Gene description for SENP2
Gene name SUMO1/sentrin/SMT3 specific peptidase 2
Gene symbol SENP2
Other names/aliases AXAM2
SMT3IP2
Species Homo sapiens
 Database cross references - SENP2
ExoCarta ExoCarta_59343
Vesiclepedia VP_59343
Entrez Gene 59343
HGNC 23116
MIM 608261
UniProt Q9HC62  
 SENP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SENP2
Molecular Function
    protein binding GO:0005515 IPI
    SUMO-specific protease activity GO:0016929 IDA
    protein domain specific binding GO:0019904 IEA
Biological Process
    spongiotrophoblast layer development GO:0060712 IEA
    negative regulation of protein binding GO:0032091 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    protein destabilization GO:0031648 IMP
    dorsal/ventral axis specification GO:0009950 IEA
    protein sumoylation GO:0016925 TAS
    cellular protein metabolic process GO:0044267 TAS
    labyrinthine layer development GO:0060711 IEA
    negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 IEA
    positive regulation of protein phosphorylation GO:0001934 IEA
    regulation of Wnt signaling pathway GO:0030111 NAS
    regulation of DNA endoreduplication GO:0032875 IEA
    protein transport GO:0015031 IEA
    positive regulation of protein ubiquitination GO:0031398 IMP
    post-translational protein modification GO:0043687 TAS
    trophoblast giant cell differentiation GO:0060707 IEA
    fat cell differentiation GO:0045444 ISS
    negative regulation of protein ubiquitination GO:0031397 IDA
    heart development GO:0007507 IEA
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of chromatin binding GO:0035562 IEA
    mRNA transport GO:0051028 IEA
    regulation of G1/S transition of mitotic cell cycle GO:2000045 IEA
    protein desumoylation GO:0016926 IMP
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    PML body GO:0016605 ISS
    nuclear membrane GO:0031965 IEA
    cytoplasmic vesicle GO:0031410 IEA
    nuclear pore GO:0005643 IDA
 Experiment description of studies that identified SENP2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SENP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AXIN1  
Invitro Homo sapiens
2 SUMO3 6612
Invivo Homo sapiens
Invitro Homo sapiens
3 NUP153 9972
Invivo Homo sapiens
Invivo Homo sapiens
4 CDK5RAP2 55755
Two-hybrid Homo sapiens
5 SUMO1 7341
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SENP2 is involved
PathwayEvidenceSource
SUMO is proteolytically processed TAS Reactome





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