locomotory behavior GO:0031987 IEA
    cristae formation GO:0042407 IMP
    peripheral nervous system neuron axonogenesis GO:0048936 IEA
    establishment of localization in cell GO:0051649 IEA
    phospholipid homeostasis GO:0055091 IMP
    axon development GO:0061564 IBA
    protein-containing complex assembly GO:0065003 IMP
    mitochondrial membrane fission GO:0090149 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IBA
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial outer membrane GO:0005741 IMP
 Experiment description of studies that identified SLC25A46 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC25A46
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 KIF16B 55614
Proximity Label-MS Homo sapiens
3 AFG3L2 10939
Proximity Label-MS Homo sapiens
4 HSD17B11 51170
Two-hybrid Homo sapiens
5 C5AR1  
Affinity Capture-MS Homo sapiens
6 ANKLE2 23141
Proximity Label-MS Homo sapiens
7 DNAJC11 55735
Proximity Label-MS Homo sapiens
8 IMMT 10989
Proximity Label-MS Homo sapiens
9 SLC10A6  
Two-hybrid Homo sapiens
10 CD3D 915
Affinity Capture-MS Homo sapiens
11 PQLC1  
Two-hybrid Homo sapiens
12 SCYL1 57410
Proximity Label-MS Homo sapiens
13 GCNT1  
Affinity Capture-MS Homo sapiens
14 PDCD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MARCH2  
Proximity Label-MS Homo sapiens
16 MFN1 55669
Proximity Label-MS Homo sapiens
17 TRAK2 66008
Proximity Label-MS Homo sapiens
18 TDRKH  
Proximity Label-MS Homo sapiens
19 BSCL2  
Affinity Capture-MS Homo sapiens
20 MFAP4 4239
Affinity Capture-MS Homo sapiens
21 STIM2 57620
Proximity Label-MS Homo sapiens
22 BNIP3L  
Proximity Label-MS Homo sapiens
23 SYNE2 23224
Proximity Label-MS Homo sapiens
24 CPQ 10404
Affinity Capture-MS Homo sapiens
25 PTPN1 5770
Proximity Label-MS Homo sapiens
26 VPS13C 54832
Proximity Label-MS Homo sapiens
27 ARHGAP1 392
Proximity Label-MS Homo sapiens
28 FFAR1  
Affinity Capture-MS Homo sapiens
29 SLC22A9  
Affinity Capture-MS Homo sapiens
30 NUP160 23279
Proximity Label-MS Homo sapiens
31 REEP4  
Two-hybrid Homo sapiens
32 VAPA 9218
Proximity Label-MS Homo sapiens
33 VPS13A 23230
Proximity Label-MS Homo sapiens
34 PALD1 27143
Proximity Label-MS Homo sapiens
35 TEX264 51368
Proximity Label-MS Homo sapiens
36 FIS1 51024
Proximity Label-MS Homo sapiens
37 SLC15A1  
Affinity Capture-MS Homo sapiens
38 STBD1 8987
Proximity Label-MS Homo sapiens
39 SMCR8 140775
Proximity Label-MS Homo sapiens
40 DDX24 57062
Proximity Label-MS Homo sapiens
41 GOLGA3 2802
Proximity Label-MS Homo sapiens
42 SENP1  
Proximity Label-MS Homo sapiens
43 SMPD4 55627
Proximity Label-MS Homo sapiens
44 SRPR 6734
Proximity Label-MS Homo sapiens
45 TRABD 80305
Proximity Label-MS Homo sapiens
46 RPN1 6184
Proximity Label-MS Homo sapiens
47 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
48 OPRM1 4988
Affinity Capture-MS Homo sapiens
49 TXNL1 9352
Proximity Label-MS Homo sapiens
50 SLC22A8 9376
Affinity Capture-MS Homo sapiens
51 ABCD3 5825
Proximity Label-MS Homo sapiens
52 LSG1  
Proximity Label-MS Homo sapiens
53 ARMCX3 51566
Proximity Label-MS Homo sapiens
