Gene description for SENP2
Gene name SUMO1/sentrin/SMT3 specific peptidase 2
Gene symbol SENP2
Other names/aliases AXAM2
SMT3IP2
Species Homo sapiens
 Database cross references - SENP2
ExoCarta ExoCarta_59343
Vesiclepedia VP_59343
Entrez Gene 59343
HGNC 23116
MIM 608261
UniProt Q9HC62  
 SENP2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SENP2
Molecular Function
    protein binding GO:0005515 IPI
    deSUMOylase activity GO:0016929 IBA
    SUMO-specific endopeptidase activity GO:0070139 EXP
    SUMO-specific endopeptidase activity GO:0070139 IDA
Biological Process
    proteolysis GO:0006508 IEA
    protein transport GO:0015031 IEA
    Wnt signaling pathway GO:0016055 IEA
    protein sumoylation GO:0016925 TAS
    protein desumoylation GO:0016926 IBA
    protein desumoylation GO:0016926 IDA
    protein desumoylation GO:0016926 IMP
    regulation of Wnt signaling pathway GO:0030111 NAS
    negative regulation of protein ubiquitination GO:0031397 IDA
    positive regulation of protein ubiquitination GO:0031398 IMP
    protein destabilization GO:0031648 IMP
    fat cell differentiation GO:0045444 ISS
    mRNA transport GO:0051028 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nuclear pore GO:0005643 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    PML body GO:0016605 ISS
    nuclear membrane GO:0031965 IEA
 Experiment description of studies that identified SENP2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SENP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDCA5  
Two-hybrid Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 KPNA1 3836
Reconstituted Complex Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 GJA1 2697
Proximity Label-MS Homo sapiens
6 RBM15B  
Affinity Capture-MS Homo sapiens
7 KPNB1 3837
Reconstituted Complex Homo sapiens
8 CTDNEP1 23399
Proximity Label-MS Homo sapiens
9 SYNE4  
Two-hybrid Homo sapiens
10 NABP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 HSD17B11 51170
Proximity Label-MS Homo sapiens
12 DNAJC25 548645
Proximity Label-MS Homo sapiens
13 PTPN1 5770
Proximity Label-MS Homo sapiens
14 ARL6IP1 23204
Two-hybrid Homo sapiens
15 STX4 6810
Proximity Label-MS Homo sapiens
16 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
17 FIS1 51024
Proximity Label-MS Homo sapiens
18 RPRM  
Two-hybrid Homo sapiens
19 NUP153 9972
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
20 FZR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
21 APOC4  
Two-hybrid Homo sapiens
22 MDC1  
Affinity Capture-Western Homo sapiens
23 SSR1 6745
Proximity Label-MS Homo sapiens
24 SLC25A46 91137
Proximity Label-MS Homo sapiens
25 BCOR  
Affinity Capture-MS Homo sapiens
26 TNFRSF10D 8793
Two-hybrid Homo sapiens
27 PGK2 5232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 RAB35 11021
Proximity Label-MS Homo sapiens
29 ACSF2 80221
Two-hybrid Homo sapiens
30 APOC2 344
Two-hybrid Homo sapiens
31 LMAN1 3998
Proximity Label-MS Homo sapiens
32 NUP155 9631
Proximity Label-MS Homo sapiens
33 KIAA1715 80856
Proximity Label-MS Homo sapiens
34 PXMP2  
Proximity Label-MS Homo sapiens
35 PANX1 24145
Proximity Label-MS Homo sapiens
36 AGTRAP 57085
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 EMD 2010
Proximity Label-MS Homo sapiens
38 CXADR 1525
Proximity Label-MS Homo sapiens
39 FUNDC1  
Two-hybrid Homo sapiens
40 RAB4A 5867
Proximity Label-MS Homo sapiens
41 TPD52 7163
Two-hybrid Homo sapiens
42 OGT 8473
Reconstituted Complex Homo sapiens
43 PNMA2  
Affinity Capture-MS Homo sapiens
44 S100B 6285
Affinity Capture-MS Homo sapiens
45 RPN1 6184
Proximity Label-MS Homo sapiens
46 PML 5371
Affinity Capture-MS Homo sapiens
47 Ube2i  
Affinity Capture-MS Mus musculus
48 ELOVL5 60481
Proximity Label-MS Homo sapiens
49 USP28 57646
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 DAXX  
Biochemical Activity Homo sapiens
51 REEP5 7905
Proximity Label-MS Homo sapiens
52 RPN2 6185
Proximity Label-MS Homo sapiens
53 Nup98  
Affinity Capture-MS Mus musculus
54 CIAO1 9391
Affinity Capture-MS Homo sapiens
55 LRRC59 55379
Proximity Label-MS Homo sapiens
56 LMNB1 4001
Proximity Label-MS Homo sapiens
57 Dennd6a  
Affinity Capture-MS Mus musculus
58 ARMC12  
Two-hybrid Homo sapiens
59 BCAP31 10134
Proximity Label-MS Homo sapiens
60 HSD3B7 80270
Proximity Label-MS Homo sapiens
61 STIM1 6786
Proximity Label-MS Homo sapiens
62 NUP43 348995
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
63 NACC1 112939
Biochemical Activity Homo sapiens
64 SUMO2 6613
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
65 CDK5RAP2 55755
Two-hybrid Homo sapiens
66 MAPRE3  
Proximity Label-MS Homo sapiens
67 CCDC155  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 FAM134C 162427
Two-hybrid Homo sapiens
69 Nup107  
Affinity Capture-MS Mus musculus
70 ATP2A1 487
Proximity Label-MS Homo sapiens
71 RAB9A 9367
Proximity Label-MS Homo sapiens
72 NEDD4L 23327
Reconstituted Complex Homo sapiens
73 SUMO1 7341
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
74 TMEM239  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
75 RNF43  
Proximity Label-MS Homo sapiens
76 SMN1 6606
Affinity Capture-Western Homo sapiens
77 SDR16C5  
Two-hybrid Homo sapiens
78 IKBKG 8517
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
79 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
80 NUP35 129401
Proximity Label-MS Homo sapiens
81 HNRNPK 3190
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 DNAJC14  
Proximity Label-MS Homo sapiens
83 ERGIC2 51290
Proximity Label-MS Homo sapiens
84 NUP107 57122
Affinity Capture-MS Homo sapiens
85 SEC61B 10952
Proximity Label-MS Homo sapiens
86 SEC62 7095
Proximity Label-MS Homo sapiens
87 B3GAT1  
Proximity Label-MS Homo sapiens
88 RAB11A 8766
Proximity Label-MS Homo sapiens
89 TRIM63  
Biochemical Activity Homo sapiens
90 Ranbp2  
Affinity Capture-MS Mus musculus
91 HIPK2 28996
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
92 DNAJC1 64215
Proximity Label-MS Homo sapiens
93 SUMO3 6612
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
94 MYC  
Biochemical Activity Homo sapiens
95 CKAP4 10970
Proximity Label-MS Homo sapiens
96 RANGAP1 5905
Biochemical Activity Homo sapiens
97 DERL1 79139
Proximity Label-MS Homo sapiens
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