Gene description for SLC4A8
Gene name solute carrier family 4, sodium bicarbonate cotransporter, member 8
Gene symbol SLC4A8
Other names/aliases NBC3
NDCBE
Species Homo sapiens
 Database cross references - SLC4A8
ExoCarta ExoCarta_9498
Entrez Gene 9498
HGNC 11034
MIM 605024
UniProt Q2Y0W8  
 SLC4A8 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SLC4A8
Molecular Function
    sodium:bicarbonate symporter activity GO:0008510 IBA
    inorganic anion exchanger activity GO:0005452 IEA
Biological Process
    transmembrane transport GO:0055085 TAS
    ion transport GO:0006811 TAS
    regulation of intracellular pH GO:0051453 IBA
    anion transmembrane transport GO:0098656 IBA
    bicarbonate transport GO:0015701 TAS
    sodium ion transmembrane transport GO:0035725 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    neuronal cell body membrane GO:0032809 IEA
    neuron projection GO:0043005 IEA
    integral component of plasma membrane GO:0005887 IBA
 Experiment description of studies that identified SLC4A8 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SLC4A8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CA2 760
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 SLC9A3R1 9368
Reconstituted Complex Homo sapiens
3 CFTR  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which SLC4A8 is involved
PathwayEvidenceSource
Bicarbonate transporters TAS Reactome





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