Gene description for LPL
Gene name lipoprotein lipase
Gene symbol LPL
Other names/aliases -
Species Bos taurus
 Database cross references - LPL
ExoCarta ExoCarta_280843
Entrez Gene 280843
UniProt P11151  
 LPL identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for LPL
Molecular Function
    heparin binding GO:0008201 IEA
    protein binding GO:0005515 IPI
    triglyceride lipase activity GO:0004806 IDA
    apolipoprotein binding GO:0034185 IPI
    lipoprotein lipase activity GO:0004465 IDA
    phospholipase activity GO:0004620 IDA
    receptor binding GO:0005102 IEA
Biological Process
    positive regulation of macrophage derived foam cell differentiation GO:0010744 IEA
    phospholipid metabolic process GO:0006644 IDA
    fatty acid biosynthetic process GO:0006633 IDA
    triglyceride metabolic process GO:0006641 IDA
    positive regulation of sequestering of triglyceride GO:0010890 IEA
    triglyceride catabolic process GO:0019433 IDA
    very-low-density lipoprotein particle remodeling GO:0034372 IDA
    positive regulation of cholesterol storage GO:0010886 IEA
    triglyceride homeostasis GO:0070328 IEA
Subcellular Localization
    cell surface GO:0009986 IEA
    very-low-density lipoprotein particle GO:0034361 IEA
    anchored component of membrane GO:0031225 IEA
    extracellular exosome GO:0070062 IEA
    plasma membrane GO:0005886 IEA
    chylomicron GO:0042627 IEA
 Experiment description of studies that identified LPL in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LPL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APOC2 344
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which LPL is involved
Chylomicron-mediated lipid transport IEA Reactome
Retinoid metabolism and transport IEA Reactome

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