Gene description for ITK
Gene name IL2-inducible T-cell kinase
Gene symbol ITK
Other names/aliases EMT
LPFS1
LYK
PSCTK2
Species Homo sapiens
 Database cross references - ITK
ExoCarta ExoCarta_3702
Entrez Gene 3702
HGNC 6171
MIM 186973
UniProt Q08881  
 ITK identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ITK
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    receptor binding GO:0005102 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
Biological Process
    regulation of cell proliferation GO:0042127 IBA
    cytokine production GO:0001816 ISS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    adaptive immune response GO:0002250 ISS
    innate immune response GO:0045087 TAS
    activation of phospholipase C activity GO:0007202 ISS
    T cell receptor signaling pathway GO:0050852 TAS
    interleukin-4 production GO:0032633 IEA
    signal transduction GO:0007165 TAS
    interferon-gamma production GO:0032609 IEA
    cellular defense response GO:0006968 TAS
    T cell activation GO:0042110 TAS
    NK T cell differentiation GO:0001865 IBA
    intracellular signal transduction GO:0035556 IEA
    peptidyl-tyrosine autophosphorylation GO:0038083 IBA
    B cell receptor signaling pathway GO:0050853 IBA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
Subcellular Localization
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA
    cell-cell junction GO:0005911 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ITK in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPK 3190
Invitro Homo sapiens
2 CD2 914
Affinity Capture-Western Homo sapiens
3 CBL 867
Invivo Homo sapiens
Invitro Homo sapiens
4 SRC 6714
Reconstituted Complex Homo sapiens
5 LAT 27040
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
6 BLNK  
Invitro Homo sapiens
7 FYN 2534
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
8 WAS 7454
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
9 SOCS1  
Reconstituted Complex Homo sapiens
10 PLCG1 5335
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 PPIA 5478
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
12 KPNA2 3838
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 GRB2 2885
Reconstituted Complex Homo sapiens
14 LCP2 3937
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
15 KHDRBS1 10657
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which ITK is involved
PathwayEvidenceSource
FCERI mediated Ca+2 mobilization TAS Reactome
Generation of second messenger molecules TAS Reactome





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