Gene description for APOL2
Gene name apolipoprotein L, 2
Gene symbol APOL2
Other names/aliases APOL-II
APOL3
Species Homo sapiens
 Database cross references - APOL2
ExoCarta ExoCarta_23780
Vesiclepedia VP_23780
Entrez Gene 23780
HGNC 619
MIM 607252
UniProt Q9BQE5  
 APOL2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for APOL2
Molecular Function
    signaling receptor binding GO:0005102 NAS
    protein binding GO:0005515 IPI
    high-density lipoprotein particle binding GO:0008035 NAS
    lipid binding GO:0008289 IBA
    lipid binding GO:0008289 NAS
Biological Process
    lipid metabolic process GO:0006629 NAS
    lipid transport GO:0006869 NAS
    acute-phase response GO:0006953 NAS
    cholesterol metabolic process GO:0008203 NAS
    lipoprotein metabolic process GO:0042157 IEA
    maternal process involved in female pregnancy GO:0060135 NAS
Subcellular Localization
    extracellular region GO:0005576 IEA
    endoplasmic reticulum membrane GO:0005789 NAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified APOL2 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for APOL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 NCBP1 4686
Affinity Capture-MS Homo sapiens
4 DPP9 91039
Affinity Capture-MS Homo sapiens
5 MTCH1 23787
Proximity Label-MS Homo sapiens
6 UBL4A 8266
Affinity Capture-MS Homo sapiens
7 RXFP1  
Affinity Capture-MS Homo sapiens
8 MARCKS 4082
Proximity Label-MS Homo sapiens
9 EMP1  
Two-hybrid Homo sapiens
10 AIG1  
Two-hybrid Homo sapiens
11 BPNT1 10380
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MARCH3 115123
Two-hybrid Homo sapiens
13 STX1A 6804
Two-hybrid Homo sapiens
14 APBB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 MGST3 4259
Two-hybrid Homo sapiens
16 ERAP1 51752
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 VAPB 9217
Affinity Capture-MS Homo sapiens
18 GNAZ 2781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 EBAG9 9166
Two-hybrid Homo sapiens
20 APOC2 344
Two-hybrid Homo sapiens
21 TMEM63B 55362
Affinity Capture-MS Homo sapiens
22 BSG 682
Affinity Capture-MS Homo sapiens
23 MTCH2 23788
Proximity Label-MS Homo sapiens
24 MAPK3 5595
Affinity Capture-MS Homo sapiens
25 NPTN 27020
Affinity Capture-MS Homo sapiens
26 ALDH3B1 221
Affinity Capture-MS Homo sapiens
27 TMEM45B 120224
Two-hybrid Homo sapiens
28 RPN1 6184
Proximity Label-MS Homo sapiens
29 FAM127A  
Affinity Capture-MS Homo sapiens
30 ITGB2 3689
Two-hybrid Homo sapiens
31 C17orf62 79415
Two-hybrid Homo sapiens
32 MFF 56947
Two-hybrid Homo sapiens
33 GJB5  
Two-hybrid Homo sapiens
34 SFXN5  
Two-hybrid Homo sapiens
35 CHRND  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 TMEM60  
Two-hybrid Homo sapiens
37 PSG9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 C7orf34  
Affinity Capture-MS Homo sapiens
39 HTR3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 KCNA1  
Two-hybrid Homo sapiens
41 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 HADHB 3032
Co-fractionation Homo sapiens
43 RPN2 6185
Proximity Label-MS Homo sapiens
44 YIPF6 286451
Two-hybrid Homo sapiens
45 PANX1 24145
Two-hybrid Homo sapiens
46 TMED8 283578
Two-hybrid Homo sapiens
47 PTH2R  
Affinity Capture-MS Homo sapiens
48 MEX3A  
Affinity Capture-RNA Homo sapiens
49 PRMT8  
Affinity Capture-MS Homo sapiens
50 POLK  
Affinity Capture-MS Homo sapiens
51 CERK 64781
Affinity Capture-MS Homo sapiens
52 HSD3B7 80270
Proximity Label-MS Homo sapiens
53 GPR12  
Affinity Capture-MS Homo sapiens
54 TMEM139  
Two-hybrid Homo sapiens
55 BCAP31 10134
Proximity Label-MS Homo sapiens
56 TMEM52B 120939
Two-hybrid Homo sapiens
57 FAM209A 200232
Two-hybrid Homo sapiens
58 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
59 WRB 7485
Two-hybrid Homo sapiens
60 ATP2A1 487
Proximity Label-MS Homo sapiens
61 GBP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 PSCA 8000
Two-hybrid Homo sapiens
63 SIT1 27240
Two-hybrid Homo sapiens
64 AKAP1 8165
Proximity Label-MS Homo sapiens
65 SOD1 6647
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 STX2 2054
Two-hybrid Homo sapiens
67 GBAS 2631
Co-fractionation Homo sapiens
68 SLC2A12 154091
Affinity Capture-MS Homo sapiens
69 DPP6  
Affinity Capture-MS Homo sapiens
70 PRKY  
Affinity Capture-MS Homo sapiens
71 SLC26A6 65010
Two-hybrid Homo sapiens
72 Id2  
Affinity Capture-MS Mus musculus
73 APOC4  
Two-hybrid Homo sapiens
74 ERGIC1 57222
Proximity Label-MS Homo sapiens
75 Tuba3a 22144
Affinity Capture-MS Mus musculus
76 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 BSND  
Two-hybrid Homo sapiens
78 SEC61B 10952
Proximity Label-MS Homo sapiens
79 EID3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CISD2 493856
Two-hybrid Homo sapiens
81 DUSP22  
Affinity Capture-MS Homo sapiens
82 RAB5C 5878
Proximity Label-MS Homo sapiens
83 MAST3  
Affinity Capture-MS Homo sapiens
84 CHRNB1  
Affinity Capture-MS Homo sapiens
85 MRPS9 64965
Affinity Capture-MS Homo sapiens
86 CHRNA3 1136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which APOL2 is involved
No pathways found





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