54 VPS13D 55187
Proximity Label-MS Homo sapiens
55 RMDN2 151393
Proximity Label-MS Homo sapiens
56 EMC3 55831
Proximity Label-MS Homo sapiens
57 PGRMC2 10424
Proximity Label-MS Homo sapiens
58 SUN2 25777
Proximity Label-MS Homo sapiens
59 EXD2  
Proximity Label-MS Homo sapiens
60 HIATL1 84641
Two-hybrid Homo sapiens
61 ERAL1  
Co-fractionation Homo sapiens
62 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
63 CCDC47 57003
Proximity Label-MS Homo sapiens
64 CCDC115 84317
Proximity Label-MS Homo sapiens
65 MTDH 92140
Proximity Label-MS Homo sapiens
66 SLC30A9 10463
Proximity Label-MS Homo sapiens
67 MAVS 57506
Proximity Label-MS Homo sapiens
68 IL13RA2 3598
Affinity Capture-MS Homo sapiens
69 ESYT2 57488
Proximity Label-MS Homo sapiens
70 FAF2 23197
Proximity Label-MS Homo sapiens
71 HK1 3098
Proximity Label-MS Homo sapiens
72 FUNDC1  
Two-hybrid Homo sapiens
73 LEPROTL1 23484
Two-hybrid Homo sapiens
74 GPR17 2840
Affinity Capture-MS Homo sapiens
75 LAMTOR1 55004
Co-fractionation Homo sapiens
76 EMC1 23065
Proximity Label-MS Homo sapiens
77 CAMLG 819
Proximity Label-MS Homo sapiens
78 LMAN1 3998
Proximity Label-MS Homo sapiens
79 NUP155 9631
Proximity Label-MS Homo sapiens
80 KIAA1715 80856
Proximity Label-MS Homo sapiens
81 LRRC59 55379
Proximity Label-MS Homo sapiens
82 EIF2AK3  
Proximity Label-MS Homo sapiens
83 VEZT 55591
Proximity Label-MS Homo sapiens
84 MTCH2 23788
Proximity Label-MS Homo sapiens
85 SCFD1 23256
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
86 SENP2 59343
Proximity Label-MS Homo sapiens
87 SLC1A5 6510
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 GCGR  
Affinity Capture-MS Homo sapiens
89 FHL3 2275
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
90 EMD 2010
Proximity Label-MS Homo sapiens
91 SLC5A6 8884
Affinity Capture-MS Homo sapiens
92 FUNDC2 65991
Proximity Label-MS Homo sapiens
93 MTFR1L 56181
Proximity Label-MS Homo sapiens
94 CHCHD3 54927
Proximity Label-MS Homo sapiens
95 LCTL  
Affinity Capture-MS Homo sapiens
96 ATPAF1  
Proximity Label-MS Homo sapiens
97 FAM73A  
Proximity Label-MS Homo sapiens
98 SNAP47 116841
Proximity Label-MS Homo sapiens
99 MAGT1 84061
Proximity Label-MS Homo sapiens
100 UBAC2 337867
Proximity Label-MS Homo sapiens
101 CDKAL1  
Proximity Label-MS Homo sapiens
102 IL2RA  
Affinity Capture-MS Homo sapiens
103 ODF4  
Two-hybrid Homo sapiens
104 TRPM7 54822
Proximity Label-MS Homo sapiens
105 OPA1 4976
Affinity Capture-MS Homo sapiens
106 PLK1 5347
Proximity Label-MS Homo sapiens
107 MIA3 375056
Proximity Label-MS Homo sapiens
108 GK  
Proximity Label-MS Homo sapiens
109 USP33  
Proximity Label-MS Homo sapiens
110 TACC1 6867
Proximity Label-MS Homo sapiens
111 JPH1 56704
Proximity Label-MS Homo sapiens
112 PREB 10113
Proximity Label-MS Homo sapiens
113 VMA21  
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
114 STX5 6811
Proximity Label-MS Homo sapiens
115 SPCS1 28972
Two-hybrid Homo sapiens
116 AHCTF1 25909
Proximity Label-MS Homo sapiens
117 RHOT2 89941
Proximity Label-MS Homo sapiens
118 GOLGB1 2804
Proximity Label-MS Homo sapiens
119 MFF 56947
