Gene description for YIPF6
Gene name Yip1 domain family, member 6
Gene symbol YIPF6
Other names/aliases FinGER6
Species Homo sapiens
 Database cross references - YIPF6
ExoCarta ExoCarta_286451
Vesiclepedia VP_286451
Entrez Gene 286451
HGNC 28304
UniProt Q96EC8  
 YIPF6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for YIPF6
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IEA
Biological Process
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IEA
    intestinal epithelial cell development GO:0060576 IEA
Subcellular Localization
    Golgi trans cisterna GO:0000138 IDA
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum GO:0005783 IDA
    Golgi medial cisterna GO:0005797 IDA
    cis-Golgi network GO:0005801 IEA
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 IDA
    COPII-coated ER to Golgi transport vesicle GO:0030134 IEA
 Experiment description of studies that identified YIPF6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for YIPF6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 SLC30A8  
Two-hybrid Homo sapiens
3 SLC10A6  
Two-hybrid Homo sapiens
4 SLC10A1  
Two-hybrid Homo sapiens
5 BSCL2  
Affinity Capture-MS Homo sapiens
6 MFSD5  
Two-hybrid Homo sapiens
7 HSD17B11 51170
Two-hybrid Homo sapiens
8 CYSLTR2  
Two-hybrid Homo sapiens
9 SLC7A14  
Affinity Capture-MS Homo sapiens
10 CD79A  
Two-hybrid Homo sapiens
11 SLC30A4 7782
Two-hybrid Homo sapiens
12 FFAR1  
Affinity Capture-MS Homo sapiens
13 MS4A3  
Two-hybrid Homo sapiens
14 TMEM130  
Two-hybrid Homo sapiens
15 MMD  
Two-hybrid Homo sapiens
16 GPRC5B 51704
Affinity Capture-MS Homo sapiens
17 HIATL1 84641
Two-hybrid Homo sapiens
18 CCDC47 57003
Affinity Capture-MS Homo sapiens
19 NDUFAF1  
Two-hybrid Homo sapiens
20 F2RL1  
Two-hybrid Homo sapiens
21 GPX8 493869
Two-hybrid Homo sapiens
22 CLN8 2055
Two-hybrid Homo sapiens
23 SLC12A7 10723
Two-hybrid Homo sapiens
24 SSMEM1  
Two-hybrid Homo sapiens
25 PDZK1IP1 10158
Two-hybrid Homo sapiens
26 TMEM106C 79022
Two-hybrid Homo sapiens
27 UNK  
Affinity Capture-RNA Homo sapiens
28 FCER1G 2207
Two-hybrid Homo sapiens
29 EFNA5  
Two-hybrid Homo sapiens
30 TMEM14B  
Two-hybrid Homo sapiens
31 STOM 2040
Two-hybrid Homo sapiens
32 GPR35  
Affinity Capture-MS Homo sapiens
33 LRRC25  
Two-hybrid Homo sapiens
34 RAET1L  
Two-hybrid Homo sapiens
35 SLC39A2  
Two-hybrid Homo sapiens
36 APOL2 23780
Two-hybrid Homo sapiens
37 TUSC5  
Two-hybrid Homo sapiens
38 TMEM71  
Two-hybrid Homo sapiens
39 ODF4  
Two-hybrid Homo sapiens
40 RHCG 51458
Two-hybrid Homo sapiens
41 IL10RA  
Two-hybrid Homo sapiens
42 IL27RA 9466
Two-hybrid Homo sapiens
43 GJB1 2705
Two-hybrid Homo sapiens
44 KCNJ6  
Two-hybrid Homo sapiens
45 ARL13B 200894
Two-hybrid Homo sapiens
46 LRRC3B  
Two-hybrid Homo sapiens
47 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 GJA8  
Two-hybrid Homo sapiens
49 AQP2 359
Two-hybrid Homo sapiens
50 GJA5 2702
Two-hybrid Homo sapiens
51 FFAR2  
Two-hybrid Homo sapiens
52 MTIF3  
Two-hybrid Homo sapiens
53 CRB3 92359
Two-hybrid Homo sapiens
54 ERGIC3 51614
Two-hybrid Homo sapiens
55 P2RY2 5029
Affinity Capture-MS Homo sapiens
56 GPR101  
Two-hybrid Homo sapiens
57 YIPF2 78992
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 LRRC4C  
Two-hybrid Homo sapiens
59 TMEM11 8834
Two-hybrid Homo sapiens
60 SLC39A1 27173
Two-hybrid Homo sapiens
61 CREB3L1  
Two-hybrid Homo sapiens
62 TCTA  
Two-hybrid Homo sapiens
63 GPR152  
Two-hybrid Homo sapiens
64 FAM209A 200232
Two-hybrid Homo sapiens
65 ATP6V0E1  
Two-hybrid Homo sapiens
66 GPR42  
Two-hybrid Homo sapiens
67 FAM134C 162427
Two-hybrid Homo sapiens
68 TMEM237 65062
Two-hybrid Homo sapiens
69 CPLX4  
Two-hybrid Homo sapiens
70 PSCA 8000
Two-hybrid Homo sapiens
71 CISD2 493856
Two-hybrid Homo sapiens
72 LYVE1  
Two-hybrid Homo sapiens
73 RNF185  
Two-hybrid Homo sapiens
74 SLC17A8  
Two-hybrid Homo sapiens
75 TRHR  
Two-hybrid Homo sapiens
76 SLC9A6 10479
Affinity Capture-MS Homo sapiens
77 LPAR1 1902
Affinity Capture-MS Homo sapiens
78 TMX2 51075
Two-hybrid Homo sapiens
79 YIPF1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CXorf66  
Two-hybrid Homo sapiens
81 TP53 7157
Affinity Capture-MS Homo sapiens
82 ULBP2 80328
Two-hybrid Homo sapiens
83 TVP23B  
Two-hybrid Homo sapiens
84 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
85 EBP  
Two-hybrid Homo sapiens
86 KCNE3  
Affinity Capture-MS Homo sapiens
87 SLC38A7 55238
Two-hybrid Homo sapiens
88 THAP4 51078
Two-hybrid Homo sapiens
89 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 LY6G6C  
Two-hybrid Homo sapiens
91 LPAR2 9170
Affinity Capture-MS Homo sapiens
92 TPST2 8459
Affinity Capture-MS Homo sapiens
93 KCNK5  
Two-hybrid Homo sapiens
94 VIPR1  
Affinity Capture-MS Homo sapiens
95 ADGRE5 976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 TMEM31  
Two-hybrid Homo sapiens
97 CNR2  
Two-hybrid Homo sapiens
98 SLC1A1 6505
Affinity Capture-MS Homo sapiens
99 ELOVL4  
Two-hybrid Homo sapiens
100 IL1RL1 9173
Two-hybrid Homo sapiens
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