Gene description for FYN
Gene name	FYN proto-oncogene, Src family tyrosine kinase
Gene symbol	FYN
Other names/aliases	SLK SYN p59-FYN
Species	Homo sapiens
Database cross references - FYN
ExoCarta	ExoCarta_2534
Entrez Gene	2534
HGNC	4037
MIM	137025
UniProt	P06241
FYN identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Neuroblastoma cells	25944692
Platelets	25332113
Platelets	25332113
Platelets	25332113
Prostate cancer cells	25844599
Thymus	23844026
Urine	22418980
Urine	22418980

Gene ontology annotations for FYN

Molecular Function     growth factor receptor binding GO:0070851 IPI     ephrin receptor binding GO:0046875 IPI     peptide hormone receptor binding GO:0051428 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ion channel binding GO:0044325 IEA     CD4 receptor binding GO:0042609 IEA     tubulin binding GO:0015631 IEA     glycoprotein binding GO:0001948 IPI     phosphatidylinositol 3-kinase binding GO:0043548 IEA     G-protein coupled receptor binding GO:0001664 IEA     CD8 receptor binding GO:0042610 IEA     non-membrane spanning protein tyrosine kinase activity GO:0004715 NAS     metal ion binding GO:0046872 IEA     T cell receptor binding GO:0042608 IEA     protein tyrosine kinase activity GO:0004713 TAS Biological Process     cellular response to platelet-derived growth factor stimulus GO:0036120 IEA     response to ethanol GO:0045471 IEA     cell migration GO:0016477 IBA     positive regulation of protein localization to nucleus GO:1900182 IEA     T cell costimulation GO:0031295 TAS     calcium ion transport GO:0006816 NAS     intracellular signal transduction GO:0035556 TAS     forebrain development GO:0030900 IEA     detection of mechanical stimulus involved in sensory perception of pain GO:0050966 IEA     protein phosphorylation GO:0006468 NAS     viral process GO:0016032 TAS     regulation of cell proliferation GO:0042127 IBA     response to drug GO:0042493 IEA     regulation of cell shape GO:0008360 IEA     positive regulation of neuron projection development GO:0010976 IEA     T cell activation GO:0042110 IBA     neuron migration GO:0001764 IEA     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     cell differentiation GO:0030154 IBA     platelet activation GO:0030168 TAS     blood coagulation GO:0007596 TAS     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     negative regulation of gene expression GO:0010629 IEA     negative regulation of neuron apoptotic process GO:0043524 IEA     cellular response to peptide hormone stimulus GO:0071375 IBA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     learning GO:0007612 TAS     activated T cell proliferation GO:0050798 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     negative regulation of protein catabolic process GO:0042177 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IMP     phosphatidylinositol-mediated signaling GO:0048015 TAS     leukocyte migration GO:0050900 TAS     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA     innate immune response GO:0045087 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     feeding behavior GO:0007631 TAS     dendrite morphogenesis GO:0048813 IEA     regulation of defense response to virus by virus GO:0050690 TAS     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     ephrin receptor signaling pathway GO:0048013 TAS     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IEA     regulation of apoptotic process GO:0042981 IBA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     axon guidance GO:0007411 TAS     T cell receptor signaling pathway GO:0050852 IDA Subcellular Localization     actin filament GO:0005884 IEA     nucleus GO:0005634 IEA     plasma membrane GO:0005886 IDA     postsynaptic density GO:0014069 IEA     cytosol GO:0005829 TAS     membrane raft GO:0045121 IDA     mitochondrion GO:0005739 IEA     endosome GO:0005768 IDA     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA