Gene description for APOC2
Gene name apolipoprotein C-II
Gene symbol APOC2
Other names/aliases APO-CII
Species Homo sapiens
 Database cross references - APOC2
ExoCarta ExoCarta_344
Entrez Gene 344
HGNC 609
MIM 608083
UniProt P02655  
 APOC2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for APOC2
Molecular Function
    phospholipase binding GO:0043274 IPI
    lipid binding GO:0008289 IDA
    phospholipase activator activity GO:0016004 IDA
    lipoprotein lipase activator activity GO:0060230 IDA
    protein homodimerization activity GO:0042803 IMP
    lipase inhibitor activity GO:0055102 IDA
Biological Process
    negative regulation of catalytic activity GO:0043086 IDA
    chylomicron remnant clearance GO:0034382 IDA
    negative regulation of cholesterol transport GO:0032375 IMP
    negative regulation of very-low-density lipoprotein particle clearance GO:0010916 IDA
    positive regulation of phospholipid catabolic process GO:0060697 IDA
    triglyceride-rich lipoprotein particle remodeling GO:0034370 TAS
    positive regulation of fatty acid biosynthetic process GO:0045723 IDA
    retinoid metabolic process GO:0001523 TAS
    triglyceride homeostasis GO:0070328 IMP
    reverse cholesterol transport GO:0043691 IC
    chylomicron remodeling GO:0034371 IC
    cholesterol efflux GO:0033344 IDA
    phospholipid efflux GO:0033700 IDA
    positive regulation of very-low-density lipoprotein particle remodeling GO:0010902 IC
    cholesterol homeostasis GO:0042632 IC
    high-density lipoprotein particle clearance GO:0034384 IMP
    small molecule metabolic process GO:0044281 TAS
    positive regulation of lipoprotein lipase activity GO:0051006 IDA
    negative regulation of lipid metabolic process GO:0045833 IDA
    positive regulation of phospholipase activity GO:0010518 IDA
    positive regulation of triglyceride catabolic process GO:0010898 IDA
    lipoprotein metabolic process GO:0042157 TAS
    very-low-density lipoprotein particle remodeling GO:0034372 TAS
    negative regulation of receptor-mediated endocytosis GO:0048261 IDA
    phototransduction, visible light GO:0007603 TAS
    lipid catabolic process GO:0016042 IEA
Subcellular Localization
    chylomicron GO:0042627 IDA
    intermediate-density lipoprotein particle GO:0034363 IDA
    extracellular space GO:0005615 IDA
    early endosome GO:0005769 TAS
    spherical high-density lipoprotein particle GO:0034366 IDA
    extracellular exosome GO:0070062 IDA
    very-low-density lipoprotein particle GO:0034361 IDA
    extracellular region GO:0005576 TAS
    low-density lipoprotein particle GO:0034362 IDA
 Experiment description of studies that identified APOC2 in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for APOC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LPL 4023
Invitro Homo sapiens
2 LPL 280843
Reconstituted Complex Bos taurus
View the network image/svg+xml

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