Gene description for TMX2
Gene name thioredoxin-related transmembrane protein 2
Gene symbol TMX2
Other names/aliases CGI-31
PDIA12
PIG26
TXNDC14
Species Homo sapiens
 Database cross references - TMX2
ExoCarta ExoCarta_51075
Vesiclepedia VP_51075
Entrez Gene 51075
HGNC 30739
UniProt Q9Y320  
 TMX2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
 Gene ontology annotations for TMX2
Molecular Function
    protein binding GO:0005515 IPI
    disulfide oxidoreductase activity GO:0015036 IBA
    disulfide oxidoreductase activity GO:0015036 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    brain development GO:0007420 IBA
    brain development GO:0007420 IMP
Subcellular Localization
    mitochondrion GO:0005739 IMP
    endoplasmic reticulum membrane GO:0005789 IDA
    mitochondrial membrane GO:0031966 IEA
    membrane-bounded organelle GO:0043227 IBA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IDA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 IDA
 Experiment description of studies that identified TMX2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for TMX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C2CD2L 9854
Two-hybrid Homo sapiens
2 HSD17B11 51170
Two-hybrid Homo sapiens
3 TSNARE1  
Two-hybrid Homo sapiens
4 AGPAT5 55326
Two-hybrid Homo sapiens
5 SLC35A1 10559
Two-hybrid Homo sapiens
6 STATH  
Two-hybrid Homo sapiens
7 CHRNA4  
Affinity Capture-MS Homo sapiens
8 RXFP1  
Affinity Capture-MS Homo sapiens
9 VAPA 9218
Two-hybrid Homo sapiens
10 PAEP  
Two-hybrid Homo sapiens
11 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 FA2H  
Two-hybrid Homo sapiens
13 THBD 7056
Two-hybrid Homo sapiens
14 RPA2 6118
Proximity Label-MS Homo sapiens
15 SMIM1 388588
Two-hybrid Homo sapiens
16 HTATIP2 10553
Two-hybrid Homo sapiens
17 PTPN9 5780
Two-hybrid Homo sapiens
18 AIG1  
Two-hybrid Homo sapiens
19 MARCH3 115123
Affinity Capture-MS Homo sapiens
20 KCNA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CYP19A1  
Affinity Capture-MS Homo sapiens
22 COX20  
Two-hybrid Homo sapiens
23 GJB2  
Two-hybrid Homo sapiens
24 REEP4  
Two-hybrid Homo sapiens
25 BNIP1 662
Two-hybrid Homo sapiens
26 TMEM65 157378
Two-hybrid Homo sapiens
27 TMEM222 84065
Two-hybrid Homo sapiens
28 C4orf32  
Affinity Capture-MS Homo sapiens
29 COPB2 9276
Affinity Capture-MS Homo sapiens
30 GINM1 116254
Affinity Capture-MS Homo sapiens
31 GIMAP1  
Two-hybrid Homo sapiens
32 TM9SF4 9777
Co-fractionation Homo sapiens
33 TMBIM6 7009
Two-hybrid Homo sapiens
34 SELK  
Two-hybrid Homo sapiens
35 GIMAP5  
Two-hybrid Homo sapiens
36 TMEM201 199953
Two-hybrid Homo sapiens
37 C10orf35  
Two-hybrid Homo sapiens
38 LRAT  
Two-hybrid Homo sapiens
39 TMEM115 11070
Two-hybrid Homo sapiens
40 COL8A2 1296
Two-hybrid Homo sapiens
41 C3orf52  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
42 TMEM97 27346
Two-hybrid Homo sapiens
43 HIATL1 84641
Two-hybrid Homo sapiens
44 TMEM140  
Two-hybrid Homo sapiens
45 ORMDL2 29095
Two-hybrid Homo sapiens
46 F2RL1  
Two-hybrid Homo sapiens
47 SMAGP  
Two-hybrid Homo sapiens
48 BET1 10282
Two-hybrid Homo sapiens
49 IL17RA 23765
Affinity Capture-MS Homo sapiens
50 TMEM63C  
Affinity Capture-MS Homo sapiens
