Gene description for TMX2
Gene name thioredoxin-related transmembrane protein 2
Gene symbol TMX2
Other names/aliases CGI-31
PDIA12
PIG26
TXNDC14
Species Homo sapiens
 Database cross references - TMX2
ExoCarta ExoCarta_51075
Entrez Gene 51075
HGNC 30739
UniProt Q9Y320  
 TMX2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for TMX2
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    biological_process GO:0008150 ND
    cell redox homeostasis GO:0045454 IEA
Subcellular Localization
    cellular_component GO:0005575 ND
    integral component of membrane GO:0016021 IEA
    cell GO:0005623 IEA
 Experiment description of studies that identified TMX2 in exosomes
1
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for TMX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TMX2 is involved
No pathways found





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