Proximity Label-MS Homo sapiens
120 DNM1L 10059
Proximity Label-MS Homo sapiens
121 SLC2A9  
Affinity Capture-MS Homo sapiens
122 RMDN3 55177
Proximity Label-MS Homo sapiens
123 ACBD3 64746
Proximity Label-MS Homo sapiens
124 SNAP29 9342
Proximity Label-MS Homo sapiens
125 TEX2 55852
Proximity Label-MS Homo sapiens
126 PTGIR  
Affinity Capture-MS Homo sapiens
127 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 FBXL4 26235
Proximity Label-MS Homo sapiens
129 CISD1 55847
Proximity Label-MS Homo sapiens
130 SEC63 11231
Proximity Label-MS Homo sapiens
131 SLC22A16 85413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 TMPO 7112
Proximity Label-MS Homo sapiens
133 SLC22A6 9356
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 SV2A 9900
Affinity Capture-MS Homo sapiens
135 HCRTR2  
Affinity Capture-MS Homo sapiens
136 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 ITPR2 3709
Proximity Label-MS Homo sapiens
138 BAX 581
Proximity Label-MS Homo sapiens
139 VAPB 9217
Proximity Label-MS Homo sapiens
140 CANX 821
Proximity Label-MS Homo sapiens
141 MARCH1  
Proximity Label-MS Homo sapiens
142 LMNB1 4001
Proximity Label-MS Homo sapiens
143 SEC13 6396
Proximity Label-MS Homo sapiens
144 PRKAR2A 5576
Proximity Label-MS Homo sapiens
145 LMNB2 84823
Proximity Label-MS Homo sapiens
146 CMKLR1 1240
Affinity Capture-MS Homo sapiens
147 CRELD1 78987
Affinity Capture-MS Homo sapiens
148 BCAP31 10134
Proximity Label-MS Homo sapiens
149 STIM1 6786
Proximity Label-MS Homo sapiens
150 FKBP8 23770
Proximity Label-MS Homo sapiens
151 MYO19  
Proximity Label-MS Homo sapiens
152 SEC23A 10484
Proximity Label-MS Homo sapiens
153 AAAS 8086
Proximity Label-MS Homo sapiens
154 AQP3  
Affinity Capture-MS Homo sapiens
155 MTFR2  
Proximity Label-MS Homo sapiens
156 EHBP1 23301
Proximity Label-MS Homo sapiens
157 OCIAD1 54940
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
158 SOAT1 6646
Proximity Label-MS Homo sapiens
159 ACSL3 2181
Proximity Label-MS Homo sapiens
160 HSD17B13  
Two-hybrid Homo sapiens
161 EMC2 9694
Proximity Label-MS Homo sapiens
162 SEC16A 9919
Proximity Label-MS Homo sapiens
163 SLC10A1  
Two-hybrid Homo sapiens
164 SEC24A 10802
Proximity Label-MS Homo sapiens
165 MTFR1  
Proximity Label-MS Homo sapiens
166 STT3B 201595
Proximity Label-MS Homo sapiens
167 VRK2 7444
Proximity Label-MS Homo sapiens
168 SLC22A15  
Affinity Capture-MS Homo sapiens
169 RAB3GAP1 22930
Proximity Label-MS Homo sapiens
170 MFN2 9927
Proximity Label-MS Homo sapiens
171 DDRGK1 65992
Proximity Label-MS Homo sapiens
172 CLCC1 23155
Proximity Label-MS Homo sapiens
173 KTN1 3895
Proximity Label-MS Homo sapiens
174 VDAC1 7416
Proximity Label-MS Homo sapiens
175 CLTC 1213
Proximity Label-MS Homo sapiens
176 HAX1  
Proximity Label-MS Homo sapiens
177 TMEM209 84928
Proximity Label-MS Homo sapiens
178 SLC22A4 6583
Affinity Capture-MS Homo sapiens
179 LEMD3  
Proximity Label-MS Homo sapiens
180 MARC1  
Co-fractionation Homo sapiens
181 AKAP1 8165
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
182 SLC30A6 55676
Proximity Label-MS Homo sapiens
