Gene description for CD2
Gene name CD2 molecule
Gene symbol CD2
Other names/aliases LFA-2
SRBC
T11
Species Homo sapiens
 Database cross references - CD2
ExoCarta ExoCarta_914
Vesiclepedia VP_914
Entrez Gene 914
HGNC 1639
MIM 186990
UniProt P06729  
 CD2 identified in exosomes derived from the following tissue/cell type
T cells 11907077    
Thymus 23844026    
 Gene ontology annotations for CD2
Molecular Function
    receptor activity GO:0004872 NAS
    protein homodimerization activity GO:0042803 IEA
    receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
Biological Process
    blood coagulation GO:0007596 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    positive regulation of interferon-gamma secretion GO:1902715 IDA
    heterotypic cell-cell adhesion GO:0034113 IDA
    leukocyte migration GO:0050900 TAS
    natural killer cell activation GO:0030101 NAS
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    regulation of T cell differentiation GO:0045580 NAS
    apoptotic process GO:0006915 TAS
    single organismal cell-cell adhesion GO:0016337 NAS
    membrane raft polarization GO:0001766 TAS
    positive regulation of myeloid dendritic cell activation GO:0030887 NAS
    positive regulation of interleukin-8 secretion GO:2000484 IMP
    T cell activation GO:0042110 TAS
Subcellular Localization
    external side of plasma membrane GO:0009897 IDA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IDA
    integral component of plasma membrane GO:0005887 NAS
    extracellular region GO:0005576 IEA
    cell-cell junction GO:0005911 IEA
    cytoplasmic side of plasma membrane GO:0009898 IEA
    anchored component of plasma membrane GO:0046658 IEA
 Experiment description of studies that identified CD2 in exosomes
1
Experiment ID 18
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method FACS
PubMed ID 11907077    
Organism Homo sapiens
Experiment description TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex.
Authors Blanchard N, Lankar D, Faure F, Regnault A, Dumont C, Raposo G, Hivroz C
Journal name JIMMU
Publication year 2002
Sample T cells
Sample name Jurkat
T cell blasts
Isolation/purification methods Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study FACS
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD2BP2 10421
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 CD247 919
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 CD4 920
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
4 CD48 962
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
5 PSTPIP1 9051
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
6 CD2AP 23607
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
7 CD58 965
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
8 LCK 3932
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
9 CD53 963
Invivo Homo sapiens
10 CD5 921
Affinity Capture-Western Homo sapiens
11 LGALS1 3956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
12 MXD1  
Invitro Homo sapiens
Invivo Homo sapiens
13 FYN 2534
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
14 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
15 PTPRC 5788
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
16 CD59 966
Affinity Capture-MS Homo sapiens
17 ITK 3702
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CD2 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome





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