Gene description for YIPF2
Gene name Yip1 domain family, member 2
Gene symbol YIPF2
Other names/aliases FinGER2
Species Homo sapiens
 Database cross references - YIPF2
ExoCarta ExoCarta_78992
Vesiclepedia VP_78992
Entrez Gene 78992
HGNC 28476
UniProt Q9BWQ6  
 YIPF2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for YIPF2
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IEA
Biological Process
    vesicle-mediated transport GO:0016192 IEA
Subcellular Localization
    Golgi trans cisterna GO:0000138 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi medial cisterna GO:0005797 IDA
    trans-Golgi network GO:0005802 IDA
    transport vesicle GO:0030133 IDA
    late endosome membrane GO:0031902 IEA
 Experiment description of studies that identified YIPF2 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for YIPF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 FAM159A  
Two-hybrid Homo sapiens
3 TOMM34 10953
Affinity Capture-MS Homo sapiens
4 SLC30A2  
Two-hybrid Homo sapiens
5 SLC10A6  
Two-hybrid Homo sapiens
6 LEPROTL1 23484
Two-hybrid Homo sapiens
7 TMEM143  
Two-hybrid Homo sapiens
8 FFAR2  
Two-hybrid Homo sapiens
9 YIPF6 286451
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 VIM 7431
Affinity Capture-MS Homo sapiens
11 ACTA2 59
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 APOB 338
Affinity Capture-MS Homo sapiens
13 TVP23B  
Two-hybrid Homo sapiens
14 ERGIC3 51614
Two-hybrid Homo sapiens
15 TMEM14B  
Two-hybrid Homo sapiens
16 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
17 HSD17B13  
Two-hybrid Homo sapiens
18 SLC39A3  
Two-hybrid Homo sapiens
19 TMEM173  
Two-hybrid Homo sapiens
20 SYPL2  
Two-hybrid Homo sapiens
21 GPR42  
Two-hybrid Homo sapiens
22 RNF5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 CREB3  
Two-hybrid Homo sapiens
24 SPCS1 28972
Two-hybrid Homo sapiens
25 RNF185  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 FATE1  
Two-hybrid Homo sapiens
27 PGRMC2 10424
Two-hybrid Homo sapiens
28 HIATL1 84641
Two-hybrid Homo sapiens
29 TMX2 51075
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which YIPF2 is involved
No pathways found





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