51 SERBP1 26135
Affinity Capture-MS Homo sapiens
52 PTH1R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 ITGAM 3684
Two-hybrid Homo sapiens
54 LEPROTL1 23484
Two-hybrid Homo sapiens
55 SACM1L 22908
Two-hybrid Homo sapiens
56 TMEM254  
Two-hybrid Homo sapiens
57 INSIG2  
Two-hybrid Homo sapiens
58 DGAT2L6  
Two-hybrid Homo sapiens
59 TMEM120A 83862
Two-hybrid Homo sapiens
60 HTR3C  
Affinity Capture-MS Homo sapiens
61 TREX1  
Two-hybrid Homo sapiens
62 TMEM14B  
Two-hybrid Homo sapiens
63 FAM3C 10447
Two-hybrid Homo sapiens
64 EMD 2010
Two-hybrid Homo sapiens
65 NSG1  
Two-hybrid Homo sapiens
66 IGFBP5 3488
Two-hybrid Homo sapiens
67 SLC29A2 3177
Two-hybrid Homo sapiens
68 FUNDC2 65991
Two-hybrid Homo sapiens
69 EMP3 2014
Two-hybrid Homo sapiens
70 SFXN3 81855
Two-hybrid Homo sapiens
71 LEPROT 54741
Two-hybrid Homo sapiens
72 CYP4F2  
Two-hybrid Homo sapiens
73 TMEM189-UBE2V1 387522
Two-hybrid Homo sapiens
74 TSPAN2 10100
Two-hybrid Homo sapiens
75 PRB1  
Two-hybrid Homo sapiens
76 ARV1  
Two-hybrid Homo sapiens
77 CYB5A 1528
Co-fractionation Homo sapiens
78 YIF1A 10897
Two-hybrid Homo sapiens
79 C16orf58 64755
Two-hybrid Homo sapiens
80 TMEM50B 757
Two-hybrid Homo sapiens
81 TRIM21 6737
Affinity Capture-MS Homo sapiens
82 UNC93A  
Two-hybrid Homo sapiens
83 SLC4A8 9498
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 CD81 975
Two-hybrid Homo sapiens
85 VAMP1 6843
Two-hybrid Homo sapiens
86 FXYD6-FXYD2  
Two-hybrid Homo sapiens
87 UBE2J1 51465
Two-hybrid Homo sapiens
88 LHFPL5  
Two-hybrid Homo sapiens
89 C17orf62 79415
Two-hybrid Homo sapiens
90 MFF 56947
Two-hybrid Homo sapiens
91 TPRG1  
Two-hybrid Homo sapiens
92 SCAMP5  
Two-hybrid Homo sapiens
93 TMEM71  
Two-hybrid Homo sapiens
94 CDIPT 10423
Two-hybrid Homo sapiens
95 SERF1A  
Two-hybrid Homo sapiens
96 ATXN1 6310
Two-hybrid Homo sapiens
97 TMEM14C 51522
Two-hybrid Homo sapiens
98 CDS2 8760
Two-hybrid Homo sapiens
99 NINJ2  
Two-hybrid Homo sapiens
100 PKMYT1  
Two-hybrid Homo sapiens
101 RNF24  
Two-hybrid Homo sapiens
102 CNGA4  
Affinity Capture-MS Homo sapiens
103 SLC30A2  
Affinity Capture-MS Homo sapiens
104 NCLN 56926
Affinity Capture-MS Homo sapiens
105 NDUFV3 4731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 VAPB 9217
Two-hybrid Homo sapiens
107 TMEM203  
Two-hybrid Homo sapiens
108 CANX 821
Affinity Capture-MS Homo sapiens
109 HSD11B1 3290
Affinity Capture-MS Homo sapiens
110 YIPF6 286451
Two-hybrid Homo sapiens
111 RTP2  
Two-hybrid Homo sapiens
112 CXorf66  
Two-hybrid Homo sapiens
113 COMMD8 54951
Two-hybrid Homo sapiens
114 THSD7B  
Two-hybrid Homo sapiens
115 HMOX2 3163
Two-hybrid Homo sapiens
116 PTH2R  
Affinity Capture-MS Homo sapiens
117 TVP23B  
Two-hybrid Homo sapiens
118 IL22RA1 58985
Affinity Capture-MS Homo sapiens
119 TMEM128  
Two-hybrid Homo sapiens
120 HSD3B7 80270
Proximity Label-MS Homo sapiens
121 CCL2 6347
Two-hybrid Homo sapiens
122 BNIP2  
Two-hybrid Homo sapiens
123 SRSF5 6430
Co-fractionation Homo sapiens
124 MTNR1A  
Two-hybrid Homo sapiens
125 NRM 11270
Two-hybrid Homo sapiens
126 FAM105A  
Two-hybrid Homo sapiens
127 HSD17B13  
Two-hybrid Homo sapiens
128 IER3  
Two-hybrid Homo sapiens
