Gene description for APOC2
Gene name apolipoprotein C-II
Gene symbol APOC2
Other names/aliases APO-CII
APOC-II
Species Homo sapiens
 Database cross references - APOC2
ExoCarta ExoCarta_344
Vesiclepedia VP_344
Entrez Gene 344
HGNC 609
MIM 608083
UniProt P02655  
 APOC2 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for APOC2
Molecular Function
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IDA
    phospholipase activator activity GO:0016004 IBA
    phospholipase activator activity GO:0016004 IDA
    identical protein binding GO:0042802 IPI
    phospholipase binding GO:0043274 IBA
    phospholipase binding GO:0043274 IPI
    lipase inhibitor activity GO:0055102 IDA
    lipoprotein lipase activator activity GO:0060230 IDA
    molecular function activator activity GO:0140677 EXP
Biological Process
    positive regulation of phospholipase activity GO:0010518 IDA
    positive regulation of triglyceride catabolic process GO:0010898 IDA
    positive regulation of very-low-density lipoprotein particle remodeling GO:0010902 IC
    negative regulation of very-low-density lipoprotein particle clearance GO:0010916 IDA
    lipid catabolic process GO:0016042 IEA
    negative regulation of cholesterol transport GO:0032375 IMP
    cholesterol efflux GO:0033344 IDA
    phospholipid efflux GO:0033700 IDA
    triglyceride-rich lipoprotein particle remodeling GO:0034370 TAS
    chylomicron remodeling GO:0034371 IC
    very-low-density lipoprotein particle remodeling GO:0034372 TAS
    chylomicron remnant clearance GO:0034382 IBA
    chylomicron remnant clearance GO:0034382 IDA
    high-density lipoprotein particle clearance GO:0034384 IBA
    high-density lipoprotein particle clearance GO:0034384 IMP
    lipoprotein catabolic process GO:0042159 IBA
    cholesterol homeostasis GO:0042632 IC
    reverse cholesterol transport GO:0043691 IC
    positive regulation of fatty acid biosynthetic process GO:0045723 IDA
    negative regulation of lipid metabolic process GO:0045833 IDA
    negative regulation of receptor-mediated endocytosis GO:0048261 IDA
    positive regulation of lipoprotein lipase activity GO:0051006 IDA
    positive regulation of phospholipid catabolic process GO:0060697 IDA
    triglyceride homeostasis GO:0070328 IMP
Subcellular Localization
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    early endosome GO:0005769 TAS
    very-low-density lipoprotein particle GO:0034361 IBA
    very-low-density lipoprotein particle GO:0034361 IDA
    low-density lipoprotein particle GO:0034362 IBA
    low-density lipoprotein particle GO:0034362 IDA
    intermediate-density lipoprotein particle GO:0034363 IBA
    intermediate-density lipoprotein particle GO:0034363 IDA
    spherical high-density lipoprotein particle GO:0034366 IBA
    spherical high-density lipoprotein particle GO:0034366 IDA
    chylomicron GO:0042627 IBA
    chylomicron GO:0042627 IDA
 Experiment description of studies that identified APOC2 in sEVs
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for APOC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFI27  
Two-hybrid Homo sapiens
2 TMEM14B  
Two-hybrid Homo sapiens
3 APOA2 336
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
4 GAD2  
Two-hybrid Homo sapiens
5 MINOS1  
Two-hybrid Homo sapiens
6 RNF166  
Affinity Capture-MS Homo sapiens
7 LPL 280843
Reconstituted Complex Bos taurus
8 NFU1 27247
Two-hybrid Homo sapiens
9 SYT16  
Two-hybrid Homo sapiens
10 THBD 7056
Two-hybrid Homo sapiens
11 DSCR4  
Affinity Capture-MS Homo sapiens
12 UBQLN2 29978
Two-hybrid Homo sapiens
13 ALB 213
Affinity Capture-MS Homo sapiens
14 SENP2 59343
Two-hybrid Homo sapiens
15 APOE 348
Affinity Capture-MS Homo sapiens
16 APOD 347
Cross-Linking-MS (XL-MS) Homo sapiens
17 XAGE3  
Affinity Capture-MS Homo sapiens
18 SNAP47 116841
Two-hybrid Homo sapiens
19 DIABLO 56616
Two-hybrid Homo sapiens
20 MED21  
Affinity Capture-MS Homo sapiens
21 SOAT1 6646
Affinity Capture-MS Homo sapiens
22 GSDMA 284110
Two-hybrid Homo sapiens
23 APOL2 23780
Two-hybrid Homo sapiens
24 TBC1D20  
Two-hybrid Homo sapiens
25 TPRG1  
Two-hybrid Homo sapiens
26 BCL2L2 599
Two-hybrid Homo sapiens
27 CRYAB 1410
Reconstituted Complex Homo sapiens
28 C19orf70  
Two-hybrid Homo sapiens
29 TIMMDC1  
Two-hybrid Homo sapiens
30 PORCN 64840
Two-hybrid Homo sapiens
31 CROCCP2  
Affinity Capture-MS Homo sapiens
32 C2orf47  
Two-hybrid Homo sapiens
33 RSAD2  
Two-hybrid Homo sapiens
34 UBQLN1 29979
Two-hybrid Homo sapiens
35 TTPA  
Two-hybrid Homo sapiens
36 APOA1 335
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
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