Gene description for BCL2L2
Gene name
BCL2-like 2
Gene symbol
BCL2L2
Other names/aliases
BCL-W BCL2-L-2 BCLW PPP1R51
Species
Homo sapiens
Database cross references - BCL2L2
ExoCarta
ExoCarta_599
Entrez Gene
599
HGNC
995
MIM
601931
UniProt
Q92843
BCL2L2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells
26054723
Hepatocytes
26054723
Gene ontology annotations for BCL2L2
Experiment description of studies that identified BCL2L2 in exosomes
1
Experiment ID
235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule
mRNA
Identification method
RNA Sequencing
PubMed ID
26054723
Organism
Homo sapiens
Experiment description
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors
He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name
Carcinogenesis
Publication year
2015
Sample
Hepatocellular carcinoma cells
Sample name
HKCI-8
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.19 g/mL
Molecules identified in the study
Protein RNA
Methods used in the study
Western blotting Mass spectrometry RT-PCR RNA Sequencing
2
Experiment ID
237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘
EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule
mRNA
Identification method
RNA Sequencing
PubMed ID
26054723
Organism
Homo sapiens
Experiment description
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors
He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name
Carcinogenesis
Publication year
2015
Sample
Hepatocytes
Sample name
MIHA
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.19 g/mL
Molecules identified in the study
Protein RNA
Methods used in the study
Western blotting Mass spectrometry RNA Sequencing
Protein-protein interactions for BCL2L2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
BAD
Reconstituted Complex
Homo sapiens
Protein-peptide
Homo sapiens
Affinity Capture-Western
Homo sapiens
Two-hybrid
Homo sapiens
2
PPP1CA
5499
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
3
PMAIP1
Protein-peptide
Homo sapiens
4
BMF
Affinity Capture-Western
Homo sapiens
5
BID
Protein-peptide
Homo sapiens
6
BCL2L11
Two-hybrid
Homo sapiens
7
Bcl2l11
Protein-peptide
Mus musculus
8
HRK
Protein-peptide
Homo sapiens
View the network
image/svg+xml
Pathways in which BCL2L2 is involved
No pathways found