129 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
130 WFDC2  
Two-hybrid Homo sapiens
131 TCIRG1 10312
Affinity Capture-MS Homo sapiens
132 TMEM86B  
Two-hybrid Homo sapiens
133 SERP2  
Two-hybrid Homo sapiens
134 FAXDC2  
Two-hybrid Homo sapiens
135 BDKRB1 623
Two-hybrid Homo sapiens
136 CHRNA9  
Affinity Capture-MS Homo sapiens
137 RFT1 91869
Two-hybrid Homo sapiens
138 RABAC1 10567
Two-hybrid Homo sapiens
139 RPA3 6119
Proximity Label-MS Homo sapiens
140 ATP2A1 487
Proximity Label-MS Homo sapiens
141 ABCC1 4363
Co-fractionation Homo sapiens
142 ASPH 444
Two-hybrid Homo sapiens
143 SERF1B  
Two-hybrid Homo sapiens
144 NDUFA7 4701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 CTXN3  
Two-hybrid Homo sapiens
146 PLP2 5355
Two-hybrid Homo sapiens
147 NDUFA3  
Two-hybrid Homo sapiens
148 BNIP3 664
Two-hybrid Homo sapiens
149 FAM177A1 283635
Two-hybrid Homo sapiens
150 KCNK16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 MALL  
Two-hybrid Homo sapiens
152 SLC22A18 5002
Two-hybrid Homo sapiens
153 TMX2 51075
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
154 TMEM31  
Two-hybrid Homo sapiens
155 STX12 23673
Two-hybrid Homo sapiens
156 SFT2D1 113402
Two-hybrid Homo sapiens
157 TMEM239  
Two-hybrid Homo sapiens
158 TMEM51 55092
Two-hybrid Homo sapiens
159 CMTM7  
Two-hybrid Homo sapiens
160 PEX16 9409
Two-hybrid Homo sapiens
161 KCNA2  
Affinity Capture-MS Homo sapiens
162 MIP  
Two-hybrid Homo sapiens
163 ASGR1 432
Two-hybrid Homo sapiens
164 TMEM208  
Two-hybrid Homo sapiens
165 SMCO4  
Two-hybrid Homo sapiens
166 ATP1A3 478
Affinity Capture-MS Homo sapiens
167 PEX19 5824
Affinity Capture-MS Homo sapiens
168 ASIC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 SLC39A8 64116
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 TMEM120B  
Two-hybrid Homo sapiens
171 VAMP4 8674
Two-hybrid Homo sapiens
172 MS4A1 931
Two-hybrid Homo sapiens
173 PNLIPRP1  
Two-hybrid Homo sapiens
174 TLR5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 NSDHL 50814
Two-hybrid Homo sapiens
176 BTN2A2  
Two-hybrid Homo sapiens
177 REEP2  
Two-hybrid Homo sapiens
178 AGPAT3 56894
Two-hybrid Homo sapiens
179 TMEM121  
Two-hybrid Homo sapiens
180 SFXN1 94081
Two-hybrid Homo sapiens
181 HACD2 201562
Two-hybrid Homo sapiens
182 BRICD5  
Two-hybrid Homo sapiens
183 CGRRF1  
Affinity Capture-MS Homo sapiens
184 STX3 6809
Two-hybrid Homo sapiens
185 ZNRF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 YIPF2 78992
Two-hybrid Homo sapiens
187 CNGA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
188 VAMP5 10791
Two-hybrid Homo sapiens
189 IER3IP1 51124
Two-hybrid Homo sapiens
190 HNRNPU 3192
Co-fractionation Homo sapiens
191 NAT8  
Two-hybrid Homo sapiens
192 PTAFR  
Two-hybrid Homo sapiens
193 CCDC47 57003
Affinity Capture-MS Homo sapiens
194 PRAF2 11230
Two-hybrid Homo sapiens
195 CCDC167  
Two-hybrid Homo sapiens
196 MGST3 4259
Two-hybrid Homo sapiens
197 TRAM1L1  
Two-hybrid Homo sapiens
198 CXCL16 58191
Two-hybrid Homo sapiens
199 DERL1 79139
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TMX2 is involved
No pathways found





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