183 ACBD5 91452
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
184 UBE2J1 51465
Proximity Label-MS Homo sapiens
185 AVPR2  
Affinity Capture-MS Homo sapiens
186 GBAS 2631
Proximity Label-MS Homo sapiens
187 SLC37A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 SEC24B 10427
Proximity Label-MS Homo sapiens
189 LBR 3930
Proximity Label-MS Homo sapiens
190 CRLF2 64109
Affinity Capture-MS Homo sapiens
191 DDX50 79009
Proximity Label-MS Homo sapiens
192 SUN1 23353
Proximity Label-MS Homo sapiens
193 ALDH3A2 224
Proximity Label-MS Homo sapiens
194 NUP107 57122
Proximity Label-MS Homo sapiens
195 TRIM13  
Proximity Label-MS Homo sapiens
196 TACR1  
Affinity Capture-MS Homo sapiens
197 RRBP1 6238
Proximity Label-MS Homo sapiens
198 UBXN4 23190
Proximity Label-MS Homo sapiens
199 RAB3GAP2 25782
Proximity Label-MS Homo sapiens
200 SEC23IP 11196
Proximity Label-MS Homo sapiens
201 TOR1AIP2 163590
Proximity Label-MS Homo sapiens
202 AGPAT9  
Proximity Label-MS Homo sapiens
203 SYAP1 94056
Proximity Label-MS Homo sapiens
204 RTN3 10313
Proximity Label-MS Homo sapiens
205 WWOX 51741
Proximity Label-MS Homo sapiens
206 PDCL 5082
Proximity Label-MS Homo sapiens
207 LONP1 9361
Proximity Label-MS Homo sapiens
208 EMC7 56851
Proximity Label-MS Homo sapiens
209 SEC23B 10483
Proximity Label-MS Homo sapiens
210 SLC26A6 65010
Affinity Capture-MS Homo sapiens
211 TMEM214 54867
Proximity Label-MS Homo sapiens
212 EMC4 51234
Proximity Label-MS Homo sapiens
213 NBAS 51594
Proximity Label-MS Homo sapiens
214 ERLIN2 11160
Proximity Label-MS Homo sapiens
215 ITPR3 3710
Proximity Label-MS Homo sapiens
216 REEP2  
Two-hybrid Homo sapiens
217 NUP35 129401
Proximity Label-MS Homo sapiens
218 TRIP11 9321
Proximity Label-MS Homo sapiens
219 PRKAR2B 5577
Proximity Label-MS Homo sapiens
220 STOML2 30968
Proximity Label-MS Homo sapiens
221 MMGT1 93380
Proximity Label-MS Homo sapiens
222 ATAD3A 55210
Proximity Label-MS Homo sapiens
223 PDZD8 118987
Proximity Label-MS Homo sapiens
224 AUP1 550
Proximity Label-MS Homo sapiens
225 RABL3 285282
Proximity Label-MS Homo sapiens
226 USP30  
Proximity Label-MS Homo sapiens
227 NIPSNAP1 8508
Proximity Label-MS Homo sapiens
228 BCL2L13 23786
Proximity Label-MS Homo sapiens
229 HM13 81502
Proximity Label-MS Homo sapiens
230 SLC5A8 160728
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
231 INF2 64423
Proximity Label-MS Homo sapiens
232 NDC1 55706
Proximity Label-MS Homo sapiens
233 YKT6 10652
Proximity Label-MS Homo sapiens
234 MOSPD2 158747
Proximity Label-MS Homo sapiens
235 NEFL 4747
Proximity Label-MS Homo sapiens
236 P2RX2  
Affinity Capture-MS Homo sapiens
237 C9orf72  
Proximity Label-MS Homo sapiens
238 MARCH5  
Affinity Capture-MS Homo sapiens
239 CKAP4 10970
Proximity Label-MS Homo sapiens
240 VANGL1 81839
Proximity Label-MS Homo sapiens
241 WDR41  
Proximity Label-MS Homo sapiens
242 ESYT1 23344
Proximity Label-MS Homo sapiens
243 CHMP7 91782
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC25A46 is involved
No pathways found





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